49th week of 2020 patent applcation highlights part 28 |
Patent application number | Title | Published |
20200377791 | QUANTUM DOT, PREPARATION METHOD THEREFOR AND USE THEREOF - A quantum dot and its preparation method and application. The method includes the steps of forming a compound quantum dot core first, then adding a precursor of a metal element M | 2020-12-03 |
20200377792 | ETCHING COMPOSITIONS - The present disclosure is directed to etching compositions that are useful for, e.g., selectively removing tantalum nitride (TaN) from a semiconductor substrate. | 2020-12-03 |
20200377793 | COMPOSITION FOR ETCHING, METHOD FOR ETCHING INSULATOR AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE, AND NOVEL COMPOUNDS - An etching composition contains phosphoric acid, phosphoric anhydride, a compound represented by the following Formula 1, and a silane compound comprising at least one silicon (Si) atom, excluding the compound represented by Formula 1: | 2020-12-03 |
20200377794 | SILANE COMPOUND - An etchant composition includes a silane compound represented by the following Chemical Formula 1: | 2020-12-03 |
20200377795 | LIQUID CRYSTAL DISPLAY DEVICE AND METHOD FOR PRODUCING LIQUID CRYSTAL DISPLAY DEVICE - The present invention provides a liquid crystal display device whose liquid crystal layer is prevented from undergoing a phase transition while the device is on. A liquid crystal display device according to the present invention includes a first substrate having a thin-film transistor element, a heatsink film overlapping the thin-film transistor element, a first alignment film, a liquid crystal layer, and a second substrate in order. The heatsink film contains a liquid-crystalline polymer as the polymerized form of a liquid-crystalline monomer and also contains inorganic fine particles, and the liquid-crystalline polymer is aligned in-plane with respect to the heatsink film. Preferably, the liquid-crystalline monomer is represented by a specified chemical formula. | 2020-12-03 |
20200377796 | Negative Dielectric Anisotropic Liquid Crystal Compound, Process For Preparing The Same, And Use Thereof - Disclosed is a negative dielectric anisotropic liquid crystal compound represented by Formula (I): | 2020-12-03 |
20200377797 | HYDROGEN-ENHANCED DELAYED COKING PROCESS - A method is described for treating a hydrocarbon oil feedstream to a delayed coking unit to maximize the ratio of the yield of liquids-to-gases, and to minimize the formation of coke which includes:
| 2020-12-03 |
20200377798 | PROCESS FOR CONVERSION OF FUEL GRADE COKE TO ANODE GRADE COKE - The present invention relates to a conversion of fuel grade coke produced through thermal cracking of heavy petroleum residue to anode grade coke. More specifically, the present invention provides a process which employs high sulfur fuel grade coke as the feedstock to produce low sulfur coke which can be used to manufacture electrodes for use in aluminium industry. Further, the invention also relates to a system for removal of metal content from coke and conversion of fuel grade coke to anode grade coke. | 2020-12-03 |
20200377799 | Catalyst and process for the production of diesel fuel from national gas, natural gas liquids, or other gaseous feedstocks - A unique process and catalyst is described that operates efficiently for the direct production of a high cetane diesel type fuel or diesel type blending stock from stochiometric mixtures of hydrogen and carbon monoxide. This invention allows for, but is not limited to, the economical and efficient production high quality diesel type fuels from small or distributed fuel production plants that have an annual production capacity of less than 10,000 barrels of product per day, by eliminating traditional wax upgrading processes. This catalytic process is ideal for distributed diesel fuel production plants such as gas to liquids production and other applications that require optimized economics based on supporting distributed feedstock resources. | 2020-12-03 |
