41st week of 2019 patent applcation highlights part 32 |
Patent application number | Title | Published |
20190310168 | AIRBORNE AGENT COLLECTORS, METHODS, SYSTEMS AND DEVICES FOR MONITORING AIRBORNE AGENTS - Air flow systems, devices and methods for monitoring airborne agents include airborne agent collectors. Airborne agent collectors for collecting and detecting the presence and/or identification of an airborne agent(s) include a soluble and hydrophilic polycaprolactone (PCL) that has been treated with a base (e.g., a base having a pH greater than 8 (e.g., NaOH, NaHCO | 2019-10-10 |
20190310169 | SYSTEM AND METHOD FOR SAMPLE PROCESSING - A method and system are described for processing tissues according to particular processing protocols that are established based on time-of-flight measurements as a processing fluid is diffused into a tissue sample. In one embodiment, measurement of the time it takes about 70% ethanol to diffuse into a tissue sample is used to predict the time it will take to diffuse other processing fluids into the same or similar tissue samples. Advantageously, the disclosed method and system can reduce overall processing times and help ensure that only samples that require similar processing conditions are batched together. | 2019-10-10 |
20190310170 | ACCELERATED WRIGHT-GIEMSA AND MAY-GRUNWALD STAINING METHODS - The present disclosure provides methods for carrying out Romanowsky-type stains, specifically Wright-Giemsa and May-Grünwald stains, quickly and efficiently. The methods greatly reduce the overall amount of time required to complete a Wright-Giemsa stain or a May-Grünwald stain of sufficient quality on a biological sample. The subject methods can be applied to both manual and automated staining procedures. | 2019-10-10 |
20190310171 | SEMICONDUCTOR MANUFACTURED NANO-STRUCTURES FOR MICROBE OR VIRUS TRAPPING OR DESTRUCTION - A device for isolating a microbe or a virion includes a semiconductor substrate; and a trench formed in the semiconductor substrate and extending from a surface of the semiconductor substrate to a region within the semiconductor substrate; wherein the trench has dimensions such that the microbe or the virion is trapped within the trench. | 2019-10-10 |
20190310172 | PROFILING EXTRACELLULAR VESICLES - Methods and compositions are provided for enriching extracellular vesicles, e.g., from bodily fluids. The vesicles may be indicative of various diseases. Vesicle characterization can be used for diagnostic, theranostic and other purposes. | 2019-10-10 |
20190310173 | BOND TEST APPARATUS AND METHOD - A bond test apparatus includes a test tool, a stage for mounting a bond for testing, and a drive mechanism comprising a voice coil. The voice coil is coupled to either the stage or to the test tool and is configured to provide relative movement between the stage and the test tool such that the bond applies a test force to the test tool. The bond test apparatus can also include a velocity sensor configured to sense an instantaneous relative velocity between the stage and the test tool, and a controller configured to control the drive mechanism in response to a signal from the velocity sensor. The bond test apparatus can also include a retarding mechanism coupled to the stage or the test tool and configured to apply, in response to relative movement between the stage and the test tool, a retarding force opposing the driving force. | 2019-10-10 |
20190310174 | FATIGUE LIMIT STRESS SPECIFICATION SYSTEM, FATIGUE LIMIT STRESS SPECIFICATION DEVICE, AND FATIGUE LIMIT STRESS SPECIFICATION METHOD - A fatigue limit stress specification system includes: a vibration generator that repeatedly applies a load to an object to be measured; a temperature sensor that measures a change in temperature of the object to be measured; and an information processing device that measures a fatigue limit stress of the object to be measured. The information processing device obtains a relation between a temperature amplitude of a fundamental frequency component of vibration for the object to be measured and a temperature amplitude of a second harmonic component of the vibration, performs fitting on the relation by using a first approximate line and a second approximate line, the first approximate line including a quadratic curve, the second approximate line including a quadratic curve, and obtains the fatigue limit stress of the object to be measured based on an intersection of the first approximate line and the second approximate line. | 2019-10-10 |
20190310175 | Rubber Wear Resistance Evaluation Method - Provided is a rubber wear resistance evaluation method including compressing and bonding a test sample of rubber with additional force to a circular circumferential surface of a rotation body rotated by a drive motor at a predetermined fixed position, holding the test sample in a state where movement of the test sample in a direction opposite to the addition force is always allowed, performing a wear test in which the test sample is worn, and using, at the time of evaluating wear resistance, an index based on at least one item out of two items including power required for driving and rotating the drive motor and a temperature of the test sample during the wear test, in addition to an amount of wear of the test sample. | 2019-10-10 |
20190310176 | Method for Predicting the Rubber Reinforcing Effect of Organic-Inorganic Composite for Rubber Reinforcement - The present disclosure relates to a method for predicting a rubber reinforcing effect of an organic-inorganic composite for rubber reinforcement. According to the present disclosure, a method for reliably predicting a rubber reinforcing effect of an organic-inorganic composite for rubber reinforcement by thermogravimetric analysis without mixing with a rubber composition is provided. | 2019-10-10 |
20190310177 | Isolation Device with Built-In Particle Counter - The present invention accurately manages the number of fine particles in a workspace and prevents fine particles from mixing with an experimental material. An isolation device for supplying a workspace with clean air resulting from dust filtration by an air cleaning means, said isolation device being provided with: a measurement probe that is for air intake and is disposed in the workspace; a particle counter for measuring the fine-particle counts for a plurality of particle sizes in the workspace air taken in by the measurement probe and outputting the measurements; a storage unit for storing, for each of the plurality of particle sizes and for work times and non-work times, management fine-particle counts at which the number of fine particles per unit volume is determined to be large; a cleanliness determination unit for determining cleanliness by comparing the fine particle counts for the plurality of particle sizes measured by the particle counter and the management fine-particle counts for the plurality of particle sizes stored by the storage unit; and an output unit for outputting an alarm if the cleanliness determination unit determines that the work-time/non-work time fine particle count for a particle size in the workspace during operation exceeds the corresponding management fine-particle count. | 2019-10-10 |
20190310178 | Measuring System and Manufacturing Process of Such a Measuring System - The invention relates to a system ( | 2019-10-10 |
20190310179 | MICROBIAL PARTICLE COUNTING SYSTEM AND MICROBIAL PARTICLE COUNTING METHOD - A microbial particle is accurately counted in distinction from a non-microbial particle. A preceding-stage irradiation section | 2019-10-10 |
20190310180 | BEAM SHAPING OPTICS OF FLOW CYTOMETER SYSTEMS AND METHODS RELATED THERETO - In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided. | 2019-10-10 |
