| 46th week of 2012 patent applcation highlights part 46 |
| Patent application number | Title | Published |
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| 20120289401 | METHOD FOR PRODUCING NANOPARTICLES - A method for producing nanoparticles includes: producing a nanoparticle dispersion ion gel in which a plurality of nanoparticles are dispersed; and dissolving the nanoparticle dispersion ion gel, thereby producing a liquid in which the plurality of nanoparticles are dispersed. | 2012-11-15 |
| 20120289402 | ADJUVANT COMPOSITION AND AGROCHEMICAL FORMULATION CONTAINING SAME - An adjuvant composition is provided which comprises:
| 2012-11-15 |
| 20120289403 | Fluorinated Oxa or Thia Heteroarylalkylsulfide Derivatives for Combating Invertebrate Pests - The invention relates to alkylsulfide derivatives compounds of formula I as hereunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R | 2012-11-15 |
| 20120289404 | Pesticidal Mixtures - The present invention relates to an agrochemical mixture for increasing the health of a plant, comprising as active ingredients a herbicidal compound (I) selected from the group consisting of: benzoic acids, pyridine carboxylic acids, quinoline carboxylic acids, and_benazolin-ethyl; and a fungicidal compound (II) in synergistically effective amounts. The present invention further relates to a method for improving the health of a plant, wherein the plant, the locus where the plant is growing or is expected to grow or plant propagation material from which the plant grows is treated with an effective amount of a mixture as defined above. In addition, the invention relates to the use of a mixture as defined above for synergistically increasing the health of a plant. | 2012-11-15 |
| 20120289405 | CONTACT ELEMENT INTENDED FOR A SUPERCONDUCTING CABLE UNIT - A contact element ( | 2012-11-15 |
| 20120289406 | SUPERCONDUCTING MAGNET SYSTEM FOR HIGH POWER MICROWAVE SOURCE FOCUSING AND CYCLOTRON ELECTRONIC APPARATUS - A superconducting magnet system for high power microwave source focusing and cyclotron electronic apparatus is provided, wherein, the superconducting magnet comprises an inner superconducting main coil, an outer superconducting main coil, two end compensation coils, a regulating coil and a central regulating coil. These coils are formed by coiling Nb | 2012-11-15 |
| 20120289407 | Superconducting System For Enhanced Natural Gas Production - Provided is a natural gas processing facility for the liquefaction or regasification of natural gas. The facility includes a primary processing unit, e.g., refrigeration unit, for warming natural gas or chilling natural gas to at least a temperature of liquefaction. The facility also has superconducting electrical components integrated into the facility. The superconducting electrical components incorporate superconducting material so as to improve electrical efficiency of the facility by at least one percent over what would be experienced through the use of conventional electrical components. The superconducting electrical components may be one or more motors, one or more generators, one or more transfonners, switch gears, one or more electrical transmission conductors, variable speed drives, or combinations thereof. | 2012-11-15 |
| 20120289408 | COMPOSITIONS AND METHODS FOR NUCLEIC ACID SEQUENCING - Compositions and methods for nucleic acid sequencing include template constructs that comprise double stranded portions in a partially or completely contiguous constructs, to provide for redundant sequence determination through one or both of sequencing sense and antisense strands, and iteratively sequencing the entire construct multiple times. Additional sequence components are also optionally included within such template constructs. Methods are also provided for the use and preparation of these constructs as well as sequencing compositions for their application. | 2012-11-15 |
| 20120289409 | Species Specific Nucleotide (SSN) Sequences as a Rapid Diagnostic - A data base of species specific nucleotide sequences (SSN) is created. The chemically synthesized sequences are used as DNA sequencing primers. Different mixes of DNA primers allow for the rapid and unique identification of any pathogen previously identified in the species specific data base. | 2012-11-15 |
| 20120289410 | GENETIC VARIANT IN FORMYL PEPTIDE RECEPTOR 2 (FPR2) PREDICTS CLINICAL OUTCOME IN CANCER PATIENTS - The disclosure provides compositions and methods for determining the likely tumor recurrence in cancer patients by screening formyl peptide receptor 2 (FPR2) polymorphism in samples isolated from the patient. | 2012-11-15 |
| 20120289411 | METHOD FOR SCREENING NUCLEIC ACID LIGAND - Provided is a method for screening a library of candidate for a nucleic acid ligand. The method includes the steps of: (a) preparing a library of candidate of nucleic acid ligands; (b) contacting, under the absence of a target substance, the library with a supporting member binding to at least one of conserved sequence domains included in the ligand, and then separating and removing a ligand which does not form an intermolecular duplex; and (c) dissociating the intermolecular duplex by contacting, under the presence of the target substance, the target substance with the remaining ligand forming the intermolecular duplex obtained in step (b), and then separating and collecting a ligand having a specific secondary structure formed by the binding to the target substance, wherein the method includes at least one time of step (b) and at least one time of step (c). | 2012-11-15 |
| 20120289412 | COMPLEXITY REDUCTION METHOD - The present invention relates to a method for the reduction of the complexity of nucleic acid pool(s), comprising
| 2012-11-15 |
| 20120289413 | METHODS FOR OPERATING AN ARRAY OF CHEMICALLY-SENSITIVE SENSORS - Methods and apparatus relating to very large scale FET arrays for analyte measurements. ChemFET (e.g., ISFET) arrays may be fabricated using conventional CMOS processing techniques based on improved FET pixel and array designs that increase measurement sensitivity and accuracy, and at the same time facilitate significantly small pixel sizes and dense arrays. Improved array control techniques provide for rapid data acquisition from large and dense arrays. Such arrays may be employed to detect a presence and/or concentration changes of various analyte types in a wide variety of chemical and/or biological processes. In one example, chemFET arrays facilitate DNA sequencing techniques based on monitoring changes in hydrogen ion concentration (pH), changes in other analyte concentration, and/or binding events associated with chemical processes relating to DNA synthesis. | 2012-11-15 |
