18th week of 2014 patent applcation highlights part 48 |
Patent application number | Title | Published |
20140120449 | FUEL CELL PLATE AND STACK OF CELLS COMPRISING SUCH A PLATE - Fuel cell plate, the reactive face of the plate being provided with reliefs and hollows forming at least one circulation channel for a reagent, the at least one circulation channel for a reagent having an inlet communicating with a reagent distribution orifice formed through the plate, the plate also comprising a reagent inlet collector orifice that is distinct from the reagent distribution orifice, the reagent inlet collector orifice being provided to supply reagent to the inlet of at least one channel via a passage putting in fluid relationship the inlet collector orifice and the reagent distribution orifice, the inlet collector orifice extending longitudinally in the plane of the plate in a first longitudinal direction between a first bottom end and a second top end, the distribution orifice extending longitudinally in the plane of the plate in a second longitudinal direction between a first bottom end and a second top end, the first and second longitudinal directions being parallel to each other and vertical when the plate is in the vertical position of use, characterized in that, in the vertical position of use of the plate, the first bottom end of the inlet collector orifice is situated below the first bottom end of the distribution orifice. | 2014-05-01 |
20140120450 | SOLID OXIDE FUEL CELL MODULE - Disclosed herein is a solid oxide fuel cell module including: a plurality of cylindrical unit cells including a cylindrical internal electrode, an electrolyte, and an external electrode; stack supports including a pair of current collecting plates arranged in parallel and elastic parts changing a gap between the pair of current collecting plates, wherein the stack supports are arranged so as to be in electrical communication with the external electrode of the unit cell. | 2014-05-01 |
20140120451 | GAS DIFFUSION LAYER FOR FUEL CELL AND METHOD FOR MANUFACTURING THE SAME - A gas diffusion layer for a fuel cell includes a gas diffusion layer substrate and a microporous layer formed on the surface of the gas diffusion layer substrate. The microporous layer is formed into a sheet-like shape including a binder and a carbon material containing at least scale-like graphite, and the sheet-like microporous layer is attached to the gas diffusion layer substrate. The gas diffusion layer for a fuel cell having such a configuration, prevents the components included in the microporous layer from entering the gas diffusion layer substrate, so as to ensure gas permeability. In addition, the scale-like graphite contained in the microporous layer as an electrically conductive material improves electrical conductivity and gas permeability. Accordingly, the gas diffusion layer contributes to an improvement in performance of a polymer electrolyte fuel cell. | 2014-05-01 |
20140120452 | FUEL CELL AND MANUFACTURING METHOD THEREOF - A fuel cell of the present invention is configured so that seal members are brought into contact with a frame member, and at least one of the seal member and an outer circumferential portion of the gas diffusion layer is squashed by the other in the thickness direction of a polymer electrolyte membrane, to eliminate a clearance between the gas diffusion layer and the seal member. In this manner, the power generation performance is further enhanced. | 2014-05-01 |
20140120453 | PATTERNED GRAPHITE OXIDE FILMS AND METHODS TO MAKE AND USE SAME - The present invention relates to patterned graphite oxide films and methods to make and use same. The present invention includes a novel strategy developed to imprint any required conductive patterns onto self-assembled graphene oxide (GO) membranes. | 2014-05-01 |
20140120454 | FUEL CELL ELECTRODE CATALYST AND PRODUCTION PROCESS THEREOF - A fuel cell electrode catalyst which includes, at least, M1 that is at least one element selected from 3 to 7 group transition metal elements; M2 that is at least one element selected from iron group elements; M3 that is at least one element selected from 13 group elements; carbon; nitrogen; and oxygen, as constitutional elements, wherein when the atomic ratios of the elements (M1:M2:M3:carbon:nitrogen:oxygen) are represented by a:b:c:x:y:z, 0 | 2014-05-01 |
20140120455 | STABLE PROTON EXCHANGE MEMBRANES AND MEMBRANE ELECTRODE ASSEMBLIES - A proton exchange membrane and a membrane electrode assembly for an electrochemical cell such as a fuel cell are provided. A catalytically active component is disposed within the membrane electrode assembly. The catalytically active component comprises particles containing a metal oxide such as silica, metal or metalloid ions such as ions that include boron, and a catalyst. A process for increasing peroxide radical resistance in a membrane electrode is also provided that includes the introduction of the catalytically active component described into a membrane electrode assembly. | 2014-05-01 |
20140120456 | PERMEATION BARRIER LAYER - A sealable volume has a wall forming at least a portion of a boundary limiting the volume. The wall includes a hydrogen permeation barrier including a layer system (LS) having at least one layer. The layer system includes at least one hydrogen barrier layer (HPBL) of an at least ternary oxide. Preferably, the oxide is substantially composed of Al, Cr and O and the hydrogen barrier layer (HPBL) is deposited using physical vapor deposition, in particular cathodic arc evaporation. Preferably, the layer system includes at least one of: an adhesion layer (AdhL), a hydrogen storage layer (HStL), a protective layer (ProtL), in particular a thermal barrier layer (ThBL), a diffusion barrier layer (DBL), an oxidation barrier layer (OxBL), a chemical barrier layer (ChBL), a wear resistance layer (WRL). Excellent hydrogen permeation barrier properties can be achieved, and the layer system can be tailored as required by an envisaged application. | 2014-05-01 |
20140120457 | LAMINAR STRUCTURE AND A PRODUCTION METHOD FOR SAME - The present invention relates to a laminar structure which is used in a microporous layer, an electrode layer or the like of a membrane electrode assembly for a fuel cell, and also relates to a production method for same. The laminar structure is a laminar structure which is comprised in the membrane electrode assembly (MEA) of a polymer electrolyte membrane fuel cell (PEMFC), and comprises an electrosprayed layer which is formed by the lamination of electrospraying ink, that has been charged by means of an electric field, through an electrospraying process in which the electrospraying ink is dispersed and sprayed as electrospraying liquid droplets, and, in the electrospraying process, the electrospraying substance transmission mode is set in accordance with the adjustment of electrospraying process variables. When the present invention is employed, an optimal substance transmission route is formed and three dimensional structure control is allowed through the electrospraying process and/or an inkjet printing process, and thus it is possible to simultaneously ensure economic advantages and durability when producing a laminated structure which is used in a microporous layer, an electrode layer, or the like of a membrane electrode assembly for a fuel cell. | 2014-05-01 |
20140120458 | Direct Coated Membrane Electrode Assembly On External Reinforcement For Fuel Cells - Disclosed are methods for fabricating a reinforced membrane electrode assembly having one or more freestanding external reinforcement layers. The method comprises providing a freestanding external reinforcement layer, and depositing a catalyst solution and membrane solution onto at least a portion of the freestanding external reinforcement layer. | 2014-05-01 |