20190310181 | DEVICE FOR MEASURING ADHESIVE POWER - A method and device for determining tensile force and adhesive force during the unwinding of a film from a roll without affecting the film, and which are usable at any radius of the spool and at any unwinding speed. The method and the device are based on determining the point where the film releases from the spool, and make use of the reflection of an ultrasonic wave. Emitted and reflected waves are radial at least when the emitted wave is incident upon the film which has not released from the spool. The method and device find applicability where tensile force, caused by the resistance of the roll to rotation, and also by adhesion of the film to the roll, must be determined. The method and device also find applicability where the adhesive force of the film to the roll must be determined. | 2019-10-10 |
20190310182 | Optical Flow Cell - The invention relates to an optical flow cell comprising a housing forming an enclosed and elongated fluid channel arranged along a first axis, an inlet arranged to connect a first outer surface area of the housing to a first end of the fluid channel and an outlet arranged to connect a second outer surface area to a second end of the fluid channel, a first light guide and a second light guide concentrically arranged along a second axis and on opposite side walls of the fluid channel. The invention further relates to a corresponding method to produce an optical flow cell. | 2019-10-10 |
20190310183 | OPTICAL SENSOR DEVICE AND PACKAGE INCLUDING THE SAME - Provided are an optical sensor device using surface acoustic waves and an optical sensor device package. The optical sensor device includes: a substrate including a first light sensing area and a temperature sensing area and including a piezo electric material; a first input electrode and a first output electrode which are disposed in the first light sensing area and are apart from each other with a first delay gap therebetween; a first sensing film overlapping the first delay gap and configured to cover at least some portions of the first input electrode and the first output electrode; and a second input electrode and a second output electrode which are disposed in the temperature sensing area and are apart from each other with a second delay gap therebetween. The second delay gap is exposed to air. | 2019-10-10 |
20190310184 | SIGNAL PROCESSING APPARATUS, SIGNAL PROCESSING METHOD, AND PROGRESS - A signal processing apparatus, method, and program that enable growth conditions of vegetation to be easily confirmed are disclosed. An NDVI relative value calculation provides a relative value to an average of a vegetation index indicative of growth conditions of grass, on the basis of a sensing image. An image indicative of the growth conditions of an inspection object can be displayed on the basis of the relative value. Further, an NDVI average calculation section calculates an NDVI average obtained by averaging normalized difference vegetation indexes NDVI indicative of the growth conditions of the grass in the entire grass, and a correlation coefficient calculation section calculates a correlation coefficient that matches the NDVI average with a predetermined NDVI specified value. The NDVI relative value calculation applies the correlation coefficient in providing the relative value in each measurement unit in which a measurement is performed on the grass. | 2019-10-10 |
20190310185 | METHOD FOR DETERMINING THE CONCENTRATION OF A SUBSTANCE IN A DEFORMABLE CONTAINER - The invention relates to a non-destructive and non-invasive method for determining the concentration or other parameters of constituent substances in fluids, which method is capable of minimizing the optical interfering influences, which are unknown but constant during the individual measurement, of the vessel wall on the measurement result or the evaluation, in that measurements are carried out with different through-radiation path lengths and quotient calculations eliminate the influences of the vessel wall. Wide-area illumination and detection ensure that non-linearities occurring during said measurements do not interfere with the accuracies of the determination. | 2019-10-10 |
20190310186 | GAS SENSOR - The present invention relates to a gas sensor employing a non-dispersive infrared (NDIR) scheme. The gas sensor may comprise: a light source portion for emitting light; a light cavity portion for multi-reflecting the emitted light; a light detecting portion for detecting the multi-reflected light; a first light coupling portion for reflecting and concentrating the light emitted by the light source portion toward the light cavity portion; and a second light coupling portion for reflecting and concentrating the light reflected by the light cavity portion toward the light detecting portion. The first light coupling portion may comprise a light emitting surface that faces a side surface of the light cavity portion and has a via hole through which light passes, and a reflecting surface extending from the light emitting surface so as to surround the upper portion and the side portion of the light source portion such that light emitted by the light source portion is reflected toward the via hole of the light emitting surface. The second light coupling portion may comprise a light incident surface that faces a side surface of the light cavity portion and has a via hole through which light incident from the light cavity portion passes, and a reflecting surface extending from the light incident surface so as to surround the upper portion and the side portion of the light detecting portion such that light incident from the light cavity portion is reflected toward the light detecting portion. | 2019-10-10 |
20190310187 | SKIN CANCER BIOMARKER DETECTION BY INFRARED SPECTROSCOPY - The present invention relates to a method for detection in IR (infrared) spectra of human epidermal skin tissue the presence of the multiplet around 1055 cm | 2019-10-10 |
20190310188 | GAS ANALYSIS DEVICE - A gas analysis device includes a light source configured to emit laser beam to a target gas, a reflection body which reflects the laser beam, a light reception device that receives the laser beam reflected by the reflection body, a container which contains the light source and the light reception device, and an alignment mechanism that includes an insertion member inserted from outside of the container to inside of the container to move, along a plane intersecting with the irradiation direction of the laser beam, at least any one of the light source and the light reception device. | 2019-10-10 |
20190310189 | APPARATUS AND METHOD FOR DETERMINING A REFRACTIVE INDEX - An apparatus ( | 2019-10-10 |
20190310190 | Inspection Apparatus Having Non-Linear Optics - An inspection apparatus or lithographic apparatus includes an optical system and a detector. The optical system includes a non-linear prismatic optic. The optical system is configured to receive zeroth and first diffraction order beams reflected from a diffraction target and separate first and second polarizations of each diffraction order beam. The detector is configured to simultaneously detect first and second polarizations of each of the zeroth and first diffraction order beams. Based on the detected first and second polarizations of one or more diffraction orders, an operational parameter of a lithographic apparatus can be adjusted to improve accuracy or precision in the lithographic apparatus. The optical system can include a plurality of non-linear prismatic optics. For example, the optical system can include a plurality of Wollaston prisms. | 2019-10-10 |
20190310191 | Device And Method For Detecting The Presence of Determined Molecules, And Biosensor - The invention relates to a device ( | 2019-10-10 |
20190310192 | Equilibrium Plasmonic Mercury Sensing Apparatus and Methods - Apparatus and methods are provided for quantitative detection of mercury vapor in gas samples using a film of nanoparticles. The localized surface plasmon resonance (LSPR) of an amalgam nanoparticle is sensitive to adsorbed mercury mass. The equilibrium mass of mercury on a gold nanoparticle is a function of the surrounding vapor concentration and the temperature of the gold. A device that introduces a temperature-controlled gold nanoparticle film to a controlled flow of sample gas responds predictably to a given mercury vapor concentration when optically probed in situ. Controlling the temperature of the film allows for control of adsorption and desorption rates. Equilibrium plasmonic mercury detection, described herein, removes the cycling necessary for many gold-based mercury analyses. Methods are given for the operation and analysis of the temperature-stabilized gold nanoparticle mercury sensor. The disclosed mercury-detection apparatus and methods find use in a variety of applications, including, for example, mercury detecting applications. | 2019-10-10 |