| 20120289414 | METHOD FOR MULTIPLEXED NUCLEIC ACID PATCH POLYMERASE CHAIN REACTION - The invention encompasses a method for amplifying at least two different nucleic acid sequences. In particular, the method encompasses a multiplexed nucleic acid patch polymerase chain reaction. | 2012-11-15 |
| 20120289415 | METHODS AND PRODUCTS RELATED TO THE IMPROVED ANALYSIS OF CARBOHYDRATES - The invention relates, in part, to the improved analysis of carbohydrates. In particular, the invention relates to the analysis of carbohydrates, such as N-glycans and O-glycans found on proteins and saccharides attached to lipids. Improved methods, therefore, for the study of glycosylation patterns on cells, tissue and body fluids are also provided. Information from the analysis of glycans, such as the glycosylation patterns on cells, tissues and in body fluids, can be used in diagnostic and treatment methods as well as for facilitating the study of the effects of glycosylation/altered glycosylation. Such methods are also provided. Methods are further provided to assess production processes, to assess the purity of samples containing glycoconjugates, and to select glycoconjugates with the desired glycosylation. | 2012-11-15 |
| 20120289416 | METHODS AND KITS USED IN ASSESSING CANCER RISK - Methods of assessing the risk of recurrence of endometrial cancer on the basis of the presence or absence of mutations in FGFR2 are disclosed. | 2012-11-15 |
| 20120289417 | T Cell Epitope Databases - The invention relates to databases of T cell epitopes, especially helper T cell epitopes, for rapid interrogation of protein sequences for the presence of T cell epitopes. The invention includes full or partial databases and data structures of T cell epitopes including epitopes identified especially by ex vivo T cell assays with test peptides and includes T cell epitopes identified by extrapolation of data from test peptides. The present invention also includes high throughput methods for determining the T cell epitope activity of peptides for subsequent inclusion in databases and data structures including methods where subsets of T cell especially regulatory T cells are removed or inhibited from T cell assays in order to maximize the sensitivity of detection of T cell epitope activity. | 2012-11-15 |
| 20120289418 | DIAGNOSTIC METHOD AND KIT FOR THE DETECTION OF A LYMPHOCYTIC VARIANT OF HYPEREOSINOPHILIC SYNDROME - The present invention is related to a gene set, a kit and a method for diagnosis of lymphocytic variant hypereosinophilic syndrome. | 2012-11-15 |
| 20120289419 | Methods and Compositions for the Target-localized Anchoring of Detectable Label - Highly reactive functionalized substrates and linker molecules for use in the detection of molecular targets and other analytes of interest are provided as are kits, reaction mixtures and methods utilizing the same. | 2012-11-15 |
| 20120289420 | MICRORNA BIOMARKERS FOR AIRWAY DISEASES - The present invention provides miRNA biomarkers useful for diagnosis, prognosis, and/or treatment of airway diseases such as asthma, asthma exacerbation and nasal polyps. | 2012-11-15 |
| 20120289421 | Method and Apparatus for High Accuracy Genomic Analysis Platform Utilizing Hybridization and Enhanced Dissociation - Methods and an apparatus according to the present invention, can be used in capture/enrichment, gene expression profiling and targeted sequencing. Provided are methods for improving accuracy and stringency of microarrays and/or other genomic analysis methods relying on nucleic acid hybridization and melting curve analysis by controlling surface chemistry. This method comprises producing a positively charged surface or surface coating, on the surface of microarray slides or other types of surfaces similarly purposed, such as micro beads, which enhances melting curve analysis to the point of allowing detection or differentiation of small changes in sequences between nucleic acid binding partners. Also provided is an improved microarray reader machine, to collect melting curve data on microarray slides. The accuracy or resolution of melting curve analysis was to be sufficient to distinguish between the melting of perfect matched dsDNA and dsDNA with the smallest possible change in sequence, a one base pair mismatch. | 2012-11-15 |
| 20120289422 | QUANTITATIVE DIAGNOSTIC METHODS USING MULTIPLE PARAMETERS - Materials and Methods related to diagnosing a clinical condition in a subject, or determining the subject's predisposition to develop the clinical condition, using a multi-parameter system to measure a plurality of parameters and an algorithm to determine a disease score. | 2012-11-15 |
| 20120289423 | ONLINE REAL-TIME WATER QUALITY MONITORING AND CONTROL SYSTEM INCORPORATING SYSTEMS FOR AUTOMATED MICROBIOLOGICAL TESTING AND ONE-STEP DNA DETECTION - A system for detecting deoxyribonucleic acid (DNA) biomarkers. The system is configured to monitor and control standard parameters (temperature, pH, free chlorine, redox potential, TDS, turbidity), via an array of sensors. The system is configured to perform automated microbiological testing using a DNA hybridization based optical detection sensor, wherein the sensor is configured to provide automated sample collection, primer and buffer addition, thermocycling and fluorescence detection via laser excitation and a linear CCD. | 2012-11-15 |
| 20120289424 | IGF1R POLYMORPHISM PREDICTS TUMOR RECURRENCE IN BREAST CANCER PATIENTS - The disclosure provides compositions and methods for determining the likely tumor recurrence in breast cancer patients by screening IGFR1 polymorphism in samples isolated from the patient. | 2012-11-15 |