20140120459 | METHOD FOR IMPROVING RESIST PATTERN PEELING - A method of fabricating a mask is described. The method includes receiving receiving an integrated circuit (IC) design layout that has a first pattern layer including a first feature and has a second pattern layer including a second feature, wherein the first pattern layer and the second pattern layer are spatially related when formed in a substrate such that the first and second features are spaced a first distance between a first edge of the first feature and a second edge of the second feature, modifying the IC design layout by adjusting a dimension of the first feature based on the first distance, and generating a tape-out data from the modified IC design layout for mask making. The method further includes applying a logic operation (LOP) to the IC design layout. | 2014-05-01 |
20140120460 | PHOTOMASK BLANK AND MANUFACTURING METHOD THEREOF - An object of this invention is to provide a photomask blank in which there is little warpage and is which an amount of warpage change after a photomask manufacturing process ends is also small. First, a phase shift film is deposited (S | 2014-05-01 |
20140120461 | MASK PLATE AND MANUFACTURING METHOD THEREOF - Embodiments of the present invention disclose a mask plate and a manufacturing method thereof. The mask plate includes a mask plate body and a transmissive member, wherein the mask plate body has a transmissive part and a non-transmissive part adjacent to the transmissive part, the transmissive member is disposed corresponding to the transmissive part of the mask plate body, the absorbance of the transmissive member progressively increases in a direction away from a center region of the transmissive member to a edges region of the transmissive member close to the non-transmissive part. | 2014-05-01 |
20140120462 | PHOTOSENSITIVE RESIN COMPOSITION, METHOD FOR FORMING PATTERN-CURED FILM USING PHOTOSENSITIVE RESIN COMPOSITION, AND ELECTRONIC COMPONENT - A photosensitive resin composition including: (a) a polybenzoxazole precursor; (b) a photosensitizer; (c) a solvent; (d) a cross-linking agent; and (e) a heterocyclic compound including a hydroxyl group, an alkoxy group or a carboxyl group within a molecule. | 2014-05-01 |
20140120463 | ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE - Provided is an electrophotographic photoconductor including an electroconductive substrate, a photoconductive layer on the electroconductive substrate, and a protection layer on the photoconductive layer, wherein the protection layer contains two or more metal oxides having different average primary particle diameters, a binder resin, and a charge transporting material, the content of the metal oxides in the protection layer is 50% by mass or higher, and the average primary particle diameters of the metal oxides satisfy all of formulae (I) to (III) below: | 2014-05-01 |
20140120464 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER AND IMAGE FORMING APPARATUS INCLUDING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - A single-layer-type electrophotographic photosensitive member includes a layer disposed on an electrically conductive substrate, the layer including at least a charge-generating material, an electron transport material, a hole transport material, and a binder resin within the same layer. The charge-generating material contains a phthalocyanine pigment and N-type pigments including at least a perylene-based pigment and an azo-based pigment, and the total amount of the N-type pigments is 0.03 to 10 parts by mass relative to 1 part by mass of the phthalocyanine pigment. | 2014-05-01 |
20140120465 | METHOD FOR PRODUCING TONER FOR ELECTROSTATIC IMAGE DEVELOPMENT - A method for producing a toner for electrostatic image development including the step of melt-kneading a mixture containing a resin binder and a wax, wherein the resin binder contains an amorphous polyester (A) obtained by polycondensing an alcohol component containing an aliphatic diol (a) having 3 or 4 carbon atoms, the aliphatic diol having a hydroxyl group bonded to a secondary carbon atom, and an aliphatic diol (b) containing one or more α,ω-linear alkanediols having 2, 4, 6 or 8 carbon atoms, and a carboxylic acid component. The toner for electrostatic image development can be suitably used in, for example, the development or the like of latent image formed in an electrostatic development method, an electrostatic recording method, an electrostatic printing method, or the like | 2014-05-01 |
20140120466 | ELECTROSTATIC LATENT IMAGE DEVELOPING TONER - An electrostatic latent image developing toner includes toner base particles including a binder resin and an external additive attached to surfaces of the toner base particles. The external additive contains silica covered with a coating layer containing a nitrogen containing resin. | 2014-05-01 |
20140120467 | TONER COMPOSITIONS - A toner having charge control agents which impart excellent triboelectric charging characteristics. In embodiments, the toner particles are made by a process in which the toner particles are made without a shell which provides homogenous distribution of the charge control agents, providing a toner with higher charge and better environmental stability | 2014-05-01 |
20140120468 | HEAT TREATING APPARATUS FOR POWDER PARTICLES AND METHOD OF PRODUCING TONER - A production apparatus that does not generate coalesced particles and can reduce a generation frequency of a product having a high circularity by a uniform treatment even if the throughput is increased is provided. A heat treating apparatus for powder particles containing a binder resin and a colorant, the heat treating apparatus including: a treating chamber | 2014-05-01 |
20140120469 | THERMAL ACID GENERATORS FOR USE IN PHOTORESIST - New photoresist compositions are provided that comprise a component that comprises a thermal acid generator and a quencher. Preferred photoresists of the invention may comprise a resin with photoacid-labile groups; a photoacid generator compound; and at least one thermal acid generator and at least one quencher that can function to improve line width roughness and photospeed. | 2014-05-01 |
20140120470 | PHOTORESISTS COMPRISING IONIC COMPOUND - New photoresist compositions are provided that comprise a component that comprises a radiation-insensitive ionic compound. Preferred photoresists of the invention may comprise a resin with photoacid-labile groups; a photoacid generator compound; and a radiation-insensitive ionic compound that can function to decrease undesired photogenerated-acid diffusion out of unexposed regions of a photoresist coating layer. | 2014-05-01 |
20140120471 | PHOTOACID GENERATING COMPOUND AND PHOTORESIST COMPOSITION COMPRISING SAME, COATED ARTICLE COMPRISING THE PHOTORESIST AND METHOD OF MAKING AN ARTICLE - A compound having the formula (I): | 2014-05-01 |
20140120472 | RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, NOVEL COMPOUND, AND ACID GENERATOR - A resist composition including a base component (A) which exhibits changed solubility in an alkali developing solution under action of acid and an acid-generator component (B) including a compound represented by (b1-1), a compound represented by (b1-1′) and/or a compound represented by (b1-1″) (R | 2014-05-01 |
20140120473 | COLORED RADIATION-SENSITIVE COMPOSITION FOR COLOR FILTER, PATTERN FORMING METHOD, COLOR FILTER AND METHOD OF PRODUCING THE SAME, AND SOLID-STATE IMAGE SENSOR - A colored radiation-sensitive composition for a color filter that includes (A) a pigment, (B) a photopolymerization initiator, and (C) a polymerizable compound, in which the colored radiation-sensitive composition satisfies the following conditions: when a colored radiation-sensitive composition layer is formed from the colored radiation-sensitive composition such that spectral transmittance at 600 nm becomes 30%, the colored radiation-sensitive composition layer includes the following characteristics: (1) spectral transmittance at 400 nm is 20% or less; (2) spectral transmittance at 550 nm is 10% or less; (3) spectral transmittance at 700 nm is 70% or more; (4) a wavelength resulting in 50% spectral transmittance is in a range of from 650 nm to 680 nm; and (5) a film thickness of the colored radiation-sensitive composition layer is in a range of from 0.55 μm to 1.8 μm. | 2014-05-01 |