20200377800 | Removable Bend Cap in Tubing for Industrial Process Equipment - An apparatus for heating a fluid is provided, the apparatus comprising a chamber and one or more tubes for conveying the fluid through the chamber, wherein at least one of the tubes has a bend and the bend comprises a removable bend cap including at least one microwave emitter. In another aspect, there is provided an apparatus for removably attaching a bend in tubing for conveying a fluid through the enclosure, the bend having a removable bend cap, and the apparatus comprising a sleeve extending through an opening in the enclosure, wherein the sleeve is adapted to receive the removable bend cap. In yet another aspect, there is provided an apparatus having an enclosure and tubing within the enclosure, the tubing being to convey fluid through the enclosure. At least one of the tubes has a bend, and the bend comprises a removable bend cap which comprises a cleaning device. | 2020-12-03 |
20200377801 | TUBE FOR A STEAM CRACKING FURNACE HAVING A SEGMENT WITH AN ELLIPTICAL OR LOBED CROSS SECTION - A tube for a steam cracking furnace comprising: at least one downstream tubular segment of circular section having a main diameter; at least one twisted tubular segment having a length less than a quarter of the length of the tube, and comprising: a central part with an elliptical or lobed section, having a helical pitch between one times and ten times the main diameter, and an aspect ratio of the elliptical or lobed section between 0.5 and 0.8; an upstream transition part establishing a geometric transition between the central part and a tubular segment of circular section; a downstream transition part establishing a geometric transition between the central part and the downstream tubular segment, with a fluid being intended to flow from the upstream transition part to the downstream transition part. | 2020-12-03 |
20200377802 | FLASH CHEMICAL IONIZING PYROLYSIS OF HYDROCARBONS - Flash chemical ionizing pyrolysis (FCIP) process. The FCIP includes mixing an iron source material, an alkali or alkaline earth metal chloride source material, an aqueous phase, and an oil component to form a feed emulsion; introducing the feed emulsion into an FCIP reactor at a temperature greater than about 400° C. up to about 600° C., a pressure from 10 to 50 psia and a residence time of 0.1 to 10 seconds, to form an FCIP effluent; and condensing a liquid ionizing pyrolyzate (LIP) from the effluent. The feed emulsion can be free of added solids other than the iron source material, the alkali or alkaline earth metal chloride source material, and any sediment in the oil component. | 2020-12-03 |
20200377803 | HYDRODEOXYGENATION OF LIGNIN TO HYDROCARBONS USING BIMETALLIC CATALYSTS - Bimetallic catalysts for the hydrodeoxygenation (HDO) conversion of lignin into useful hydrocarbons are provided. The catalysts are bifunctional bimetallic ruthenium catalysts Ru-M/X | 2020-12-03 |
20200377804 | METHOD OF DOSING A SYSTEM WITH HCL THEN EVACUATING AND PURGING - A method of dosing a system with HCL is provided. The method includes at least two parallel trains. The method utilizes a first operating mode, wherein at least one primary train is actively providing HCL to an end user, and at least one secondary train is either inactive or also providing HCL to the end user. The method utilizes a second operating mode, wherein the least one primary train is evacuating the contents of the train to a disposal system, and the at least one secondary train is providing HCL to the end user. And the system utilizes a third operating mode, wherein the at least one primary train is purging the train, and the at least one secondary train is providing HCL to the end user. The first operating mode, the second operating mode, and the third operating mode are controlled by an electronic monitoring and control system. | 2020-12-03 |
20200377805 | METHODS AND SYSTEMS FOR REMOVING GAS CONTAMINANTS FROM FLOWING SOLIDS - A method for removing gas contaminants from flowing solids in a fluid catalytic cracking (FCC) process can include: catalytically cracking a hydrocarbon feedstock in the presence of a catalyst in a riser of a FCC unit to produce a hydrocarbon product; separating the hydrocarbon product from a spent catalyst to produce a hydrocarbon product stream; regenerating the spent catalyst in a regeneration gas comprising oxygen to produce a mixture comprising a regenerated catalyst and a gas contaminant at a first concentration; introducing a stripping gas and the mixture into a regenerated catalyst stripper to produce a regenerated catalyst stream comprising the regenerated catalyst, the stripping gas, and a gas contaminant at a second concentration that is reduced by 50% or greater as compared to the first concentration; and introducing the regenerated catalyst stream to the riser. | 2020-12-03 |