| 20120289425 | Techniques for Identifying, Confirming, Mapping and Categorizing Polymers - Systems and methods for identifying, confirming, mapping, and categorizing sample polymers, such as nucleic acid sequences, are provided. An estimation of the fraction of first and second polymers in a sample of polymers can be calculated by inputting a first hybridization value indicative of hybridization affinity of the sample of polymers to polymers probes that are complementary to the first polymer and inputting a second hybridization value indicative of hybridization affinity of the sample of polymers to polymers probes that are complementary to the second polymer. The estimation of the fraction of the first and second polymers in the sample of polymers can then be calculated by dividing the first hybridization value by a sum of the first and second hybridization values. Estimations of the fractions of alleles in a sample can be clustered to form a fraction pattern usable for identifying, confirming, mapping, and genotyping sample nucleic acids. | 2012-11-15 |
| 20120289426 | METHOD FOR AMPLIFICATION OF TARGET NUCLEIC ACID - A method for amplifying a target nucleic acid is disclosed, which includes: (a) fragmenting a nucleic acid sample to create a target fragment comprising a target nucleic acid and two probe-complementary portions; (b) contacting said fragmented nucleic acid sample with a probe comprising two target fragment-complementary portions complementary to the probe-complementary portions of the target fragment; (c) rendering the fragmented nucleic acid sample single-stranded; (d) allowing the probe-complementary portions to hybridise with the target-fragment complementary portions; (e) if the probe in step (b) is not immobilised, immobilising the probe-target fragment hybrid on a solid phase via immobilisation moiety; (f) separating non-immobilised nucleic acid fragments from the solid phase; (g) contacting the solid phase with a ligase to ligate ligatable 5′ and 3′ ends of the target fragment whereby the target fragment is circularized; and (h) amplifying said circularized target fragment. | 2012-11-15 |
| 20120289427 | DETECTION METHOD FOR MICROARRAY - Described is a means for objectively determining hybridization failure in addition to performance degradation, insufficient washing and the like in a microarray. In particular a method for detecting the hybridization between a probe polynucleotide and a target polynucleotide by using a microarray is presented. | 2012-11-15 |
| 20120289428 | ULTRA-SENSITIVE DETECTION OF MOLECULES OR PARTICLES USING BEADS OR OTHER CAPTURE OBJECTS - The present invention relates to systems and methods for detecting analyte molecules or particles in a fluid sample and in some cases, determining a measure of the concentration of the molecules or particles in the fluid sample. Methods of the present invention may comprise immobilizing a plurality of analyte molecules or particles with respect to a plurality of capture objects. At least a portion of the plurality of capture objects may be spatially separated into a plurality of locations. A measure of the concentration of analyte molecules in a fluid sample may be determined, at least in part, on the number of reaction vessels comprising an analyte molecule immobilized with respect to a capture object. In some cases, the assay may additionally comprise steps including binding ligands, precursor labeling agents, and/or enzymatic components. | 2012-11-15 |
| 20120289429 | BIOCHIP COMPRISING MULTIPLE MICROCHANNELS - A biochip includes a plurality of microchannels; and a plurality of probes disposed in an inner wall of each of the plurality of microchannels forming a one-dimensional array. The one-dimensional array of probes are configured to react with a sample in the microchannel. The plurality of microchannels are arranged such that the plurality of probes of the plurality of microchannels form a two-dimensional or three-dimensional array. | 2012-11-15 |
| 20120289430 | METHODS FOR MEASURING ENHANCEMENT IN THE QUALITY OF LIFE OF AN ANIMAL - A method to measure enhancement in the quality of life of an animal fed a super senior pet food composition comprising quantitating the gene expression levels of one or more genes in said animal and comparing said levels in the animal to levels in the animal prior to administration of said super senior pet food composition. A method to enhance the quality of life of an animal by modulating the expression level of one or more genes in said animal in order to mimic the pattern of expression seen in vivo after administration of a super senior pet food composition. | 2012-11-15 |
| 20120289431 | DIAGNOSIS OF BREAST CANCER BASED ON EXPRESSION LEVEL OF THIOREDOXIN-1 - The present disclosure relates to a diagnostic marker for breast cancer, having thioredoxin-1 as an active ingredient, and to a diagnostic kit for breast cancer using the same. The thioredoxin-1 is overexpressed in human breast cancer tissue so as to enable the early diagnosis of breast cancer or the early prediction prognosis of breast cancer, and therefore has a valuable use as a diagnostic marker for breast cancer. The present disclosure further relates to a method for the diagnosis of breast cancer comprising measuring serum thioredoxin 1 level. In addition, the method is useful in the early diagnosis of breast cancer thanks to its high diagnostic sensitivity and selectivity. | 2012-11-15 |
| 20120289432 | PI3K MODULATORS, RHO KINASE MODULATORS AND METHODS OF IDENTIFYING AND USING SAME - Disclosed are methods to characterize PI3K inhibitors and Rho kinase inhibitors using label-free cellular assays. Disclosed are also methods to characterize a cell whether it has a deregulated PI3K pathway or not. | 2012-11-15 |
| 20120289433 | SOLID SURFACE RESERVOIRS - An apparatus for forming a surface reservoir to hold a sample for a desirable period of time is described. The apparatus contains a platform, a solid surface disposed onto the platform, and an assembly of a bottomless vessel mounted on the solid surface. Also described is an apparatus that forms an array of surface reservoirs on a solid surface when multiple bottomless vessels are used, which can be used for high throughput applications. The apparatus can be used in applications on a solid surface, such as immunohistochemistry (IHC), oligo synthesis, peptide synthesis, ELISA, DNA array, peptide array, protein array, antibody array, tissue array, cell culturing, etc. | 2012-11-15 |
| 20120289434 | SYSTEMS AND METHODS FOR DEVELOPING DIAGNOSTIC TESTS BASED ON BIOMARKER INFORMATION FROM LEGACY CLINICAL SAMPLE SETS - Disclosed are systems and methods for developing diagnostic tests (e.g., detection, screening, monitoring, and prognostic tests) based on biomarker information from legacy clinical sample sets, for which only small sample volumes (e.g., about 0.05 to about 1.0 mL or less per sample) are typically available. For example, biomarkers (e.g., about 10, 50, 100, 150, 200, 300, or more) may be detected in the clinical samples through the use of single molecule detection and each biomarker may be detected in an assay that includes about 1 μL or less of a legacy clinical sample. | 2012-11-15 |