20140120474 | Deep-Ultraviolet Chemically-Amplified Positive Photoresist - The invention discloses a deep-ultraviolet chemically-amplified positive photoresist. The deep-ultraviolet chemically-amplified positive photoresist according to one embodiment of the invention includes a cyclopentenyl pimaric acid, a divinyl ether, a photoacid generator and an organic solvent. The deep-ultraviolet chemically-amplified positive photoresist according to the invention has a good sensitivity and a good transparency. | 2014-05-01 |
20140120475 | ELECTRON BEAM EXPOSURE METHOD - An electron beam exposure method includes the steps of: preparing an exposure mask having a plurality of opening patterns formed by dividing a drawing object pattern into exposable regions; and drawing the drawing object pattern by performing exposure with an electron beam passing through the opening patterns of the exposure mask. Each end portion serving as a joint in each opening pattern of the exposure mask is provided with a joining portion tapered in a width of the opening pattern. The exposure is performed in such a way that portions drawn through adjacent joining portions overlap each other. | 2014-05-01 |
20140120476 | Method of forming a photoresist pattern - A method of forming a photoresist pattern, in which, a substrate is coated with a photoresist layer, an exposure process is performed on the photoresist layer to expose the photoresist layer, the photoresist layer is rinsed with a surfactant after the exposure process is performed, and the photoresist layer is post-exposure baked after the photoresist layer is rinsed with the surfactant. | 2014-05-01 |
20140120477 | SUBSTRATE PROCESSING APPARATUS - A method of processing a substrate in a substrate processing apparatus that is arranged adjacent to an exposure device and includes first, second and third processing units, includes forming a photosensitive film on the substrate by said first processing unit before exposure processing by said exposure device and applying washing processing to the substrate by supplying a washing liquid to the substrate in said second processing unit after the formation of said photosensitive film and before the exposure processing. The method also includes applying drying processing to the substrate in said second processing unit after the washing processing by said second processing unit and before the exposure processing and applying development processing to the substrate by said third processing unit after the exposure processing. Applying the drying processing to the substrate includes the step of supplying an inert gas onto the substrate, to which the washing liquid is supplied. | 2014-05-01 |
20140120478 | TECHNIQUES FOR PATTERNING RESIST - A technique for patterning a substrate is disclosed. In accordance with one exemplary embodiment, the technique may be realized as a method for patterning a substrate. The method may comprise: providing a resist on the substrate; introducing one or more species of impurities into the resist; selectively exposing a first portion of the resist to radiation while a second portion of the resist is not exposed to the radiation; exposing the resist to a developer and removing the first portion of the resist exposed to the radiation from the substrate; and exposing the resist at a temperature higher than a room temperature but lower than glass transition temperature of the resist. | 2014-05-01 |
20140120480 | Gas burner for a household appliance - A compact thermoelectric safety actuator having a first body with a first cavity and a second body with a second cavity. The first and second bodies are connected so that the first and second cavities are arranged facing and open to one another. The first body has a gas outlet and the second body has a gas inlet in fluid communication with the gas outlet through the second cavity, An electromagnet of the actuator has a first end portion residing in the first cavity and a second end portion residing in the second cavity. A rotatable arm has a first end with a ferromagnetic frame adapted to engage the second portion of the electromagnet and a second end coupled to a sealing member, each of the tilting arm, ferromagnetic frame and sealing member are arranged in the second cavity. The first sealing member is configured to seat against a seating located on the first body when the arm is in a rest position, the first seating being located between the gas outlet and the second cavity. | 2014-05-01 |
20140120481 | Lighter With Flame Director - An adjustable lighter in which the flame angle is controlled by a switch located on the lighter a safe distance from the flame. In one embodiment, a thumb slide switch is used to rotate the flame output to one or more flame angles. An alternative embodiment uses a flame output in the form of in the form of a wheel. An optional features include an integral LED lamp, and/or a transparent window that allows the user to view the inside of the lighter. | 2014-05-01 |
20140120482 | Ceremonial Candle and Sand Apparatus - Embodiments of the invention generally provide an enclosure | 2014-05-01 |
20140120483 | Local Heat Treatment and Thermal Management System for Engine Components - A method of thermal management includes positioning a first workpiece and a second workpiece in at least one tool having internal cavities, passing a fluid into at least one of the internal cavities to cool portions of the first and second workpieces, welding the first workpiece and the second workpiece in the at least one tool by resistance heating to form a joined workpiece, controlling a rate of cooling of the joined workpiece to slow a rate of cooling through at least one of a resistive heat element or welding electrode of the at least one tool. A localized thermal management tool includes a mounting block, a first heater block having a first workpiece engagement surface, a second heater block having a second workpiece engagement surface, a resistive heater mounted within at least one of the first heater block and the second heater block, a first cooling clamp engaging the mounting block and the first heater block, a second cooling clamp engaging the mounting block and the second heater block, a cooling fluid conduit disposed in at least one of the first and second cooling clamps, an insulator between each of the heater blocks and the cooling clamps. | 2014-05-01 |
20140120484 | FLUE DAMPER CONTROL ALGORITHM FOR STANDING PILOT TYPE FUEL-FIRED WATER HEATER - In a fuel-fired water heater with a standing pilot burner and a motorized flue damper, a specially designed controller is utilized to prevent overheating of water stored in the tank portion of the water heater caused by the hot combustion gases continuously generated by the pilot burner during standby periods of the water heater in which its main fuel burner is not being fired. The controller has a selectively variable water temperature control set point temperature and is operable to sense both ambient temperature and the tank water temperature and to open the flue damper and/or keep it open, after the main burner is off, in response to the presence for a predetermined continuous time period of a predetermined relationship of at least the selected temperature control set point temperature and the sensed ambient temperature | 2014-05-01 |
20140120485 | Furnace Assembly - Provided are peptide analogues of PA-IL and compositions containing them. The PA-IL peptide analogues have altered carbohydrate binding specificity relative to a PA-IL of SEQ ID NO:1, and thus the analogues contain amino acid substitutions in SEQ ID NO:1. The substitutions can be at positions 50, 52 and 53 of SEQ ID NO:1 and can include combinations of amino acid substitutions at those positions. Also included are methods for detecting changes in the glycosylation of carbohydrates and for separating biomolecules which contain glycoproteins or glycoconjugates. | 2014-05-01 |