20190310193 | UV-VIS SPECTROSCOPY INSTRUMENT AND METHODS FOR COLOR APPEARANCE AND DIFFERENCE MEASUREMENT - Embodiments of the invention generally relate to color and appearance metric measurements and, in particular, developing instrumentation to enable self-consistent image appearance measurements within instruments of unitary construction. | 2019-10-10 |
20190310194 | IN-LINE COATING WEIGHT AND RADIANT ENERGY EXPOSURE MEASUREMENT - A method for measuring the radiant exposure of energy curable inks or coatings on a printing press. The steps for measuring comprise: a) providing an ink or coating material comprising a fluorescent probe; b) transferring the ink or coating material onto a substrate using a printing process; c) exposing the ink or coating material to actinic radiation capable of initiating cure of the ink or coating material that also alters the luminescence of the probe; d) exposing the ink or coating to a first source of excitation light with wavelength and luminance capable of absorption by the fluorescent probe; and e) measuring the emitted light from the fluorescent probe by a first detector. | 2019-10-10 |
20190310195 | FINGERMARK LIFTING AND VISUALIZATION DEVICE AND METHODS OF USE THEREOF - A fingermark lifting and visualization device includes a carrier and an indicator. The carrier has a lifting surface. The indicator is immobilized on the lifting surface. The indicator changes color or changes in fluorescence in the visible spectrum in response to contact with a glandular secretion. | 2019-10-10 |
20190310196 | DETECTION OF FLUORESCENCE OF FOREIGN MATERIALS - A method of detecting a presence of foreign material in a ply is disclosed. A source of foreign material is marked with a fluorescent indicator. The source of foreign material is separated from the ply. An illumination source is provided for illuminating the ply at a different wavelength than the fluorescent indicator fluoresces so that the ply reflects light at a different wavelength. A sensor detects illumination of the ply and fluorescent indicator included in the foreign material disposed upon the ply. Differences in light reflected from the ply and fluorescence of the indicator disposed in the foreign material are detected thereby identifying existence of the foreign material in the ply. | 2019-10-10 |
20190310197 | CELL COUNTER - Cell counters and methods of their use are disclosed herein. The cell counters comprise a sample mounting system that includes a base comprising a mounted lower sample surface and a cover comprising a mounted upper sample surface; a bright-field light source incorporated in the cover; an objective lens mounted below the sample mounting system; optionally, a fluorescence excitation source in optical communication with the sample mounting system; and an imaging system in optical communication with the bright-field light source and the objective lens. The mounted sample surfaces are configured for repeated use, such that disposable sample cartridges are not needed. | 2019-10-10 |
20190310198 | FLUORESCENCE LIFETIME MEASUREMENT APPARATUS AND METHOD CAPABLE OF FINDING TWO OR MORE FLUORESCENCE LIFETIME COMPONENTS BY COMPUTING LEAST SQUARE ERROR THROUGH VIRTUAL FLUORESCENCE DISTRIBUTION MODEL FROM SIGNAL COLLECTED IN ANALOG MEAN DELAY METHOD - A fluorescence lifetime measurement apparatus according to an embodiment of the present invention includes an illumination light generation unit configured to generate illumination light, a fluorescence photon detection unit configured to collect a fluorescence signal of fluorescence photons generated by illuminating at least one or more samples including fluorescent molecules with the illumination light; and a measurement unit configured to compute a fluorescence lifetime by applying a least square method to a simulation function and a function of the fluorescence signal. | 2019-10-10 |
20190310199 | Systems and Methods for 4-D Hyperspectral Imaging - Systems and methods for hyperspectral imaging are described. In one implementation, a hyperspectral imaging system includes a sample holder configured to hold a sample, an illumination system, and a detection system. The illumination system includes a light source configured to emit excitation light having one or more wavelengths and a diffractive element. The illumination system is configured to structure the excitation light into a predetermined two-dimensional pattern at a conjugate plane of a focal plane in the sample, spectrally disperse the structured excitation light in a first lateral direction, and illuminate the sample in an excitation pattern with the one or more wavelengths dispersed in the first lateral direction. | 2019-10-10 |
20190310200 | Surface-Enhanced Raman Scattering Substrate, Element for Detecting Molecule Including the Same, and Method for Manufacturing the Same - A surface-enhanced Raman scattering substrate includes a floating-type first metal nanoparticle; a support body for supporting the first metal nanoparticle; and a second metal film which forms a nano gap with the first metal nanoparticle and is surrounding the circumference of the first metal nanoparticle, wherein a first metal of the first metal nanoparticle and a second metal of the second metal film, respectively, can be a metal generating surface plasmons thereon. | 2019-10-10 |
20190310201 | PORTABLE LASER INDUCED BREAKDOWN SPECTROSCOPY SYSTEMS - An embodiment of a laser induced breakdown system is described that comprises a portable device that includes: a laser configured to produce a beam comprising a plurality of repeating pulses; a processor configured to open a data acquisition window after a delay period, wherein the delay period begins upon production of one of the pulses; one or more optical elements configured to direct the beam at a sample and collect emitted light from a plasma continuum; and an optical detector configured to produce a plurality of signal values from the emitted light from the plasma continuum collected during the data acquisition window, wherein the processor is configured to identify an element from the signal values. | 2019-10-10 |
20190310202 | Real-Time Silica Discriminating Respirable Aerosol Monitor - An airborne silica detection system provides a chemiluminescence reaction for quantitative assessment of silica on an automated basis. A prefilter allows reaction to be sensitive to particle sizes relevant to chronic respiratory diseases. | 2019-10-10 |
20190310203 | QUANTIFYING COLOR CHANGES OF CHEMICAL TEST PADS INDUCED BY SPECIFIC CONCENTRATIONS OF BIOLOGICAL ANALYTES UNDER DIFFERENT LIGHTING CONDITIONS - Color quantification of chemical test pads and titration of analytes can be performed under different lighting conditions. In one embodiment, the lighting condition is estimated under which a digital image is captured and utilized to select a set of reference colors from which the quantified color is compared to determine the titration. In another embodiment, a plurality of comparisons are made with different lighting conditions with the result having the highest confidence level being selected to determine the titration. | 2019-10-10 |
20190310204 | DIRECTED ENERGY AND SENSING FOR DETECTION OF INCONSISTENCIES IN LAMINATES - A method for detecting inconsistencies in an assembly using an energy source and an imaging device is disclosed. An energy source directs energy through first scanning mirrors toward a surface of the laminated composite assembly raising an energy level of an inspection area. An imaging device directs a view through second scanning mirrors toward the inspection area and the imaging device detects a rate of change in energy at the surface of the laminated composite. Movement of the first scanning mirrors is synchronized with movement of the second scanning mirrors for directing a view of the imaging device to the inspection area after the energy level of the area of the surface has been raised. The imaging device detects dissipation of energy at the area of the surface being inspected and identifies inconsistencies associated defects in the assembly. | 2019-10-10 |