20200377806 | SYSTEMS AND PROCESSES FOR SUPPRESSING HEAVY POLYNUCLEAR AROMATIC DEPOSITION IN A HYDROCRACKING PROCESS - The disclosure describes refinery processes and process units for suppressing the precipitation and deposition of heavy polynuclear aromatic (HPNA) compounds in a process unit of a refinery, by combining the effluent from a hydrocracking unit with an aromatic solvent stream. Certain costly HPNA treatment processes can be eliminated, downtime can be reduced, and overall distillate yield can be increased by suppressing HPNA precipitation. The aromatic bottoms—which are suitable solvents for this purpose—of an aromatic recovery complex can be used in certain embodiments to dissolve HPNAs and suppress HPNA precipitation. | 2020-12-03 |
20200377807 | Process For The Production Of Petrochemical Feedstock And High Octane Gasoline From Middle Distillates - The present invention provides a process for upgrading LCO to (i) high octane gasoline and high aromatic feedstock for aromatic complex, (ii) Utilization of FCC for cracking unconverted diesel range stream from hydrocracker to high octane gasoline. This invention discloses the process to improve the quality (e.g., RON, Sulfur) of gasoline by utilizing FCC and hydrocracking processes. | 2020-12-03 |
20200377808 | Hydrocarbon Pyrolysis Processes - A hydrocarbon conversion process comprises pyrolysing at a temperature ≥700° C. a feedstock comprising hydrocarbon to produce a pyrolysis effluent comprising at least one C | 2020-12-03 |
20200377809 | ADDITIVES FOR ENHANCEMENT OF OIL FLOW - Use of pyrolysis oil (commonly referred to as bio-oil, bio-crude or tire oil) in combination with naphtha or liquified petroleum gas (LPG) can be utilized to reduce viscosity, increase API gravity and/or liquify paraffin and/or asphaltene in heavy crude oil at a reduced, overall percentage of naphtha. | 2020-12-03 |
20200377810 | METHOD AND USE TO PREVENT DEPOSITS IN ENGINE - A gasoline fuel composition comprising as an additive an ester compound which is the reaction product of an optionally substituted polycarboxylic acid or an anhydride thereof and an alcohol or formula H—(OR) | 2020-12-03 |
20200377811 | METHOD AND USE - A diesel fuel composition comprising as an additive an ester compound which is the reaction product of an optionally substituted polycarboxylic acid or an anhydride thereof and a polyhydric alcohol of formula H—(OR) | 2020-12-03 |
20200377812 | FUEL OIL / PARTICULATE MATERIAL SLURRY COMPOSITIONS AND PROCESSES - This document relates to a fuel oil composition comprising: (i) a solid hydrocarbonaceous and/or solid carbonaceous material, wherein the material is in particulate form, and wherein at least about 90% by volume (% v) of the particles are no greater than about 20 microns in diameter; and (ii) a liquid fuel oil; wherein the solid hydrocarbonaceous and/or solid carbonaceous material is present in an amount of at most about 30 by mass (% m) based on the total mass of the fuel oil composition. The invention further relates a process for the preparation of this fuel oil composition, a method of changing a grade of a liquid fuel oil, and a method for adjusting the flash point of a liquid fuel oil. | 2020-12-03 |
20200377813 | METHOD FOR INCREASING AMOUNT OF HYDROCARBON OIL, METHOD FOR PRODUCING HYDROCARBON OIL, METHOD FOR ESTIMATING INCREASE AMOUNT OF HYDROCARBON OIL, PROGRAM FOR EXECUTING METHOD FOR ESTIMATING INCREASE AMOUNT OF HYDROCARBON OIL, AND DEVICE FOR ESTIMATING INCREASE AMOUNT OF HYDROCARBON OIL - One embodiment of the present invention provides a method for increasing the amount of a hydrocarbon oil, said method being characterized by comprising mixing air-bubbled water with methanol in the presence of a catalyst to produce a mixed solution, mixing the mixed solution with a hydrocarbon oil to produce an emulsion, and bringing the emulsion into contact with a gas or an aqueous solution each containing carbon dioxide, wherein the amount of the hydrocarbon oil is increased in accordance with the reactions represented by (formula 1) and (formula 2): (1) C | 2020-12-03 |