| 20120289435 | Drilling fluid additive with low freezing point - A drilling fluid additive, is provided, and the additive comprises: syrup solids and a liquid medium; and the sugar content of the additive is directly proportionate to the freezing point of the additive. | 2012-11-15 |
| 20120289436 | METHODS FOR CONTROLLING DEPOLYMERIZATION OF POLYMER COMPOSITIONS - A method of controlling or arresting the rate of depolymerization of a polymer composition during a biocide treatment, and use of such methods in oilfield and industrial applications. Also disclosed are methods of preparing a visco-stable application fluid containing a biocide in an amount effective to reduce bacteria count, as well as additive compositions capable of reducing bacteria count in application fluids while maintaining viscosity in such fluids. Also disclosed are methods of preparing biocide-containing application fluids with improved friction reducing properties, as well as related compositions. | 2012-11-15 |
| 20120289437 | NON-AQUEOUS DRILLING ADDITIVE USEFUL TO PRODUCE A FLAT TEMPERATURE-RHEOLOGY PROFILE - The present application, at least in part, is directed to a method of providing a substantially constant rheological profile of an oil-based drilling fluid over a temperature range of about 120° F. to about 40° F. In some embodiments, the method comprises adding a drilling fluid additive to the drilling fluid, wherein the drilling fluid additive consists essentially of a polyamide and a set of at least one or more mono-carboxyl units. The polyamide has (a) repeat units of (i) a poly-carboxyl unit with at least two carboxylic moieties; and (ii) a polyamine unit having an amine functionality of two or more and the one or more mono-carboxyl units being positioned on the polyamide at a position selected from the group consisting of: an end position, a pendant position and combinations thereof. | 2012-11-15 |
| 20120289438 | DRILLING FLUIDS COMPRISING HYDROXYLATED POLYMERS - Drilling fluids comprising polymers containing hydroxylated structural units are useful as accretion inhibiting agents, and/or as fluid rheology controlling agents, and/or as filtrate reducing agents, and/or as lubricating agents. | 2012-11-15 |
| 20120289439 | PROCESS FOR THE MANUFACTURE OF SULPHIDE COMPOUNDS - A process for the manufacture of carbon disulphide comprising the following steps reacting carbon dioxide with hydrogen sulphide to form carbonyl sulphide and water; and absorbing at least a portion of the water with a sorbent, leaving a mixture comprising carbonyl sulphide, carbon dioxide, and hydrogen sulphide. | 2012-11-15 |
| 20120289440 | METHODS, APPARATUS, AND SYSTEMS FOR INCORPORATING BIO-DERIVED MATERIALS INTO OIL SANDS PROCESSING - Methods, processes, apparatus, systems, and compositions are disclosed for improving the sustainability of oil sands processing. In some embodiments, bitumen is combined with biodiluent comprising one or more liquid pyrolysis fractions obtained from pyrolyzing biomass and collecting multiple liquid fractions. The bitumen may be any source of bitumen, such as bitumen obtained from oil sands. In some embodiments, a water-rich pyrolysis liquid displaces water use in an oil sands process. The water-rich pyrolysis liquid may be used for primary separation of bitumen from oil sands or for hydrotransport, for example. Also, biochar produced from biomass pyrolysis may be introduced to an oil sands tailing pond with various benefits. Water may be recycled from a tailing pond. Integration of a pyrolysis and separation process into an oil sands refining process reduces the overall greenhouse-gas emissions on a well-to-refined product basis by 10-70% or more. Various compositions and products are also disclosed. | 2012-11-15 |
| 20120289441 | PROCESS FOR RECOVERING USED LUBRICATING OILS USING CLAY AND CENTRIFUGATION - A process for recovering used industrial and motor lubricating oils. In a first embodiment (for used industrial oils), the used lubricating oil is mixed with clay in a reactor. The mixture is preferably heated to between 105 and 200 degrees Celsius. The temperature should not be too great, to avoid “cracking” the oil (i.e., breaking molecular chains in the oil). After a certain period of time, the mixture is pumped through filters. Cakes of clay and contaminants remain in the filters, while the oil emerges without the contaminants. A second embodiment (for removing ash or soot, very fine carbon particles and other organic compounds from used motor oils) is the same as the first embodiment, except that before the mixture is passed through the filters, a centrifuge is used to remove most of the clay contaminated with soot, so that it will not block the filters. | 2012-11-15 |
| 20120289442 | ARTICLES HAVING LOW COEFFICIENTS OF FRICTION, METHODS OF MAKING THE SAME, AND METHODS OF USE - Embodiments of the present disclosure provide for articles, compositions, methods for making articles, methods of using articles, and the like. Embodiments of the present disclosure relate to articles having superior tribological properties. In particular, embodiments of the present disclosure have a low coefficient of friction and a very low wear rate relative to polytetrafluoroethylene (PTFE). | 2012-11-15 |
| 20120289443 | ALKALI & ALKALINE EARTH THIADIAZOLE ADDITIVES AND LUBRICATING COMPOSITIONS CONTAINING THE SAME - An extreme pressure additive composition for use in grease contains alkaline earth metal derivatives of 2,5-dimercapto-1,3,4-thiadiazole (DMTD) complexed to alkylene glycol fluids and or PAG fluids. In addition, additives for extreme pressure and antiwear contain a complex of alkali and/or alkaline earth metal derivatives of DMTD with alkylene glycol fluids and or PAG fluids, in combination with an organophosphorus compound. | 2012-11-15 |
| 20120289444 | Star Polymer Lubricating Composition - The invention provides a lubricating composition containing (a) 0.001 wt % to 15 wt % of a polymer with radial or star architecture; (b) an overbased detergent; (c) a dispersant; and (d) an oil of lubricating viscosity. The invention further provides a method for lubricating a mechanical device with the lubricating composition. | 2012-11-15 |