20190310205 | MEASUREMENT CYCLE DETERMINATION DEVICE, MEASUREMENT CYCLE DETERMINATION PROGRAM AND METHOD THEREOF - To suitably determine a measurement cycle at which to measure cracks that occur in structures formed from concrete or the like. Resolution Means: A measurement cycle determination device ( | 2019-10-10 |
20190310206 | DUST DETECTION APPARATUS AND METHOD OF MANUFACTURING THE SAME - Provided are a dust detection apparatus a method of manufacturing the same, and the dust detection apparatus may include a body capable of sucking in or discharging air containing dust, by using a fan, and including a fluidic channel through which the sucked air flows, a light emitter provided in the body to radiate a light signal by using a laser device, a lens provided in the body to concentrate the light signal radiated from the laser device, a light receiver provided in the body to detect scattered light generated when the radiated light signal is scattered by the dust in the air, a substrate provided in the body to mount electronic components thereon, and a shield case surrounding the body to be at least partially in contact with the substrate. | 2019-10-10 |
20190310207 | RAMAN SPECTROSCOPY AND MACHINE LEARNING FOR QUALITY CONTROL - This disclosure relates to methods for determining the quality of polymers, more particularly, polyolefins. The methods involve Raman spectroscopy and artificial intelligence to compute polymer properties and/or features. | 2019-10-10 |
20190310208 | X-ray Tensor Tomography System - The present invention relates to an X-ray tensor tomography (XTT) system ( | 2019-10-10 |
20190310209 | SPECIMEN HOLDER - In at least one embodiment, a specimen holder includes a specimen holder shaft unit having a specimen and/or specimen mesh setting unit, an outer tubular unit capable of housing the specimen holder shaft unit, a thermal drift adjusting unit made of a material having a different thermal expansion coefficient from a thermal expansion coefficient of the specimen holder shaft unit and partially in contact with the specimen holder shaft unit, and a control mechanism which controls movement of the thermal drift adjusting unit toward a center direction of a specimen. | 2019-10-10 |
20190310210 | An NMR multi-dimensional method for measuring coupling constants within several coupling networks - This invention provides a NMR multi-dimensional method for measuring coupling constants within several coupling networks. At first, a 90° hard pulse was performed to flip the magnetization from the Z axis to the XY plane. After t | 2019-10-10 |
20190310211 | SYSTEM AND METHOD FOR MAGNETIC RESONANCE MAPPING OF PHYSICAL AND CHEMICAL CHANGES IN CONDUCTING STRUCTURES - A method of diagnosing a conducting structure includes providing the conducting structure in a magnetic field, immersing the conducting structure in a detection medium, or placing a detection medium in the vicinity of the conducting structure, exciting nuclear or electronic spins within the detection medium using a broad-band excitation pulse, receiving an NMR or ESR spectrum from the detection medium, obtaining a frequency distribution of the detection medium, and indirectly measuring internal characteristics of the conducting structure by characterizing frequency changes in the frequency distribution. Conducting structures are analyzed on the basis of changes in magnetic susceptibilities and internal electric current distributions, which may change over the course of a charging/discharging cycle, and a result of degradation and failure of the conducting structure. The conducting structure may be, for example, a battery, a capacitor, a supercapacitor, a fuel cell, or a catalyst material. | 2019-10-10 |
20190310212 | THERMAL HUMIDITY MEASURING DEVICE - It is an object of the present invention to provide a thermal humidity measuring device that has a configuration including a first heating element and a second heating element and that is capable of obtaining a plurality of measurement values (measured values) including humidity measured by the first heating element, by effectively utilizing each of the heating elements. | 2019-10-10 |
20190310213 | DEW POINT MEASURING METHOD AND DEW POINT MEASURING DEVICE - The purpose of the present invention is to realize a dew point measurement in which the generation of dew condensation is directly detected and the detection can be performed without using any optical system. In particular, the purpose of the present invention is to realize a dew point measuring device that is compact and has a high sensitivity. According to one embodiment of the present invention, a sudden change in current values before and after the dew point is detected by detecting the dew condensation to detect a galvanic current that flows due to a water droplet attached onto a surface of an insulating substrate on which thin wires of dissimilar metals are juxtaposed, and by controlling the temperature on the surface of the substrate. In this way, the dew point measurement in which the dew point can be directly measured and a measurement with simple configuration and high accuracy can be performed can be realized. | 2019-10-10 |
20190310214 | DEVICES, SYSTEMS AND METHODS TO DETECT THE PRESENCE OF -LACTAM ANTIBIOTIC HYDROLYZING BACTERIA IN A SAMPLE - Various devices, systems and methods for detecting the presence of β-lactam antibiotic hydrolyzing bacteria in a sample are disclosed. In one embodiment, a method of detecting the presence of β-lactam antibiotic hydrolyzing bacteria includes introducing the sample to a filter configured to capture bacteria in the sample; introducing a buffer solution to the bacteria captured on the filter surface, wherein the buffer solution comprises a β-lactamase substrate, a β-lactamase activator, and a lysing agent to lyse cells of the bacteria to release β-lactam antibiotic hydrolyzing enzymes; exposing a sensor having an electrical characteristic to a reaction mixture comprising the buffer solution and the β-lactam antibiotic hydrolyzing enzymes; and monitoring a change in the electrical characteristic of the sensor to detect the presence of the β-lactam antibiotic hydrolyzing bacteria in the sample originally introduced. | 2019-10-10 |
20190310215 | ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY ANALYZER ("EISA") CHIP FOR A MICROELECTROMECHANICAL SYSTEM (MEMS) - Various embodiments may provide an electrochemical impedance spectroscopy analyzer (EISA) chip for a microelectromechanical system (MEMS). In various embodiments, the EISA chip may perform an electrochemical impedance spectroscopy (EIS) test on a battery and may gather sensor data associated with a battery from sensors on the MEMS. | 2019-10-10 |
20190310216 | GAS SENSOR WITH A CONFIGURABLE HEATING ELEMENT, AND METHODS EXPLOITING THE CONFIGURABILITY - In a gas sensor having a gas-sensitive layer and a heating element to heat the gas-sensitive layer, the heating element comprises a heater track having first and second outer electric terminals and at least one inner electric terminal located between the outer electric terminals. The gas sensor includes a control unit configured to control the electric potentials that are applied to the electric terminals during use, and the control unit is configured to be capable of varying the set of electric potentials applied to the electric terminals. In certain applications the control unit may select the terminals to which power is applied, in order to assure the gas-sensitive layer is heated to a specified temperature. In certain applications the gas sensor has multiple measurement electrodes and the control unit selects the set of electric potentials so that different temperatures are attained at locations where different measurement electrodes are located. | 2019-10-10 |