20200377814 | METHOD FOR ODORIZING NATURAL GAS - The present disclosure provides a system and method for odorizing natural gas flowing through a distribution pipeline. The system includes a bypass line adjacent to a distribution pipeline, wherein bypass gas flows through the bypass line and an odorant tank connected to the bypass line, and into the distribution pipeline; a high-flow control valve and a low-flow control valve in the bypass line, wherein bypass gas flows through the odorant tank into the distribution pipeline when the high-flow control valve or the low-flow control valve is open; and a programmable logic controller connected to the high-flow and low flow control valve; wherein the programmable logic controller opens the high-flow or low-flow control valve for a predetermined dwell time proportional to an amount of bypass gas needed to odorize gas in the distribution pipeline each time that a preselected quantity of gas flows through the distribution pipeline. | 2020-12-03 |
20200377815 | POLYISOBUTYLENE-SUBSTITUTED PHENOL, DERIVATIVES THEREOF, AND LUBRICATING COMPOSITIONS CONTAINING THE POLYISOBUTYLENE-SUBSTITUTED PHENOL AND ITS DERIVATIVES - A polyisobutylene-substituted hydroxyaromatic compound and derivatives thereof which are suitable for use as additives in lubricating compositions. The polyisobutylene-substituted hydroxyaromatic compound may include the reaction product of a hydroxyaromatic compound with a polyisobutylene having a number average molecular weight of 150 to 800. | 2020-12-03 |
20200377816 | COFFEE LUBRICANT HAVING NANOPARTICLES - A coffee lubricant having nanoparticles is provided. It consists of 36 to 40 wt % of glycerin, 1 to 7 wt % of gum arabic, 0.3 to 1.3 wt % of nanoparticles, and remaining part of coffee biofuel. In which, the nanoparticles are CuO. The coffee biofuel is extracted from coffee dregs and has a viscosity of 60 to 70 cSt at a temperature of 40 degrees Celsius. It can reduce the friction coefficient and operating temperature. In addition, it can replace the mineral oil. | 2020-12-03 |
20200377817 | Lubricating Compositions - A lubricating composition suited for use in lubricating a driveline device includes an oil of lubricating viscosity and a compound comprising a polyolefin-substituted bridged hydroxyaromatic compound or metal salt thereof, wherein the polyolefin is derived from a isobutylene having a number average molecular weight of 150 to 800. | 2020-12-03 |
20200377818 | SOLVENT FREE PROCESS FOR EXTRACTION OF CHOLESTEROL FROM MILK FAT - The present invention discloses solvent free process for extracting cholesterol free of impurities from milk fat. The so isolated cholesterol is useful for the further preparation of vitamin D3. The present invention further provides pharmaceutical grade cholesterol from milk fat of high purity. | 2020-12-03 |
20200377819 | Novel Stripping Process for Reduction of GEs and 3-MCPD Esters from Edible Oils - Methods are described for removing contaminants, including glycidyl fatty acid esters, 3-monochloropropane diol and toxins from edible oils by using short path stripping at reduced temperatures and pressures. | 2020-12-03 |
20200377820 | EFFICIENT BIOMASS CARBON-BASED SOLID ACID ESTERIFICATION CATALYST FOR PRODUCING BIODIESEL - A method for producing biodiesel using a sulfonated, carbonaceous catalyst produced from rice husk, | 2020-12-03 |
20200377821 | Method, System and Product of Ultrasonic Cleaning of Drill Cuttings - A method, system and cleaning solutions for the ultrasonic cleaning of drill cuttings and the resulting cleaned drill solids is described. The drill cuttings are characterized by their liquid/solid composition, texture of solids and size of particulates. A cleaning solution formula having surfactant(s) and viscosity agent(s) is selected based on the characterization of drill cuttings. Drill cuttings are contacted with the selected cleaning solution and subjected to ultrasonic vibrations simultaneously for a period of treatment and vibration time. Contaminants from drill cuttings are removed to beneficial use standards and the resulting cleaned drill solids may be reused at the well site. The cleaning may occur at a well site in conjunction with drilling activity and the cleaning solution may be changed to adapt to changes in the drill mud and/or cuttings characteristics. | 2020-12-03 |