| 20120289445 | High Viscosity Lubricant Compositions Meeting Low Temperature Performance Requirements - A lubricant composition characterized as having a viscosity of less than about 150,000 cP at −40° C., a kinematic viscosity of less than about 150,000 cSt at −40° C., and a kinematic viscosity of at least about 18.5 cSt at 100° C. for use in association with a device involving metal to metal contact of moving parts comprising: (a) base-stock comprising (i) at least one relatively low viscosity polyalphaolefin, (ii) at least one ester, and at least one Group III base oil; (b) viscosity improver comprising (i) at least one relatively high viscosity polyalphaolefin, and (ii) a least one olefin copolymer; (c) a performance additive comprising at least one additive effective to improve at least one property of the lubricant and/or the performance of the equipment in which the lubricant is to be used; (d) at least one pour-point depressant; and, optionally, (e) at least one antifoam agent. | 2012-11-15 |
| 20120289446 | COATING REMOVAL COMPOSITION - The present invention is directed to a coating removal composition comprising at least one weak metal binding agent, a solvent system comprising at least one alcohol or ester, and a corrosion inhibition system. A method of removing a coating from an intentionally colored concrete floor is also disclosed. Utilization of the method results in at least 70% retention of colorant component after stripping a coating from an intentionally colored concrete surface, such as a floor. | 2012-11-15 |
| 20120289447 | LIQUID DETERGENT FORMULATION CONTAINING ENZYME AND PEROXIDE IN A UNIFORM LIQUID - A stable, liquid bleach composition is disclosed. The composition comprises a peroxide-component, an enzyme component, and a solvent. | 2012-11-15 |
| 20120289448 | CLEANING COMPOSITIONS EMPLOYING EXTENDED CHAIN ANIONIC SURFACTANTS - The invention discloses synergistic combinations of surfactants blends and cleaning composition. In certain embodiments a surfactant system is disclosed which includes extended anionic surfactants, linker surfactants, and a multiply charged cation component. This system forms emulsions with, and can remove greasy and oily stains, even those comprised of non-trans fats. The compositions may be used alone, as a pre-spotter or other pre-treatment or as a part of a soft surface or hard surface cleaning composition. | 2012-11-15 |
| 20120289449 | LIQUID DETERGENT FORMULATION CONTAINING PEROXIDE, A PEROXIDE STABILIZER, AND A METAL-BASED CATALYST - The invention is an aqueous formulation containing a peroxy component, a peroxide stabilizer comprising a quaternary alkylamino pyridyl compound, and a bleaching catalyst. | 2012-11-15 |
| 20120289450 | Cellulase Variants - The present invention relates to cellulase variants, i.e., endo-beta-1,4-glucanase variants, derived from a parental cellulase, i.e., endo-beta-1,4-glucanase, by substitution, insertion and/or deletion, which variant has a catalytic core domain, in which the variant at position 5 holds an alanine residue (A), a serine residue (S), or a threonine residue (T); at position 8 holds a phenylalanine residue (F), or a tyrosine residue (Y); at position 9 holds a phenylalanine residue (F), a tryptophan residue (W), or a tyrosine residue (Y); at position 10 holds an aspartic acid residue (D); and at position 121 holds an aspartic acid residue (D). | 2012-11-15 |
| 20120289451 | POROUS, DISSOLVABLE SOLID SUBSTRATES AND SURFACE RESIDENT STARCH PERFUME COMPLEXES - The present invention relates to personal care compositions, especially those personal care compositions in the form of a personal care article that is a porous dissolvable solid substrate. The porous dissolvable solid substrate has a surface resident coating comprising the starch perfume complex that can provide a consumer benefit. | 2012-11-15 |
| 20120289452 | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING NECROSIS - A method for treating and/or preventing cell necrosis and diseases associated therewith, comprising the inhibition of one or more elastase enzymes within said cells. | 2012-11-15 |
| 20120289453 | NOVEL GLP-1 COMPOUNDS - Novel GLP-1 compounds and their therapeutic use. | 2012-11-15 |
| 20120289454 | METALLODRUGS HAVING IMPROVED PHARMACOLOGICAL PROPERTIES, AND METHODS OF MANUFACTURE AND USE THEREOF - It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a “ligand moiety”) through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a “metallodrug” or “metallotherapeutic.” The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target. | 2012-11-15 |
| 20120289455 | Monocarbams - The invention relates to compounds of formula (I): | 2012-11-15 |
| 20120289456 | ANTIMICROBIAL PROTEIN COMPOSITIONS AND USES THEREOF - Several bacterial species were isolated from marine segment obtained from seabed sediment at depths exceeding 1700 feet. At least four of the bacteria produced a compound that showed antibacterial activity against one or more multiple-drug-resistant (MDR) bacteria isolated from hospitals and clinics. One isolate, SJCH-12, exhibited a broad range of activity against MDR strains tested, including methicillin resistant | 2012-11-15 |
| 20120289457 | PEPTIDE OLIGONUCLEOTIDE CONJUGATES - Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mRNA splice products produces beneficial therapeutic effects. | 2012-11-15 |
| 20120289458 | TREATMENT OF INFLUENZA VIRUS INFECTION - The present invention provides method for the treatment of an ongoing influenza infection by administering a polypeptide to a subject suffering from an influenza infection. The polypeptide consists of the fusion initiation region (FIR) of an influenza hemagglutinin 2 protein or an 8 to 40 amino acid residue portion thereof. In one embodiment, the polypeptide consists of SEQ ID NO: 4 or an 8 to 40 contiguous amino acid residue portion thereof. The present invention also provides a method of interfering with fusion of an influenza virus envelope with a host cell membrane by contacting the host cell with the FIR polypeptide. | 2012-11-15 |