20190310217 | MULTI-DIMENSIONAL APPROACH TO IMAGING, MONITORING, OR MEASURING SYSTEMS AND PROCESSES UTILIZING CAPACITANCE SENSORS - A system and method for imaging, monitoring, or measuring systems and processes utilizing only data provided from capacitance sensors. The present invention combines the multi-frequency method of both ECVT/AECVT and DCPT to image or measure processes and systems more efficiently and accurately than the methods alone. The present system analyzes capacitance and current phase acquired at multiple frequencies to determine a plurality of properties of single and multiphase systems all at once. The combined use of ECVT and DCPT in multiphase flow can also be extended to measure volume fraction and phase distribution of flows involving greater than three phases by using multiple frequencies for capacitance, current phase, or both. | 2019-10-10 |
20190310218 | ENHANCED SENSOR FOR A CONTINUOUS BIOLOGICAL MONITOR - Briefly, a sensor for a continuous biological monitor is provided for measuring the level of a target analyte for a patient. The sensor has a working wire and a reference wire, where the working wire has an analyte limiting layer that passes more than 1 in 1000 analyte molecules from the patient to the an enzyme layer . The enzyme layer has an enzyme entrapped in a polyurethane cross-linked with acrylic polyol. As free electrons are generated, a conductor transfers the electrons to the biological monitor. In some cases, the sensor may be constructed without the use of any expensive platinum. | 2019-10-10 |
20190310219 | ENHANCED INTERFERENCE MEMBRANE FOR A WORKING ELECTRODE OF A CONTINUOUS BIOLOGICAL SENSOR - Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with a new interfere layer that is (1) non-electron conducting, (2) ion passing, and (3) permselective for molecular weight. The new interference layer is made by mixing a monomer and a mildly basic buffer, and then electropolymerizing the monomer and the buffer into a polymer. The polymer is deposited onto a working electrode for a continuous metabolic monitor, for example, using an electro depositing process in the form of cyclic voltammety (CV). The interference layer is permselectable for molecule size by adjusting the pH of the basic buffer. | 2019-10-10 |
20190310220 | ENHANCED ENZYME MEMBRANE FOR A WORKING ELECTRODE OF A CONTINUOUS BIOLOGICAL SENSOR - Briefly, a sensor for a continuous biological monitor is provided that has a working electrode with an enhanced enzyme layer that in one embodiment is made by mixing an aqueous polyurethane emulsion with an acrylic polyol emulsion to make a base emulsion. An enzyme is added to the base emulsion, which is applied to the working electrode and cured. Optionally, other additives can be added to the base emulsion prior to application, such as hydrophiles, cross linkers, adding imodeoesters, hydroxysuccimide, carboldilite, melamines, epoxies, benzoyl peroxide or dicumyl peroxide. | 2019-10-10 |
20190310221 | METHOD AND DEVICE FOR DETERMINING A CONCENTRATION OF AT LEAST ONE ANALYTE - A method for determining a concentration of at least one analyte in bodily fluid, comprising: a signal generation step, wherein an excitation voltage signal is generated by a signal generator, wherein the excitation voltage signal comprises a poly frequent alternating current (AC) voltage and a direct current (DC) voltage profile, wherein the poly frequent AC voltage comprises at least two frequencies; a signal application step, wherein the excitation voltage signal is applied to at least two measurement electrodes; a measurement step, wherein a response is measured by using the measurement electrodes; an evaluation step, wherein an AC current response for each frequency and a DC current response are evaluated from the response; a determination step, wherein the concentration of the analyte is determined from the DC current response and from one or both of the phase and impedance information by using at least one predetermined relationship. | 2019-10-10 |
20190310222 | CARBON WORKING ELECTRODE FOR A CONTINUOUS BIOLOGICAL SENSOR - Briefly, a carbon working electrode is described that has a plastic substrate of polyethylene, polypropylene, polystyrene, polyvinyl chloride, or polylactic acid, and may be formed into an elongated wire. The carbon material coats the plastic substrate, and may be, for example, graphene, diamagnetic graphite, pyrolytic graphite, pyrolytic carbon, carbon black, carbon paste, or carbon ink, which is aqueously dispersed in an elastomeric material such as polyurethane, silicone, acrylates or acrylics. Optionally, selected additives may be added to the carbon compound prior to it being layered onto the plastic substrate. These additives may, for example, improve electrical conductivity or sensitivity, or act as a catalyst for target analyte molecules. | 2019-10-10 |
20190310223 | CARBON NANOFIBER SENSOR FOR NON-ENZYMATIC GLUCOSE DETECTION AND METHODS OF GLUCOSE DETECTION USING SUCH CARBON NANOFIBER SENSOR - A general methodology for the development of sensitive and selective sensors that can achieve a low cost detection of glucose without using enzymes is disclosed. The method uses carbon nanofiber (CNF) array electrodes for the electrochemical detection of glucose. CNFs grown by plasma enhanced chemical vapor deposition (PECVD) with diameters ranging from 13-160 nm and a height of approximately one micrometer are preferred. The CNFs have a sensitivity of 2.7 μA/mM cm | 2019-10-10 |
20190310224 | SENSOR ELEMENT FOR A POTENTIOMETRIC SENSOR - The present disclosure relates to a sensor element for a potentiometric sensor including a substrate, and a potentiometric sensor layer disposed on the substrate, wherein the substrate includes at least one region electrically conductively connected to the sensor layer, and wherein at least the region of the substrate electrically conductively connected to the sensor layer is a mixed-conducting ceramic. | 2019-10-10 |
20190310225 | MICROFLUIDIC ORGANIC ELECTROCHEMICAL TRANSISTOR SENSORS FOR REAL TIME NITRIC OXIDE DETECTION - The present disclosure describes a solution to rapidly detect trace amounts of biomarkers present in a fluid sample. The solution can be, for example, used to diagnosis sepsis through the detection of nitric oxide. The solution includes one or more organic electrochemical transistors that are functionalized with a bio-recognition coating. The bio-recognition coating can bind or otherwise interact with the biomarkers to change the transconductance of the organic electrochemical transistors. The solution can detect the change in the transconductance of the organic electrochemical transistors and signal the presence of the biomarker. | 2019-10-10 |
20190310226 | ELECTROPHORESIS FLOW CHANNEL CLEANING METHOD AND ELECTROPHORESIS DEVICE - A polymer not including a fluorescent dye is introduced into an electrophoresis flow channel and electrophoresis is performed (Steps S | 2019-10-10 |
20190310227 | DEVICE AND METHOD FOR ISOTACHOPHORETIC FOCUSING LARGE SAMPLE VOLUMES - The present invention provides, in some embodiments, an isotachophoresis (ITP) apparatus, a kit comprising same and method of use thereof for the focusing analytes of interest from large sample volumes. | 2019-10-10 |
20190310228 | METHODS OF CHARACTERIZING ION-EXCHANGED CHEMICALLY STRENGTHENED GLASSES CONTAINING LITHIUM - Methods of characterizing ion-exchanged chemically strengthened glass containing lithium are disclosed. The methods allow for performing quality control of the stress profile in chemically strengthened Li-containing glasses having a surface stress spike produced in a potassium-containing salt, especially in a salt having both potassium and sodium. The method allows the measurement of the surface compression and the depth of the spike, and its contribution to the center tension, as well as the compression at the bottom of the spike, and the total center tension and calculation of the stress at the knee where the spike and the deep region of the stress profile intersect. The measurements are for a commercially important profile that is near-parabolic in shape in most of the interior of the substrate apart from the spike. | 2019-10-10 |