20140120486 | CEMENT PLANT - There is provided a cement plant including a chlorine bypass apparatus capable of efficiently reducing the chlorine concentration in a cement kiln due to exhaust gas extraction by a small amount, by preventing calciner exhaust gas low in chlorine concentration from contamination and extracting a part of kiln exhaust gas high in chlorine concentration. In the invention, a baffle wall | 2014-05-01 |
20140120487 | HEAT TREATMENT APPARATUS - Provided is a heat treatment apparatus, which includes: a cylindrical quartz reaction tube having a furnace opening and a bottom flange at a lower portion thereof; a flange holding part configured to hold the bottom flange of the reaction tube; and a lid including a metal lid and a quartz lid supported by the metal lid, the quartz lid being configured to close the furnace opening of the reaction tube. The quartz lid is fixed onto the metal lid by a support ring. The support ring is brought into contact with a bottom surface of the flange holding part so that a gap is defined between the quartz lid and the bottom flange. A sealing member is arranged outward from the gap in a radial direction. | 2014-05-01 |
20140120488 | Orthodontic Treatment Aligners Based on CT Data - A system and method for orthodontic alignment includes a radiographic template. The radiographic template has a plurality of metallic markers. A negative impression of a patient's dental arch is made. At least one orthodontic treatment aligner is produced. The aligner is manufactured based in part on a computed axial tomography (CT) scan of a patient wearing the radiographic template and a separate scan of the radiographic template, wherein the data is processed by superimposition of the orthodontic aligner on the CT images of the patient including a jaw in axial and panoramic views. In this manner, the tooth above the gum line, represented by the negative impression as well as the tooth below the gum line, represented by the CT data is used to design the orthodontic aligner. | 2014-05-01 |
20140120489 | ORTHOSIS COMPRISING AN UPPER TRAY AND A LOWER TRAY, AND CONNECTION WITH ADJUSTABLE POSITIONING - An orthosis includes an upper tray and a lower tray, which are designed to line the teeth of an upper jaw and the teeth of a lower jaw, respectively. A connection joins the trays. The upper tray has at least a first fixed base, and the lower tray has at least a second fixed base. The connection has a fixed length and is designed to be fixed, on the one hand, to the first base and, on the other hand, to the second base, in a position that has an advancing effect and that is adjustable by way of a control element integrated in at least one of the two bases. | 2014-05-01 |
20140120490 | AUTOMATIC PLACEMENT OF PRECISION CUTS - An orthodontic positioning device and methods for making an orthodontic positioning device including a first patient removable orthodontic tooth positioning appliance having teeth receiving cavities shaped to receive and apply a resilient positioning force to a patient's teeth provided in one of an upper jaw and a lower jaw. The first appliance includes a hook configured to receive an orthodontic elastic band. The orthodontic positioning device also includes a second patient removable orthodontic tooth positioning appliance having teeth receiving cavities shaped to receive and apply a resilient positioning force to a patient's teeth provided in the other of the upper jaw and the lower jaw. The second appliance includes a cutout operable to expose an orthodontic elastic band receiving member. | 2014-05-01 |
20140120491 | ORTHODONTIC APPLIANCE WITH SNAP FITTED, NON-SLIDING ARCHWIRE - An orthodontic appliance may include an archwire and multiple orthodontic brackets. The archwire may fit within a human mouth and contain multiple male connectors. Each orthodontic bracket may have a configuration that facilitates attaching the orthodontic bracket to a single tooth. Each orthodontic bracket may allow one of the male connectors to be locked into the orthodontic bracket with a snapping action. The male connector may be unable to slide with respect to the orthodontic bracket after being locked in the orthodontic bracket. A manual unlocking action may allow the male connector to disengage from the orthodontic bracket. | 2014-05-01 |
20140120492 | PERIODONTAL PROBE WITH TOUCH SENSING - A periodontal probe is provided for measuring a depth of a periodontal pocket using a touch sensor. The periodontal probe includes a handle with a probe tip for insertion into the periodontal pocket. The probe tip includes a touch sensitive reader located on or near an exterior surface thereof for measuring contact between the exterior surface of the probe tip and the tissue of the periodontal pocket. A touch sensor and a microcontroller are connected to the touch sensitive reader to measure the amount of contact between the touch sensitive reader and the tissue of the periodontal pocket, which corresponds to the depth of the periodontal pocket. | 2014-05-01 |
20140120493 | MOTION COMPENSATION IN A THREE DIMENSIONAL SCAN - The present disclosure provides computing device implemented methods, computing device readable media, and systems for motion compensation in a three dimensional scan. Motion compensation can include receiving three-dimensional (3D) scans of a dentition, estimating a motion trajectory from one scan to another, and calculating a corrected scan by compensating for the motion trajectory. Estimating the motion trajectory can include one or more of: registering a scan to another scan and determining whether an amount of movement between the scans is within a registration threshold; determining an optical flow based on local motion between consecutive two-dimensional (2D) images taken during the scan, estimating and improving a motion trajectory of a point in the scan using the optical flow; and estimating an amount of motion of a 3D scanner during the scan as a rigid body transformation based on input from a position tracking device. | 2014-05-01 |
20140120494 | APPARATUS AND METHOD FOR ORAL AND MAXILLOFACIAL SURGERY AND PREOPERATIVE MODELING - A head frame apparatus is secured to a human head during maxillofacial surgery and includes devices to easily position and secure an endotracheal (breathing) tube and an anesthesia delivery circuit for the patient that reduces the likelihood that the flow of oxygen through the tube is restricted thereby reducing the risk of severe injury or death. The head frame apparatus also includes a removable reference indicator, which may be easily attached and removed while identifying a reference point of the patient's face. Also the reference indicator includes a universal joint and pointer with an attached ruler. A transport apparatus positions multiple preset reference indicators and allows for preoperative transportation and removal, while protecting the preset reference indicators from inadvertent adjustment. A bendable reference indicator used in an articulator for preoperative modeling allows for easily identifying reference points in a cast model. An orbiting segment apparatus positions a portion of a cast of a jaw in relation to a condyle ball of the articulator. | 2014-05-01 |
20140120495 | DEPTH STOP FOR SURGICAL INSTRUMENTS - A surgical tool or instrument having a plurality of depth stop positions, settings or locations, allowing for depth adjustment or a limitation of the allowable extension of a working tool coupled to or used in combination with the instrument. In example forms, an appliance or mouthpiece provides a guide to retain the surgical instrument to a particular orientation, and a stop member coupled to the tool or instrument in at least one of the plurality of depth stop positions, settings or locations determines the extension of the working tool therein. | 2014-05-01 |