| 20120289459 | ANTIVIRAL PEPTIDES FROM AFRICAN SWINE FEVER VIRUS WHICH PREVENT THE BINDING OF THE VIRUS TO DLC8 - New antiviral peptides interfering the binding of the virus to DLC8. A high number of pathogenic agents of viral origin use the dynein based intracellular transport machinery at some point of their infective cycle. The present invention consists of a new antiviral therapy consisting in the inhibition of viral infections produced by those virus that use the dynein system by mechanisms of interference mainly by preventing the interaction between the viral protein and the cellular DLC8 protein. The present invention discloses for the first time the blocking of the function of this interaction by peptides whose sequence comprises or consists of the totality or a partial sequence of the viral protein corresponding to the binding domain with DLC8. | 2012-11-15 |
| 20120289460 | Agonists of Guanylate Cyclase Useful for the Treatment of Hypercholesterolemia, Atherosclerosis, Coronary Heart Disease, Gallstone, Obesity and Other Cardiovascular Diseases - This invention also provides a method to prevent, control, and treata lipid metabolism disorder, a biliary disorder, cardiovascular disease, obesity or an endocrine disorder by administering at least one agonist of guanalyte cyclase receptor either alone or in combination with a compound typically used to treat the disorder and or with an inhibitor of cGMP-dependent phosphodieasterases. | 2012-11-15 |
| 20120289461 | PROTEIN SYNTHESIS PROMOTER - A protein synthesis promoter that exhibits a protein synthesis-promoting effect includes a whey protein hydrolyzate having a molecular weight distribution that is within a range of 10 kDa or less and has a main peak of 200 Da to 3 kDa, an average peptide length (APL) of 2 to 8, a free amino acid content of 20% or less, a branched-chain amino acid content of 20% or more, and an antigenicity equal to or less than 1/100,000th of that of β-lactoglobulin. | 2012-11-15 |
| 20120289462 | INSULIN PREPARATION - The present invention relates to an insulin preparation that contains a self-assembling peptide. More specifically, the present invention is an insulin preparation containing a self-assembling peptide of SEQ ID NO: 1. | 2012-11-15 |
| 20120289463 | Compositions and Methods for Promoting Epithelialization and Wound Closure - Compositions for antagonizing phosphorylation and subsequent degradation of glycogen synthase kinase 3 beta (GSK3β) in epidermal cells are disclosed. GSK3β phosphorylation antagonists include molecules that function to inhibit or reduce the binding activity or enzymatic activity of an upstream signaling molecule leading to GSK3β phosphorylation, or by downregulating the expression of one or more upstream signaling molecules involved in regulating GSK3β phosphorylation. Methods of using the GSK3β phosphorylation antagonists to inhibit or reduce the phosphorylation and degradation of GSK3β in epidermal cells are provided. The methods are useful to promote epithelialization and closure of wounds, such as chronic non-healing wounds. | 2012-11-15 |
| 20120289464 | ANGIOGENICALLY EFFECTIVE UNIT DOSE OF FGF-2 AND METHOD OF USE - The present invention provides a unit dose composition comprising 0.2 μg/kg to 48 μg/kg of an FGF-2 of SEQ ID NO:2, or an angiogenically active fragment or mutein thereof in a pharmaceutically acceptable carrier. Also provided is a method for treating a human patient for coronary artery disease, comprising administering into one or more coronary vessels or a peripheral vein of said patient a safe and angiogenically effective dose of a recombinant FGF-2, or an angiogenically active fragment or mutein thereof. Also provided is a pharmaceutical composition comprising a therapeutically effective amount of FGF-2, alone or in combination with heparin, in a therapeutically effective carrier. | 2012-11-15 |
| 20120289465 | USE OF INHALABLE POWDER FORMULATION COMPRISING GROWTH HORMONE FOR PREVENTING OR TREATING NMDA RECEPTOR HYPOFUNCTION-RELATED DISEASES - A use of an inhalable powder formulation for preventing or treating an NMDA receptor hypofunction-related disease, a method for preventing or treating an NMDA receptor hypofunction-related disease in a subject, which comprises administering a therapeutically effective amount of an inhalable powder formulation comprising growth hormone (GH) to the subject in need thereof, and an inhalable powder formulation for preventing or treating an NMDA receptor hypofunction-related disease comprising GH as an active ingredient are provided. | 2012-11-15 |
| 20120289466 | GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) ANALOGUES - GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g., as assessed in in vitro stability assays. More particularly, preferred GLP-2 analogues disclosed herein comprise substitutions at one or more of positions 8, 16, 24 and/or 28 of the wild-type GLP-2 sequence, optionally in combination with further substitutions at position 2 (as mentioned in the introduction) and one or more of positions 3, 5, 7, 10 and 11, and/or a deletion of one or more of amino acids 31 to 33 and/or the addition of a N-terminal or C-terminal stabilizing peptide sequence. The analogues are particularly useful for the prophylaxis or treatment of stomach and bowel-related disorders and for ameliorating side effects of chemotherapy. Also disclosed are methods and kits for selecting a patient from populations suited for treatment with GLP-2 analogues. | 2012-11-15 |
| 20120289467 | Compositions and Methods Utilizing Fibrin Beta Chain Fragments - A composition including a peptide sequence of the formula βX1-X2, the peptide sequence corresponding to an amino acid sequence of a fibrin beta chain fragment of a Bbeta chain of fibrinogen, wherein X1 represents an N-terminal end of the peptide sequence, and X2 represents a C-terminal end of the peptide sequence, wherein the peptide sequence includes additional amino acids between X1 and X2, wherein the peptide sequence may contain a non-naturally occurring amino acid residue, wherein the peptide sequence is other than a wild-type β15-42 monomer sequence per se, and wherein the peptide sequence is other than (β15-66) | 2012-11-15 |
| 20120289468 | VON WILLEBRAND FACTOR (VWF)-CONTAINING PREPARATIONS, AND METHODS, KITS, AND USES RELATED THERETO - The present invention relates to methods, compositions and kits for preparing FVIII and employing same. Also provided are vWF polypeptides and nucleic acid molecules encoding same. | 2012-11-15 |