20190310229 | GAS SENSOR AND GAS DETECTION METHOD - A gas sensor includes: at least one resonator; a vibrator provided on the at least one resonator; at least one converter that converts sound waves outputted from the at least one resonator to an electric signal; and a detection unit that detects a specific gas on the basis of the electric signal attained by conversion by the at least one converter, wherein the vibrator includes at least either one of: a plurality of vibrating bodies that have respectively differing frequency characteristics during vibration, that vibrate a gas inside the at least one resonator, and that output sound waves by resonance of the at least one resonator; and a heater that heats a gas inside the at least one resonator, and that outputs sound waves by resonance of the at least one resonator. | 2019-10-10 |
20190310230 | Acoustic Frequency Based System with Crystalline Transducer Module for Non-invasive Detection of Explosives, Contraband, and other Elements - The present invention relates to a system and method for molecular and/or atomic level detection of elements forming contraband such as concealed explosives, drugs, smuggled goods, etc., through the use of an acoustic frequency detector having a crystalline transducer module and elemental and mass comparator. The present invention can be employed in a non-destructive manner for the mobile and stationary inspection of objects such as luggage, persons, containers, etc., through a combination of computer-aided techniques and algorithms combined with a crystalline and oil enhanced transducer that, upon return of a system-generated acoustic signal, are used to screen and confirm explosive threats and/or other contraband. | 2019-10-10 |
20190310231 | CMUT PROBE, SYSTEM AND METHOD - Disclosed is an ultrasound probe ( | 2019-10-10 |
20190310232 | DIAGNOSIS DEVICE - A diagnosis device includes a data acquirer, a data recorder, and a health diagnoser. The data acquirer acquires a measurement data of a structure at a predetermined timing. The data recorder causes a storage to store the measurement data acquired by the data acquirer as a standard data. The health diagnoser diagnoses a health of the structure by comparing the measurement data that is acquired by the data acquirer this time with the standard data that has been acquired by the data acquirer last time and stored in the storage. | 2019-10-10 |
20190310233 | LC-Column with Dynamic-Axial Compression (DAC) - A separating column for use with a filling tube to prepare for chromatography is disclosed. The separating column includes an axially movable spring stamp; and a plurality of springs coupled to the stamp. Moreover, the stamp is depressed directly into the column tube during column packing via the filling tube. Additionally, the stamp is fixed in the column tube while maintaining the packing pressure so that the springs are compressed during the packing process and press the stamp permanently and dynamically onto a chromatographic bed. | 2019-10-10 |
20190310234 | ELUCIDATION OF ION EXCHANGE CHROMATOGRAPHY INPUT OPTIMIZATION - The present invention provides methods for determining chromatography separation conditions; for example, separation of a polypeptide and its charge variants. The invention also provides methods to determine a buffer condition for chromatography separation conditions. The invention also provides a robust method to analyze multiple polypeptide products. | 2019-10-10 |
20190310235 | METHODS FOR COLORIMETRIC ENDPOINT DETECTION AND MULTIPLE ANALYTE TITRATION SYSTEMS - Systems for quantifying one or more target analyte concentrations in a process solution are provided and can be used, for example, in methods for quantifying a target analyte concentration. These systems and methods include continuous and batchwise automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution using a multiwavelength detector. The methods provide for efficient and robust automated titration methods for a variety of target analytes and can include methods that analyze more than one analyte and that provide for a dynamic range for measurement of more than one target analyte concentration. | 2019-10-10 |
20190310236 | SUBMERSIBLE MULTI-PARAMETER SONDE HAVING A HIGH SENSOR FORM FACTOR SENSOR - Provided are multi-parameter sonde systems having a unique form-factor, wherein the plurality of sensors are arranged in a tight-fit configuration. This provides a single distal sensing surface and minimal separation distance between adjacent sensors. The sensors may be pie shaped with an interlocking feature to tightly hold the sensors together, with a sensor guard disposed over the outer surface of the interlocked sensors. Sensor-guards disclosed herein may have an integrated sensor storage and sensor guard configuration, thereby avoiding a need for a separate storage cup and that are configured to minimize unwanted biological growth. Also provided are uniquely shaped individual sensors having interlocking features to hold several sensors together in a sonde. | 2019-10-10 |
20190310237 | METHOD FOR PREDICTION OF LIVE OIL INTERFACIAL TENSION AT RESERVOIR CONDITIONS FROM DEAD OIL MEASUREMENTS - In an embodiment a method is described which includes emplacing a sample within a measurement cell, wherein two or more electrodes are configured in the measurement cell; introducing a reactive fluid into the measurement cell; reacting the sample with the reactive fluid, wherein reacting the sample with the reactive fluid results in a change in an ion concentration in the reactive fluid; and measuring the resistivity of the reactive fluid using the two or more electrodes, wherein the resistivity is proportional to the ion concentration in the reactive fluid. | 2019-10-10 |
20190310238 | SOIL ANALYZING DEVICE AND SOIL ANALYZING METHOD - A soil analyzing device includes: a sensor having an excitation coil and a detection coil; a measurement unit that generates an excitation signal to be input to the excitation coil, and processes a detection signal output from the detection coil; a storage unit that stores data concerning the correlation between a quantitative value of the soil fertility characteristics including CEC of two or more types of the soil having different components and an estimated value of the soil fertility characteristics including CEC found from the processed detection signal measured by the sensor and the measurement unit; and an estimation unit that estimates the soil fertility characteristics based on the detection signal generated by allowing the sensor to apply the alternating magnetic field to the soil to be analyzed and processed by the measurement unit, and by using the data stored in the storage unit. | 2019-10-10 |
20190310239 | SYSTEMS AND METHODS FOR MEASURING WATER AND LIPID CONTENT IN TISSUE SAMPLES - An imaging system for measuring water and blood lipid content in a tissue sample includes a light source configured to emit a plurality of sequential wavelengths of light within a predetermined range of wavelengths, a spatial modulation device configured to direct each of the plurality of sequential wavelengths of light onto a tissue sample plane to generate a first plurality of patterns on the issue sample plane at a first spatial frequency and a second plurality of patterns on the tissue sample plane at a second spatial frequency, an imaging device configured to generate first image data reproducible as images the first plurality of patterns and second image data reproducible as images the second plurality of patterns, and a controller configured to determine a first optical property and a second optical property for each location on the sample plane. | 2019-10-10 |
20190310240 | NANO-GAP ELECTRODE PAIR AND METHOD OF MANUFACTURING SAME - A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap. | 2019-10-10 |