20140120496 | METHOD FOR CONTROLLING AND/OR REGULATING A COMPRESSED-GAS-OPERABLE MEDICAL DRIVE DEVICE AND SUCH A DRIVE DEVICE - Methods for controlling and/or regulating of a compressed-gas-operable medical or dental drive device and a control and/or regulating device for performing such methods are described. In one method according to a first embodiment, a rotor of the drive device is operated at an essentially constant rotational speed (n | 2014-05-01 |
20140120497 | DENTAL SEPARATOR APPARATUS AND METHOD - A tooth separator apparatus, according to one embodiment, includes a tong having two resilient arms that are biased in an open position and having a wedge at each end of each arm. A drive shaft moves a compression member to overcome the resiliency of the arms and move them and the wedges in a closing direction for separating the teeth. The drive shaft can also move the compression member in the opposite direction to release the closing force on the arms and thereby permit their resiliency to allow them and the wedges to move to an open position. | 2014-05-01 |
20140120498 | DENTAL IMPLANT AND DENTAL IMPLANT SYSTEM - A dental implant with a receiver for dental mounting parts is disclosed. The receiver comprises at least one cylindrical wall portion and the dental implant has a support face perpendicular to the longitudinal axis, so that a corresponding first mounting part can be radially supported on the at least one cylindrical wall portion and axially on the support face. The receiver furthermore comprises at least one truncated-cone-shaped wall portion, on which a corresponding second mounting part can be radially and axially supported. A dental implant system is also disclosed, comprising the dental implant and at least one first and at least one second dental mounting part, which can selectively be connected to the dental implant. | 2014-05-01 |
20140120499 | DENTAL VISIBLE-LIGHT CURABLE COMPOSITION AND METHOD OF IDENTIFYING PRESENCE OF SAME - A dental curable composition that allows easily identifying the presence of the dental curable composition in an oral cavity is provided. A dental visible-light curable composition contains a fluorescent substance that generates fluorescence when irradiated with visible light. The fluorescent substance is a compound of formula A | 2014-05-01 |
20140120500 | INTEGRATED FLIGHT TRAINING AND EVALUATION SYSTEMS AND METHODS FOR HANDHELD AND PORTABLE NAVIGATION DEVICES - Systems and methods are described for evaluating maneuvers of an aircraft. In one embodiment, a method comprises performing steps on one or more processors. The steps comprise: setting a mode of a handheld device to a training mode. When in the training mode, the steps comprise tracking realtime flight data; retrieving standards data based on a maneuver type associated with the realtime flight data; and evaluating the realtime flight data based on the standards data. | 2014-05-01 |
20140120501 | BEADING BOARD DEVICE FOR A TABLET COMPUTER AND TABLET COMPUTER PROGRAM FOR USE WITH SAME - A beading board for arranging cylindrical beads in a pattern displayed on an electronic display device. The beading board includes a frame configured to receive the electronic display device, and a board including a plurality of bead receivers. The board is cooperatively received by the frame and configured to be supported over the electronic display device such that the electronic display device is viewable through the board. A system and method for generating and displaying a beading pattern on the electronic display device is also provided. | 2014-05-01 |
20140120502 | LANGUAGE LEARNING USING ELECTRONIC BOOK - A language learning method utilizing an interactive electronic book. The interactive book may display two identical pages, one page displaying text in the user's native language and the corresponding page displaying the appropriate translation in the target language. Selection of native-language text results in hearing the material as it normally or casually spoken in the target language. Illustrations may supplement the text and reinforce understanding of the depicted actions. | 2014-05-01 |
20140120503 | METHOD, APPARATUS AND SYSTEM PLATFORM OF DUAL LANGUAGE ELECTRONIC BOOK FILE GENERATION - The system platform and methods of the present disclosure brings the dual language concept to electronic books in a manner enhanced for both visual and aural learners. A method can include creating a correspondence between a first language text and a second language text. The method can include creating a correspondence between the first language text and an audio recording of the first language text. The method can include generating a dual language electronic book file comprising the first language text, the second language text, the correspondence between the first language text and the second language text, and the correspondence between the first language text and the audio recording of the first language text. An application for electronic book reading devices displays the text while playing the audio recording, maximizing the number of fragments of the first and second language texts based on one or more display variables. | 2014-05-01 |
20140120504 | BOOK ASSEMBLY WITH SLIDER-ACTIVATED SWITCH - A book assembly with a track, a slider, and a switch. The slider is visible and can be slid along the track by a user such as a child. The switch is activated by moving the slider in the track. Activating the switch plays a sound or lights a light. | 2014-05-01 |
20140120505 | SYSTEM FOR COSMETIC AND THERAPEUTIC TRAINING - Systems and methods are disclosed for an apparatus and method for practicing injection techniques through an injectable apparatus. The injectable apparatus may contain a camera that is configured to detect the intensity and color of light attenuated from a testing tool after it is injected into a simulated human or animal body parts. A training tool may be connected to a user display device to generate a display of the injection apparatus as well as the performance parameters of a trainee. | 2014-05-01 |
20140120506 | SCENT MEMORY STRIP - A scent memory strip, which may be called a “Smemory Strip”, includes a malleable and rigid strip of material; a first scent concentrated portion at a first end of the strip; a second scent concentrated portion at a second end of the strip; wherein the strip is adapted to conform to and grip a user's columella so that the strip is retained to the columella; and the strip is adapted to provide a particular scent to the user so that the scent is first associated with a memory when the strip is first used and the scent will be second associated with the same memory at a later time. | 2014-05-01 |
20140120507 | Psyche Trainer and Method of Use - A psyche trainer has at least one spherical body positioned within a container. The container is attached to a cord, such that the psyche trainer can be worn on a desired appendage of a user. A goal is determined by the user and associated with the psyche trainer. As the user moves, the at least one spherical body traverses along the interior of the container, creating vibrations. The vibrations are registered in the user's brain and act as reminder of the goal, assisting the user in becoming self aware of their goal. The psyche trainer can also be designed to create an audible noise to further assist in becoming self aware of one's goal. As an alternative to being worn by the user, the container may be attached to a support base, such that the psyche trainer may be attached to a variety of objects. | 2014-05-01 |
20140120508 | METHOD FOR EFFECTING CHANGES IN AN INDIVIDUAL'S BEHAVIOR OR MENTAL STATE - A method for effecting changes in a subject's behavior or mental state comprising wherein background and preparation work is performed on the subject by engaging the subject in conversation and asking probing questions, getting the subject to the point where the subject feels his or her emotions; and, having the subject feel the emotion the way it wants to be felt. | 2014-05-01 |