| 20120289469 | METHODS AND COMPOSITIONS FOR MAINTAINING ACTIVE AGENTS IN INTRA-ARTICULAR SPACES - Methods and compositions for maintaining an active agent in an intra-articular space are disclosed. Methods of delivering the compositions to an intra-articular space and methods of making the compositions also are disclosed. The compositions comprise an active agent and a polymer comprising at least one cationic group. A fluid including the composition may be injected into an intra-articular space in a human or animal whereby the composition associates with endogenous material in the intra-articular space. In some embodiments, the fluid further comprises a poorly aqueous soluble polymer. | 2012-11-15 |
| 20120289470 | TRANSMUCOSAL ADMINISTRATION OF DRUG COMPOSITIONS FOR TREATING AND PREVENTING DISORDERS IN ANIMALS - The invention includes compositions for transmucosal administration to an animal comprising at least one active agent and a pharmaceutically acceptable carrier. A preferred active agent is selected from the group consisting of meloxicam, carprofen, enrofloxacin, clemastine, diphenhydramine, digoxin, levothyroxine, cyclosporine, ondansetron, lysine, zolpidem, propofol, nitenpyram, ivermectin, milbemycin, and pharmaceutically acceptable salts, solvates and esters thereof. In another embodiment, the invention includes methods of treating or preventing a condition in an animal comprising transmucosally administering a composition comprising a therapeutically or prophylactically effective amount of an active agent and a pharmaceutically acceptable carrier. | 2012-11-15 |
| 20120289471 | NOVEL COMPOUNDS WITH HIGH THERAPEUTIC INDEX - The present invention is directed to novel therapeutic compounds comprised of an amino acid bonded to a medicament or drug having a hydroxy, amino, carboxy or acylating derivative thereon. These high therapeutic index derivatives have the same utility as the drug from which they are made, and they have enhanced pharmacological and pharmaceutical properties. In fact, the novel drug derivatives of the present invention enhance at least one therapeutic quality, as defined herein. The present invention is also directed to pharmaceutical compositions containing same. | 2012-11-15 |
| 20120289472 | MOLECULES CAPABLE OF INDUCING CELL DEATH BY TARGETING THE MITOCHONDRIA AND APPLICATIONS THEREOF - The invention relates to the use of derivatives of the membrane insertion regions of proteins of the Bcl-2 family to induce cell death by targeting the mitochondria, characterised in that said derivatives are peptides belonging to regions α5 and/or α6 of the Bax protein or equivalent regions found in the other proteins of the Bcl-2 family. | 2012-11-15 |
| 20120289473 | TREATMENT AND/OR PREVENTION OF INFLAMMATION AND CUTANEOUS PHOTODAMAGE AND PHOTOPROTECTION OF THE SKIN WITH A WATER-SOLUBLE EXTRACT FROM PLANT OF SOLANUM GENUS - The present invention relates to a pharmaceutical composition for preventing and treating inflammation and cutaneous photodamage, which contains a water-soluble extract from a plant of | 2012-11-15 |
| 20120289474 | 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4,3-c] ISOQUINOLINE DERIVATIVES - The compounds of Formula (1), | 2012-11-15 |
| 20120289475 | Certain Compounds, Compositions and Methods - The present invention provides certain tetrahydrouridine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of making and using such compounds. | 2012-11-15 |
| 20120289476 | METHODS FOR TREATING METHYLMALONIC ACIDEMIA - Methods for treating methylmalonic acidemia in which at least one allele of a gene associated with MMA (e.g., the MUT, MMAA, or MMAB gene) contains a mutation (e.g., nonsense mutation) that results in a premature stop codon in RNA encoded by an allele of the gene associated with MMA involving the administration of a compound that promotes readthrough of RNA (e.g., messenger RNA) containing a premature stop codon encoded by an allele of the gene associated with MMA are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment. | 2012-11-15 |
| 20120289477 | BIOTECHNOLOGICAL SULPHATED CHONDROITIN SULPHATE AT POSITION 4 OR 6 ON THE SAME POLYSACCHARIDE CHAIN, AND PROCESS FOR THE PREPARATION THEREOF - A process for the preparation of a chondroitin sulphate salt with an average molecular weight (Mw) of 10-30 kDa via chemical sulphation of an unsulphated chondroitin backbone is provided. The unsulphated chondroitin can be obtained by acid hydrolysis of a capsular polysaccharide K4 made directly from | 2012-11-15 |
| 20120289478 | HYALURONIC ACID ESTERS, THEIR PREPARATION AND USE IN DERMATOLOGY - New ester derivatives of hyaluronic acid with hydroxy-cinnamic acid, their rheological and anti-radical properties are used as protective agents in dermatology. | 2012-11-15 |
| 20120289479 | Materials and Methods Related to Sodium/Potassium Adenosine Triphosphate and Cholesterol - This invention is based in part on the elucidation of new structural conformations and functions of the sodium/potassium adenosine triphosphate synthase (Na/K ATPase), and especially elucidation of new binding sites and interactions. The present invention provides practical applications of several surprising structural and functional relationships between Na/K ATPase and compounds which interact with Na/K ATPase. Disclosure of these structures and relationships provides insight and practical solutions to chemically affecting not only the Na/K ATPase interactions, but also regulators known to be upstream and downstream. | 2012-11-15 |
| 20120289480 | CYCLODEXTRIN-BASED POLYMERS FOR THERAPEUTICS DELIVERY - The present invention relates to novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof. These cyclodextrin-containing polymers improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo. Furthermore, by selecting from a variety of linker groups and targeting ligands the polymers present methods for controlled delivery of the therapeutic agents. The invention also relates to methods of treating subjects with the therapeutic compositions described herein. The invention further relates to methods for conducting pharmaceutical business comprising manufacturing, licensing, or distributing kits containing or relating to the polymeric compounds described herein. | 2012-11-15 |
| 20120289481 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The instant invention provides a method of treating a cancer selected from the group consisting of non-small cell lung cancer and breast cancer with an mTOR inhibitor and an αvβ3 integrin antagonist, wherein the mTOR inhibitor is ridaforolimus, everolimus, temsirolimus or a combination thereof. | 2012-11-15 |