20190310241 | FABRICATION OF TUNNELING JUNCTIONS WITH NANOPORES FOR MOLECULAR RECOGNITION - Embodiments of the present technology may allow for improved and more reliable tunneling junctions and methods of fabricating the tunneling junctions. Electrical shorting issues may be reduced by depositing electrodes without a sharp sidewall and corner but instead with a sloping or curved sidewall. Layers deposited on top of the electrode layer may then be able to adequately cover the underlying electrode layer and therefore reduce or prevent shorting. Additionally, two insulating materials may be used as the dielectric layer may reduce the possibility of incomplete coverage and the possibility of flaking. Furthermore, the electrodes may be tapered from the contact area to the junction area to provide a thin electrode where the hole is to be patterned, while the thicker contact area reduces sheet resistance. The electrode may also be patterned to be wider at the contact area and narrower at the junction area. | 2019-10-10 |
20190310242 | ANALYSIS OF A POLYMER COMPRISING POLYMER UNITS - A sequence of polymer units in a polymer ( | 2019-10-10 |
20190310243 | METHODS AND COMPOSITIONS FOR DETERMINING THE PRESENCE OR ABSENCE OF DNA ABERRATIONS - The invention consists of methods and compositions for detecting the presence or absence of a DNA aberration by analyzing fluorescence emission characteristics in sperm cells or sperm nuclei, which generally consists of entraining sperm cells or sperm nuclei stained with a DNA selective dye in sheath fluid; exposing the entrained sperm cells or sperm nuclei to electromagnetic radiation; determining a forward fluorescence characteristic and a side fluorescence characteristic of individual events associated with the exposed sperm cells or sperm nuclei; and gating the individual events based on the forward fluorescence characteristic and the side fluorescence characteristic with a criterion. | 2019-10-10 |
20190310244 | OLIGONUCLEOTIDES FOR INDUCING PATERNAL UBE3A EXPRESSION - The present invention relates to oligonucleotides that are capable of inducing expression of ubiquitin-protein ligase E3A (UBE3A) from the paternal allele in animal or human neurons. The oligonucleotides target the suppressor of the UBE3A paternal allele by hybridization to SNHG14 long non-coding RNA downstream of SNORD109B. The present invention further relates to pharmaceutical compositions and methods for treatment of Angelman syndrome. | 2019-10-10 |
20190310245 | System and Method for Identifying and Quantifying Species with Nanopores, using Complexes of Nanoparticles with Carrier Particles - A multiplexed digital detection platform embodiment for molecular species in solution is based on a single-molecule immunochemistry, and/or aptamer chemistry, on color-barcoded beads. Beads that capture molecular species from a complex sample using selective binders are exposed to a test sample, and the captured molecular species is tagged using second affinity probes that are linked to photocleavable nucleic acid particles. In the embodiment, the beads are then introduced to a counter system that comprises a microcavity/nanopore device. Once a bead is captured by the micropore, nucleic acid particles, e.g., reporter nucleic acid nanoparticles (rNANPs), are released using photocleavage, and are detected by the nanopore. Each electrical spike that is uniquely produced by the nucleic acid nanoparticle is counted as a single molecular species, and the total count represents the overall number of molecular species in the sample. Various molecular species can be detected at the same time. | 2019-10-10 |
20190310246 | ROTORS FOR IMMUNOASSAYS - The present invention provides an analyte detection system for detecting target analytes in a sample. In particular, the invention provides a detection system in a rotor or disc format that utilizes a centrifugal force to move the sample through the detection system. Methods of using the rotor detection system to detect analytes in samples, particularly biological samples, and kits comprising the rotor detection system are also disclosed. | 2019-10-10 |
20190310247 | FLUID TEST CARTRIDGE, FLUID TEST APPARATUS INCLUDING THE SAME, AND METHOD FOR CONTROLLING THE FLUID TEST APPARATUS - A fluid test cartridge, a fluid test apparatus, and a method for controlling the same. The fluid test apparatus includes a housing, and a fluid test cartridge that is accommodated in the housing. The fluid test cartridge includes at least one chamber in which a fluid sample to be tested and a drying reagent can be accommodated. The fluid test apparatus includes a light emitter configured to emit light to the at least one chamber, a light sensor, and a processor configured to detect a concentration of a first material in the fluid sample. The drying reagent includes a non-metallic particle bound to a second material that specifically binds to the first material. Tests can thus be carried out over a wider range of wavelengths, and testing errors can be reduced. | 2019-10-10 |
20190310248 | METHOD FOR REMOVING MICROORGANISM, CELL, TINY VESICLE SECRETED BY SAID MICROORGANISM OR SAID CELL OR VIRUS FROM CARRIER-IMMOBILIZED ANTIBODY - The present invention provides a method for removing a microorganism, a cell, a vesicle secreted by the microorganism or the cell, or a virus from an antibody immobilized on a carrier and to which the microorganism or the like has been bound as an antigen. The present invention also provides an immunological detection method of the microorganism or the like, including removing the microorganism or the like from an antibody immobilized on a carrier and to which the microorganism or the like has been bound as an antigen. | 2019-10-10 |
20190310249 | Antigens Derived from Citrullinated 14-3-3 and Uses Thereof in the Diagnosis of Rheumatoid Arthritis - The present invention provides citrullinated 14-3-3η peptides and antibodies thereto and methods of using same to evaluate arthritic conditions such as rheumatoid arthritis. | 2019-10-10 |
20190310250 | METHODS FOR THE USE OF GALECTIN 3 BINDING PROTEIN DETECTED IN THE URINE FOR MONITORING THE SEVERITY AND PROGRESSION OF LUPUS NEPHRITIS - Embodiments of the present invention describe compositions and methods incorporating the measurement of LGALS3BP in the urine of patients diagnosed with lupus nephritis (LN) in order to monitor the severity and progression of said LN. | 2019-10-10 |
20190310251 | SYSTEM AND PRODUCTS FOR IMPROVED QUANTIFICATION OF ADCC ACTIVITY - The activity of a number of therapeutic antibodies is mediated in part by antibody-dependent cell-mediated cytotoxicity (ADCC). An engineered effector cell line expressing the low affinity Fc receptor, FcγR111a (CD16), that responds to ligation of the Fc moiety of antibody bound to the specific antigen expressed on target cells by activation of a NFAT responsive reporter gene is described. In this cell line the firefly luciferase (FL) reporter gene is regulated by a novel synthetic chimeric promoter containing binding sites for NF-AT, AP1, NFkB, and STAT5 that confers improved sensitivity, an improved dynamic range, an improved tolerance to human serum and a reduced incubation time, relative to engineered effector cell lines that express a NFAT regulated reporter-gene, when used in an ADCC assay together with engineered target cells. The target cells have been engineered to over-express a constant high level of the specific antigen recognized by the therapeutic antibody, and homologous control cells have been developed in which the gene encoding the specific drug target has been invalidated by genomic editing. Target cells that have been engineered to over-express a constant level of CD20 together with homologous control cell line, in which the gene encoding CD20 has been invalidated, have been used to quantify the ADCC activity of Rituxan with a high degree of precision and with minimal interference from human serum. | 2019-10-10 |
20190310252 | Selection and optimization of aptamers to recognize ebola markers - Aptamers have been identified that bind to the sGP protein in ebola virus. The aptamers are single stranded DNA aptamers. The aptamers have high specificity and bind sGP in serum samples. The aptamers can be used to detect infection of individuals with ebola virus. Methods for detecting ebola virus in an individual are disclosed. | 2019-10-10 |