20140120509 | Swallowing Simulation Apparatus and Method - To provide a swallowing simulation apparatus that facilitates approximate reproduction of an actual phenomenon of swallowing. | 2014-05-01 |
20140120510 | METHODS and SYSTEMS for ENCOURAGING END-OF-LIFE PLANNING - A method for encouraging end-of-life planning. The method includes accessing a computer server having a computer-readable storage medium. The method further includes retrieving a plurality of web documents from the computer server. Each web document includes at least one question directed to end-of-life issues. The method further includes entering data into the web documents. The data is configured to be at least one answer to at least one of the questions. The method further includes incorporating the at least one answer into a template configured to be easily understood. | 2014-05-01 |
20140120511 | TeachAtCafe - TeaChatCafe, Transparent Digital and Social Media as an Open Network Communication and Collaboration Tool with User Driven Content and Internet Content Submission Capability for Educators and Their Students - A method, systems, and computer programming products that support transparent, safe online communication and collaboration for educators and their students participating in any K-12 or higher-education institutions. A software application is provided as a framework that allows teachers and students to reach out to one another digitally and from a variety of social media technologies without social entanglement and in a completely transparent way. This invention provides a method, system and software application that pushes all chatting/texting/messages and other user driven content between two users to a monitoring portal that allows school administrators and parents to view all digital communication between their students and educators. In addition, automated keyword searches run in the background that will alert monitors of misconduct or inappropriate language. All system registrants are informed and agree to the transparent dialog before use. | 2014-05-01 |
20140120512 | INTERNET-BASED EDUCATIONAL FRAMEWORK FOR THE CORRELATION OF LESSONS, RESOURCES AND ASSESSMENTS TO STATE STANDARDS - An apparatus assists educators in selecting achievement tools to meet an applicable one of a plurality of sets of educational standards. A first table holds a plurality of educational standards and a plurality of linked keywords. A second table holds a plurality of achievement tools, such as lesson plans, assessments and resources, and a plurality of linked keywords. A table manipulator program permits an educator to select an educational standard and shows achievement tools applicable to the selected educational standard by having a matching of keywords linked to the achievement tools to keywords linked to the educational standards. | 2014-05-01 |
20140120513 | Question and Answer System Providing Indications of Information Gaps - Mechanisms are provided for identifying information gaps in electronic content. These mechanisms receive the electronic content to be analyzed and analyze the electronic content to identify at least one of topics or questions within the electronic content to produce a collection of at least one of topics or questions associated with the electronic content. These mechanisms further compare the collection to the electronic content, and to a corpus of previously analyzed electronic content, to produce a set of information gaps in the electronic content. Moreover, the mechanisms output a notification of the set of information gaps to a user associated with the electronic content. | 2014-05-01 |
20140120514 | Cloud Learning System Capable of Enhancing Learner's Capability Based on Then-Current Contour or Profile of Levels or Capabilities of the Learner - A cloud learning system capable of enhancing learner's capability based on then-current contour or profile of levels or capabilities of the learner provides tests about a subject, a skill or expertise in advance to determine then-current contour or profile of capability of the test-taker. Then learning data or material is provided to a user for training, while the learning data or material is based on the test points or formats for the test implicitly or explicitly, contained or hidden in the test questions so as to enhance some weak areas of the user detected or diagnosed in the test. The capability of the learner is enhanced and the user has higher confidence to learn the subject, the skill or the expertise further. The structure can be constructed in a cloud network structure. External content-providers can provide their teaching material to the dedicated database based on specific test points or formats. | 2014-05-01 |
20140120515 | IDENTIFICATION FOR PERFORMING TASKS IN OPEN SOCIAL MEDIA - Embodiments of the invention relate to user identification in social media for task performance based on past usage and traits. One embodiment includes identifying users of a social media platform for ability of performing a task. Readiness scores are predicted based on past usage of the social media platform. A predicted readiness score includes a value corresponding to whether a user is predicted to be ready for performing the task. Users that are ready to perform the task are determined based on comparing the readiness scores with a threshold. Willingness scores for performing the task by the users determined to be able and ready to perform the task are determined. A willingness score includes a value corresponding to whether a user is estimated to be willing for performing the task. Users that are willing to perform the task are determined based on comparing the willingness scores with a threshold. | 2014-05-01 |
20140120516 | Methods and Systems for Creating, Delivering, Using, and Leveraging Integrated Teaching and Learning - The present invention is directed to methods and systems that redefine how a course is taught and how material is learned in a large-scale class environment. In this system, there is adaptation of content presentation for each student, based on the tracking, learning, and profiling of student learning efficiency. Furthermore, the textbook of the present invention can be created during the delivery of course content, and sold at a variety of granularity. | 2014-05-01 |
20140120517 | CHALLENGE BASED INNOVATION SYSTEM - A challenge-based innovation kit includes a first piece and a second piece. The first piece includes a hub member and a wheel member. The wheel member is rotatably coupled to the hub member. The hub member defines a first mount portion. The wheel member defines a second mount portion opposing the first mount portion. The second piece includes a plurality of third mount portions for coupling the second piece to the first mount portion or the second mount portion. | 2014-05-01 |
20140120518 | TEACHING GESTURES WITH OFFSET CONTACT SILHOUETTES - A method for providing multi-touch input training on a display surface is disclosed. A touch/hover input is detected at one or more regions of the display surface. A visualization of the touch/hover input is displayed at a location of the display surface offset from the touch/hover input. One or more annotations are displayed at a location of the display surface offset from the touch/hover input and proximate to the visualization, where each annotation shows a different legal continuation of the touch/hover input. | 2014-05-01 |
20140120519 | Automated Pattern Generation Processes - An automated system for generating large numbers of digitally-defined patterns suitable for printing on textiles wherein each pattern is individually different but shares one or more unifying design motifs with all other patterns. In the general case, each pattern is comprised of at least two components in the form of separately configurable pattern layers that are digitally superimposed to form a composite pattern that is unique but visually related to all other unique patterns that use pattern layers taken from the same pattern sources. | 2014-05-01 |