| 20120289482 | Method for modulating or controlling connexin 43(Cx43) level of a cell and reducing arrhythmic risk - A method of modulating or controlling connexin 43 (Cx43) level of a cell includes inducing mitochondrial reactive oxygen species (ROS) production in the cell. | 2012-11-15 |
| 20120289483 | COMPOUNDS FOR THE TREATMENT OF PROLIFERATIVE DISORDERS - The invention relates to compounds of structural formula (I): | 2012-11-15 |
| 20120289484 | PRODRUGS OF TETRAHYDROCANNABINOL, COMPOSITIONS COMPRISING PRODRUGS OF TETRAHYDROCANNABINOL AND METHODS OF USING THE SAME - Described herein are Δ | 2012-11-15 |
| 20120289485 | Metformin Salts of Salicylic Acid and Its Congeners - The present invention relates to compounds, | 2012-11-15 |
| 20120289486 | TREATMENT OF EYELID DERMATITIS - A method for the treatment of eyelid dermatitis and/or dermatitis of the periorbital area is provided. | 2012-11-15 |
| 20120289487 | Pharmaceutical Use of Multicyclic Compounds as Anti-Aids Agents - This invention refers to pharmaceutical use of multicyclic compounds chosen from ingenols, lanosta-8,24-dien-3-ols and their mixtures, as anti-AIDS agents. | 2012-11-15 |
| 20120289488 | Steroid-Sparing Effects of Beta-Adrenergic Inverse Agonists and Uses Thereof - Provided herein is a pharmaceutical composition combination which comprises (a) a corticosteroid and (b) b-adrenergic receptor antagonist characterised in that active ingredients (a) and (b) form part of a single composition. Further provided is a method of treating a human or animal patient suffering from or susceptible to a respiratory disease or condition, said method comprises simultaneously, concurrently, separately or sequentially administering to the patient an effective amount of a b-adrenergic receptor antagonist and a corticosteroid. | 2012-11-15 |
| 20120289489 | NON-SEDATING ANTIHISTAMINE INJECTION FORMULATIONS AND METHODS OF USE THEREOF - Described herein are injectable compositions containing non-sedating or second and third generation antihistamines such as cetirizine/levocetirizine and methods of use thereof. Specifically, methods of treating acute allergic reactions including anaphylaxis with the compositions are disclosed. In certain embodiments, the injectable compositions are bioequivalent to currently marketed oral dosage forms. In other embodiments, the non-sedating or second and third generation antihistamine injectable formulations are therapeutically equivalent to diphenhydramine injectable formulations and/or are more effective than placebo. In other embodiments, a non-sedating antihistamine injectable composition is delivered by an autoinjector. | 2012-11-15 |
| 20120289490 | COMPOSITIONS AND METHODS FOR ENHANCING CORTICOSTEROID DELIVERY - The present invention comprises a composition, method of enhancing potency and method of delivering corticosteroids in a vehicle comprising at least two penetration enhancers, and solvents and emulsifiers. The propylene glycol and penetration enhancers are present in ratio to the total of the propylene glycol, penetration enhancers, and solvents and emulsifiers of at least about 0.70. | 2012-11-15 |
| 20120289491 | METHODS FOR THE TREATMENT OF A CENTRAL NERVOUS SYSTEM INJURY VIA A TAPERED ADMINISTRATION PROTOCOL - The present invention provides methods for the treatment or the prevention of neuronal damage in the CNS. Specifically, the methods of the invention provide for the administration of a therapeutically effective amount of a progestin or progestin metabolite following a traumatic or ischemic injury to the CNS such that, prior to termination of administration of the progestin or progestin metabolite the administration is tapered to avoid withdrawal. The drug taper employed can involve a linear taper, an exponential taper, progressively dividing administered doses by 50%, or can be determined based on the treating physician's assessment of the patient's response to therapy. The tapered administration methods of the present invention may be used in combination with any therapeutic protocol or regimen for the administration of a therapeutically effective amount of a progestin or progestin metabolite to treat a traumatic or ischemic CNS injury. | 2012-11-15 |
| 20120289492 | METHODS OF TREATING MITOCHONDRIAL DISORDERS USING METALLOPORPHYRINS - Methods of treating a mitochondrial disorder including epilepsy, a neurological disorder, an inherited mitochondrial disease or inherited epilepsies, a pediatric epilepsy, an encephalopathy or a pediatric movement disorder are provided, as well as compounds useful in the methods of the invention, such as metalloporphyrin compounds as disclosed herein. | 2012-11-15 |
| 20120289493 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS - The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: | 2012-11-15 |
| 20120289494 | SPIRO-OXINDOLE MDM2 ANTAGONISTS - Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases. | 2012-11-15 |
| 20120289495 | COMPOUNDS AND METHODS - Disclosed are compounds having the formula: | 2012-11-15 |
| 20120289496 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES - The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them. | 2012-11-15 |
| 20120289497 | FUSED PYRIDINE DERIVATIVES - Fused pyridine derivatives shown as the general formula (I), and their pharmaceutically acceptable salts, stereoisomers or solvates thereof are disclosed, which belong to the technical field of medicines. The R | 2012-11-15 |
| 20120289498 | Compositions And Methods Relating To Novel Compounds And Targets Thereof - The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine compounds, and structurally and functionally related compounds, and methods of using such compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, vascular abnormalities, and the like. | 2012-11-15 |
| 20120289499 | PROCESS - Substantially pure methylthioninium chloride pentahydrate form A is prepared from methylthioninium chloride by phase equilibration of suspensions, crystallization or solvent evaporation, whereby the water content of the solvent corresponds to a water activity of at least 0.4 at 25° C., and controlled drying of said methylthioninium chloride pentahydrate form A within its stability ranges of humidity, pressure and temperature. | 2012-11-15 |
| 20120289500 | POTASSIUM CHANNEL MODULATORS - Disclosed herein are KCNQ potassium channels modulators of formula (I) | 2012-11-15 |