20190310253 | METHOD FOR DIAGNOSING COMPLICATED PARAPNEUMONIC EFFUSION - A method for diagnosing complicated parapneumonic effusion is revealed. A sandwich enzyme-linked immunosorbent assay (ELISA) is used to measure a level of a target protein in a pleural effusion. Then the level is compared with a preset baseline corresponding to the target protein so as to determine whether the pleural effusion is a complicated parapneumonic effusion (CPPE). The target protein can be further used in combination with conventional CPPE biomarkers to improve sensitivity and specificity in clinical diagnosis of CPPE. | 2019-10-10 |
20190310254 | A NOVEL METABOLIC DISORDER TARGET - Methods are disclosed herein for identifying a compound of use in treating a condition treatable by metformin. The methods include determining if the test compound binds a subunit of the mitochondrial electron transport complex IV, and/or alters the function of the mitochondrial electron transport complex IV. Methods for treating a subject with a condition treatable by metformin, are also disclosed. In some embodiments, the condition is type II diabetes. | 2019-10-10 |
20190310255 | PROTEINS - The present invention relates to the identification of membrane proteins associated with B-cell non-Hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia and chronic lymphocytic leukaemia), melanoma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer and retinoblastoma which have utility as markers and for treatment of said cancers and which also form biological targets against which antibodies such as therapeutic antibodies (or other affinity reagents) or other pharmaceutical agents can be made. | 2019-10-10 |
20190310256 | DISCOVERY AND VALIDATION OF CANCER BIOMARKERS USING A PROTEIN ANALYSIS METHODOLOGY TO ANALYZE SPECIMENS - Methods are provided for the analysis, including the serial analysis, of very small samples of tissue. The methods utilize a nanofluidic proteomic immunoassay (NIA) to quantify total and low-abundance protein isoforms in a small amount of lysate. NIA detection accurately measure oncoprotein expression and activation in limited clinical specimens, including isoforms that differ in post-translational modifications, such as phosphorylation, and the like. The NIA detection method combines isoelectric protein focusing and antibody detection in a nanofluidic system. | 2019-10-10 |
20190310257 | METHOD FOR DISCRIMINATING BETWEEN PROSTATE CANCER AND A BENIGN PROSTATE DISEASE - A method of analyzing diagnostic information for estimating which of a benign prostate disease and prostate cancer is affecting a subject to be diagnosed combines two methods of analyzing diagnostic information. The first method includes measuring a concentration of a mucin-1 (Tn-MUC1), reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine->serine(threonine) residue, in a subject blood sample, comparing the measured value with a threshold value, and estimating that a disease affecting the subject is benign prostate disease when the measured value is greater than the threshold value. The second method includes measuring a concentration of a prostate-specific antigen (LacdiNAc-PSA), reactive with a lectin that recognizes and binds to an N-acetyl-D-galactosamine B1-4 N-acetylglucosamine residue in the blood sample, comparing the measured value with a threshold value, and estimating that the disease affecting the subject is prostate cancer when the measured value of LacdiNAc-PSA is greater than the threshold value. | 2019-10-10 |
20190310258 | BIOMARKER, METHOD FOR SEARCHING DISEASE-RELATED GENE, AND RENAL CANCER MARKER - Provided is a method wherein an affected tissue and a normal tissue obtained from the vicinity of the affected tissue are left at rest in a culture medium, and a disease-specific biomarker is searched for in an exudate therefrom. A biomarker specific to renal cell carcinoma has been found by this method. | 2019-10-10 |
20190310259 | ENIGMA AND CDH18 AS COMPANION DIAGNOSTICS FOR CDK4 INHIBITORS - The present invention relates to the use of one or more biomarkers to evaluate the likelihood that a CDK4 inhibitor would produce an anti-cancer effect in a subject. Accordingly, in certain non-limiting embodiments, the present invention provides for methods, compositions and kits for a companion diagnostic for CDK4 inhibitors, and in particular, for the use of the colocalization of Enigma and CDH18 biomarkers to foci within the cancer for determining whether the cancer can be successfully treated by CDK4 inhibition. | 2019-10-10 |
20190310260 | Regeneratable Biosensor and Methods of Use Thereof - A multiplex-able, regeneratable nucleic-acid linked immunoassay method and system for the detection of a single specific, or multiple, soluble analytes in solution and regeneratable biosensor devices for same are described. | 2019-10-10 |
20190310261 | NOVEL TARGET FOR ANTI-CANCER AND IMMUNE-ENHANCING - The present disclosure provides a pharmaceutical composition for treating or preventing cancer, comprising inhibitors of KIRREL3, CNTN4 and/or CD351. In addition, the present disclosure provides a pharmaceutical composition for immune-enhancing, comprising inhibitors of KIRREL3, CNTN4 and/or CD351. Furthermore, the present disclosure provides a method of screening of anti-cancer agent using KIRREL3, CNTN4 and/or CD351, and a method of providing information necessary for analysis of cancer prognosis using KIRREL3, CNTN4 and/or CD351. | 2019-10-10 |
20190310262 | ANALYTE DETECTION - This disclosure relates generally to detection and, in particular, to detecting objects within a sample or fraction thereof. | 2019-10-10 |
20190310263 | FLUORESCENT SENSORS OF PEROXYNITRITE TARGETED TO THE ENDOPLASMIC RETICULUM - A compound can be a pro-fluorophore peroxynitrite sensor that generates a fluorophore when cleaved by peroxynitrite, having a structure of Formula A: | 2019-10-10 |
20190310264 | TECHNIQUES FOR HIGH THROUGHPUT TARGETED PROTEOMIC ANALYSIS AND RELATED SYSTEMS AND METHODS - Described herein is a kit of materials prepared for assays that involve determining relative abundance and/or absolute abundance of various targeted peptides. The kit may comprise trigger versions of target peptides with masses offset from the respective target peptides by predetermined and known amounts. The trigger peptides may be present in amounts that may be readily detected via a mass spectrometry analysis. When mixed with samples that are analyzed, detection of the trigger peptides indicates where in the mass-spectrometer output the target peptide may be found. The kit may include a predetermined amount of synthetic versions of one or more of the target peptides. A measured relative abundance of this synthetic peptide relative to that of the target peptides yields an absolute quantitative value of the target peptide. Also disclosed is a method of preparing a plurality of samples to be submitted for mass spectrometer analysis in parallel. | 2019-10-10 |
20190310265 | CITRULLINATED BRAIN AND NEUROLOGICAL PROTEINS AS BIOMARKERS OF BRAIN INJURY OR NEURODEGENERATION - The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis. | 2019-10-10 |
20190310266 | USE OF BIOMARKERS FOR ASSESSING TREATMENT OF GASTROINTESTINAL INFLAMMATORY DISORDERS WITH BETA7 INTEGRIN ANTAGONISTS - The present invention is directed to methods of using biomarkers to assess treatment of gastrointestinal inflammatory disorders with beta7 antagonists. More particularly, the present invention relates to methods of using the level of gut-homing lymphocytes in peripheral blood, the level of drug occupancy on gut-homing lymphocytes, and/or the level of beta7 integrin receptors on gut-homing lymphocytes as indicators (or biomarkers) of the effect, efficacy, safety, prognosis, and/or dosing of therapeutic agents, such as beta7 integrin antagonists, for the treatment of gastrointestinal inflammatory disorders. | 2019-10-10 |
20190310267 | METHODS FOR DIAGNOSING MOTOR NEURON DISEASES - The invention relates to methods for determining whether a subject is afflicted with a motor neuron disease, the method comprising conducting an analysis of cerebrospinal fluid and/or plasma, measuring the level of one or more sterol/oxysterol analytes, and comparing these to reference values. Further, the invention relates to methods of identifying agents suitable for the treatment of MND, and monitoring the progress of the disease. | 2019-10-10 |