20140120520 | Desiccated Biologics And Methods Of Preparing The Same - The present invention provides compositions comprising desiccated biologics comprising a cell, protein, virus, nucleic acid, carbohydrate, or lipid, or any combination thereof, along with at least one membrane penetrable sugar, and at least one membrane impenetrable sugar, wherein the moisture content is from 5% to 95%, and to methods of preparing the same, and to methods of treating animals using the same. | 2014-05-01 |
20140120521 | MICROFLUIDIC DEVICE, MICROFLUIDIC SYSTEM AND METHOD FOR CONTROLLING MICROFLUIDIC TEST DEVICE - A microfluidic device, a microfluidic system and a method for controlling a microfluidic test device are provided. The microfluidic device includes a rotatable platform including a sample chamber to which a sample is supplied, a first reagent chamber; a first capture conjugate disposed in the first reagent chamber and configured to capture a target material contained in the sample; a second reagent chamber; a signal material disposed in the second reagent chamber and configured to be electrochemically induced by the first capture conjugate; a reaction chamber providing an area in which a biochemical reaction between the sample and the signal material supplied occurs when the platform rotates; a second capture material disposed in the reaction chamber and configured to capture the target material; a detection chamber separated from the reaction chamber, the detection chamber comprising a detector configured to detect an electrochemical signal generated by the signal material; and a plurality of channels connecting the chambers. | 2014-05-01 |
20140120522 | NANOFLUIDIC DEVICES FOR SINGLE-MOLECULE ANALYSIS OF PROTEIN-DNA COMPLEX - A device for optical mapping of protein binding sites, in particular, transcription factor binding sites, on single DNA molecules, includes an insulating substrate having two parallel channels and at least one slit connecting the two channels, a coverslip on the substrate, at least two reservoirs on the substrate connecting the channels of the insulating substrate, and at least two electrodes in the reservoirs. When the reservoirs are filled with a buffer solution, the electrodes are in electrical contact in the buffer solution. | 2014-05-01 |
20140120523 | NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES - This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease. | 2014-05-01 |
20140120524 | In-Situ Pathogen Detection Using Magnetoelastic Sensors - In at least one illustrative embodiment, a method for in-situ pathogen detection may comprise distributing one or more magnetoelastic measurement sensors on a surface of a test object, wherein each of the one or more magnetoelastic measurement sensors includes a biorecognition element configured to bind with a pathogen to cause a shift in a characteristic frequency of the associated measurement sensor; applying a varying magnetic field, using a test coil, to the one or more magnetoelastic measurement sensors distributed on the surface of the test object, wherein the test object is positioned outside of an inner volume defined by the test coil; detecting a frequency response of the one or more magnetoelastic measurement sensors using the test coil, while applying the varying magnetic field; and determining whether the pathogen is present based on the detected frequency response of the one or more magnetoelastic measurement sensors. | 2014-05-01 |
20140120525 | MONITORING AND INHIBITING HUMAN IMMUNODEFICIENCY VIRUS INFECTION BY MODULATING HMGB1 DEPENDENT TRIGGERING OF HIV-1 REPLICATION AND PERSISTENCE - Compositions and methods for modulating human immunodeficiency virus (HIV) infection involving substances that inhibit the ability of high mobility box 1 (HMGB1) protein to interact with natural killer (NK) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to HMGB1. Methods of detecting or monitoring HIV infection involving detection or quantitation of HMGB1 or antibodies specific for HMGB1 in a biological sample. | 2014-05-01 |
20140120526 | METHODS, COMPOSITIONS, AND KITS FOR DETERMINING HUMAN IMMUNODEFICIENCY VIRUS (HIV) - The present invention relates to compositions, methods, and kits for determining the presence or absence of HIV in a sample, in particular for determining HIV-1 group M, HIV-1 group O, and/or HIV-2, in particular for simultaneous determining of HIV-1 group M, HIV-1 group O, and HIV-2. | 2014-05-01 |
20140120527 | Nuclear localization of Src-family tyrosine kinases is required for growth factor-induced euchromatinization - A method for quantitatively evaluating chromatin structural changes using pixel imaging of the nucleus is provided. Pixel imaging of the nucleus can include capturing one or more images of a nucleus of one or more nucleic acid stain treated cells. The stain intensity can be measured by quantitating the intensity. The mean and/or standard deviation of stain intensity per pixel can be used to determine chromatin condensation levels or chromatin structural change. | 2014-05-01 |
20140120528 | Methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome - The invention relates to methods and biomarker for evaluating cancer metastasis, pharmaceutical composition for inhibiting cancer metastasis, and method for analyzing secretome. By combining a hollow fiber cartridge (HFC) culture system with quantitative proteomics technology, cancer metastasis-related secrectomes can be found. Furthermore, this is the first time to use PARK7 as a biomarker for judging the process of non-small cell lung cancer. | 2014-05-01 |
20140120529 | COMPOSITIONS, METHODS, SYSTEMS AND KITS FOR TARGET NUCLEIC ACID ENRICHMENT - The present invention provides methods, compositions, kits, systems and apparatus that are useful for isolating nucleic acid molecules from a sample. In particular, the methods generally relate to normalizing the concentration of target nucleic acid molecules from a sample. In one aspect, the invention relates to purifying a primer extension product from a primer extension reaction mixture. In some aspects, nucleic acid molecules obtained using the disclosed methods, kits, systems and apparatuses can be used in various downstream processes including nucleic acid sequencing. | 2014-05-01 |
20140120530 | METHOD FOR CLASSIFYING/COUNTING LEUKOCYTES, REAGENT KIT FOR CLASSIFYING LEUKOCYTES, AND REAGENT FOR CLASSIFYING LEUKOCYTES - The present invention provides a method for classifying and counting leukocytes which allows classification and count of normal leukocytes as well as discrimination between blast cells and atypical lymphocytes. The present invention also provides a regent kit and reagent for classifying leukocyte which are used for classifying and counting leukocytes in biological samples. | 2014-05-01 |
20140120531 | Devices, Solutions and Methods for Sample Collection - The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery. | 2014-05-01 |
20140120532 | METHOD OF SEQUENTIAL AND MULTIPLE IMMUNOSTAINING FOR DETECTION OF VARIOUS ANTIGENS IN THE SAME SPECIMENS - Provided herein is a method of sequential and multiple immunostaining for detection of various antigens in the same specimens, which may be used for qualitative or quantitative analysis of proteins expressed, gene analysis, and morphological analysis even in specimens where only a small amount is available. | 2014-05-01 |
20140120533 | GENETIC POLYMORPHISMS ASSOCIATED WITH CARDIOVASCULAR DISEASES, METHODS OF DETECTION AND USES THEREOF - The present invention provides compositions and methods based on genetic polymorphisms that are associated with cardiovascular diseases, particularly coronary heart disease (especially myocardial infarction) or hypertension. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection. | 2014-05-01 |
20140120534 | METHODS FOR IDENTIFYING NUCLEIC ACID SEQUENCES - Embodiments relate to the detection of RNA in a sample of cells. More particularly, methods concern the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ. In additional methods, rolling circle amplification products are sequenced. | 2014-05-01 |
20140120535 | METHODS AND KITS FOR PERFORMING IN SITU HYBRIDIZATION - The invention relates to methods and kits for performing in situ hybridization on a biological sample on a solid surface using nucleic acid probes that are embedded in or sorbed to a dry, fibrous matrix. | 2014-05-01 |
20140120536 | POLYNUCLEOTIDES FOR THE AMPLIFICATION AND DETECTION OF CHLAMYDIA TRACHOMATIS AND NEISSERIA GONORRHOEAE - Polynucleotides useful for detecting | 2014-05-01 |
20140120537 | Collection and Concentration System for Biologic Substance of Interest and Use Thereof - A system and method thereof for collecting and concentrating a biologic substance of interest is provided. The biologic of interest obtained from a biologic sample present at an initial low concentration (or low number counts) can be captured and released through a collection device of the system to an intermediate second concentration, and further recovered through a concentration device of the system to a third concentration, thereby facilitating subsequent detection, characterization, enumeration, immunostaining, inspection, imaging, culturing, molecular analysis, and/or other assays. | 2014-05-01 |
20140120538 | COELENTERAZINE ANALOGUES AND COELENTERAMIDE ANALOGUES - Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide. | 2014-05-01 |
20140120539 | Systems and Methods for Bead-Free Detection of Nucleotides - Methods and systems of quantifying a target material in solution include detection of a size change of a hybridized nucleic acid complex, without the use of nanobeads. In particular, the examples include providing a plurality of nucleic acid fragments and a species-specific oligonucleotide tags, measuring the size of the nucleic acid fragments and/or oligonucleotides to predetermine a standard distribution of the solution(s), introducing the oligonucleotides in a solution containing nucleic acid target materials and/or non-target materials, and hybridizing the oligonucleotides with the species-specific target material if present in the solution. The size of the nucleic acid complexes in solution are then measured after hybridization, and the presence or non-presence of the species-specific target material is detected and/or quantified by comparing the measured size of the nucleic acid complexes after hybridization to the standard distribution. | 2014-05-01 |
20140120540 | METHODS OF DETECTING GENE FUSIONS - Disclosed herein are methods of detecting presence of a gene fusion in a sample from a subject. In some embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize a fusion probe that spans the point of fusion between two nucleic acids or genes, and detecting the fusion probe after nuclease treatment. In other embodiments, the methods of detecting presence of a fusion gene in a sample from a subject utilize two or more probes that flank the point of fusion between two nucleic acids or genes, and detecting these probes after nuclease treatment. In additional embodiments, the methods can include determining the percentage of gene fusion in the sample relative to the first nucleic acid or the second nucleic acid. | 2014-05-01 |
20140120541 | METHOD FOR DIRECT AMPLIFICATION FROM CRUDE NUCLEIC ACID SAMPLES - The present teachings relate to improved methods, kits, and reaction mixtures for amplifying nucleic acids. In some embodiments a novel direct buffer formulation is provided which allows for the direct amplification of the nucleic acids in a crude sample with minimal sample purification. | 2014-05-01 |
20140120542 | Somatic Cells with Innate Potential for Pluripotency - Aspects of the present invention are drawn to compositions of somatic cells with innate potential for pluripotency (SCIPP). SCIPP have the capacity to differentiate into functional derivatives of each of the major germ layers (i.e., ectodermal, endodermal and mesodermal). Also provided are methods and kits for identifying and isolating the somatic cells from a subject as well as for employing SCIPP for research or therapeutic purposes. | 2014-05-01 |
20140120543 | EXPRESSION OF ISOFORM 202 OF ERCC1 FOR PREDICTING RESPONSE TO CANCER CHEMOTHERAPY - An in vitro method for detecting the susceptibility of a tumor cell to a chemotherapy is disclosed. The method includes the step of measuring the expression level of the isoform 202 of the ERCC1 protein. | 2014-05-01 |
20140120544 | METHOD AND MATERIALS FOR ISOLATION OF NUCLEIC ACID MATERIALS - A method for nucleic acid isolation comprising: receiving a binding moiety solution within a process chamber; mixing the binding moiety solution with a biological sample, within the process chamber, in order to produce a moiety-sample mixture; incubating the moiety-sample mixture during a time window, thereby producing a solution comprising a set of moiety-bound nucleic acid particles and a waste volume; separating the set of moiety-bound nucleic acid particles from the waste volume; washing the set of moiety-bound nucleic acid particles; and releasing a nucleic acid sample from the set of moiety-bound nucleic acid particles. The method preferably utilizes a binding moiety comprising at least one of poly(allylamine) and polypropylenimine tetramine dendrimer, both of which reversibly bind and unbind to nucleic acids based upon environmental pH. | 2014-05-01 |
20140120545 | METHODS OF USING miRNA FROM BODILY FLUIDS FOR EARLY DETECTION AND MONITORING OF MILD COGNITIVE IMPAIRMENT (MCI) AND ALZHEIMER'S DISEASE (AD) - Described are methods for early diagnosis and progression monitoring of Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD) by quantifying neurite and/or synapse miRNAs in bodily fluids. | 2014-05-01 |
20140120546 | METHOD OF PROCESSING A SAMPLE FOR ANALYSIS - A method of processing a sample for analysis is disclosed. The method includes providing a sample, a container, and a cap comprising an elastically-deformable slit. The method further includes affixing the cap to the container, depositing the sample into the container, and exposing the sample to a temperature about 85-100° C. to form a cell lysate. The method further can comprise detecting an analyte in the sample. A kit comprising at least one of the containers, at least one of the caps, and a reagent that facilitates cell lysis is also provided. Optionally, the kit can further comprise a detection reagent. | 2014-05-01 |
20140120547 | ALKYL AMINES IMPROVE DETECTION OF COMPONENTS OF FORMALDEHYDE-FIXED BIOLOGICAL SAMPLES - Alkyl amines act to release formaldehyde cross-linking that occurs in biological samples. Thus, contacting alkyl amines to formaldehyde fixed samples is a useful way to render biological components of the samples, including nucleic acids or proteins, more accessible to detection and characterization. | 2014-05-01 |
20140120548 | SYNTHETIC OPLOPHORUS LUCIFERASES WITH ENHANCED LIGHT OUTPUT - A polynucleotide encoding a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type | 2014-05-01 |
20140120549 | HIGH SENSITIVITY QUANTITATION OF PEPTIDES BY MASS SPECTROMETRY - The instant invention provides an economical flow-through method for determining amount of target proteins in a sample. An antibody preparation (whether polyclonal or monoclonal, or any equivalent specific binding agent) is used to capture and thus enrich a specific monitor peptide (a specific peptide fragment of a protein to be quantitated in a proteolytic digest of a complex protein sample) and an internal standard peptide (the same chemical structure but including stable isotope labels). Upon elution into a suitable mass spectrometer, the natural (sample derived) and internal standard (isotope labeled) peptides are quantitated, and their measured abundance ratio used to calculate the abundance of the monitor peptide, and its parent protein, in the initial sample. | 2014-05-01 |