20200377822 | Cleaning Formulations for Chemically Sensitive Individuals: Compositions and Methods - The present disclosure relates to cleaning compositions in general, and cleaning compositions that are well suited for use by individuals, who experience adverse health effects that may occur upon exposure to certain chemicals. This condition, characterized as multiple chemical sensitivities (MCS), makes it virtually impossible for certain individuals to use commercially available cleaning products without inducing immunological responses. The disclosure presents and describes protocols for the formulation and evaluation of a variety of cleaning products using a combination of | 2020-12-03 |
20200377823 | COMPOSITIONS INCLUDING KETO-ESTER COMPOUNDS AND METHODS OF USING THE SAME - Compositions that include at least one low molecular weight to oxygen containing solvent and one or more compounds of formula (I) wherein R is a C | 2020-12-03 |
20200377824 | SHAPED DETERGENT PRODUCT COMPRISING AMINOPOLYCARBOXYLATE - A shaped detergent product comprising 10 to 100 wt. % of a first solid phase and 0 to 90 wt. % of one or more other phases, said first solid phase comprising: a) non-crystalline chiral aminopolycarboxylate; b) non-crystalline organic acid other than component a); c) at most 30 wt. % water; d) at most 50 wt. % of non-crystalline water-soluble component other than component a) or component b); e) at most 20 wt. % of homogeneously dispersed crystalline material; wherein the combination of the components a), b) and c) is present in the first solid phase in a concentration of at least 35 wt. % of the total weight of said solid phase; and wherein components a), b) and c) are present in the solid phase in a ratio of from 25 to 88 parts by weight of free acid equivalent of component a): from 10 to 60 parts by weight of free acid equivalent of component b) : from 2 to 30 parts by weight of component c); and wherein the shaped detergent product comprises at least 0.5 wt. % surfactant. | 2020-12-03 |
20200377825 | PYRITHIONE PRESERVATIVE SYSTEM IN FLOOR CLEANING PRODUCTS - Solid rinse aid compositions and methods of making and using the same are disclosed. Solid rinse aid compositions include in a single concentrate composition a pyrithione preservative system to replace conventional preservatives in the isothiazolinone family, such as chloromethylisothiazolinone. Beneficially, the pyrithione preservative systems eliminate the need for any personal protective equipment to handle the solid rinse aid compositions. Methods of making and use using the rinse aids are also disclosed. | 2020-12-03 |
20200377826 | LIQUID HAND DISHWASHING DETERGENT COMPOSITION - The need for a liquid hand-dishwashing composition which provides further improved sudsing volume and longevity when washing dishware, especially at elevated temperatures, using diluted liquid hand dishwashing compositions, and especially in the presence of greasy soil and particulate soil, while avoiding unsightly residues on dishware, is met by combining a sudsing surfactant system with an EO-PO-EO triblock copolymer and an ethoxylated polyethyleneimine which does not comprise any further alkoxylations. | 2020-12-03 |
20200377827 | STABLE ANHYDROUS LAUNDRY DETERGENT CONCENTRATE AND METHOD OF MAKING SAME - The invention relates to stable, anhydrous laundry detergent concentrated formulation in solid forms. | 2020-12-03 |
20200377828 | COMPOSITIONS, METHODS AND SYSTEMS FOR REMOVAL OF STARCH - The present invention is directed to compositions, methods and systems for the removal of starch. The methods include: providing cleaning solution and rinsing fluid along supply line(s); connecting the supply line(s) to one or more cleaning applicators positioned to apply the cleaning solution or the rinsing fluid to one or more surfaces of a starch applicator system; and providing a controller which is able to control application of the cleaning solution and the rinsing fluid through the one or more cleaning applicators. The systems include the components described in relation to the methods. The compositions include about 5 to 15% w/w alpha amylase to break down the starch into water-soluble units; and non-ionic surfactant(s) and/or solvent(s) to react at the interface of the starch and surface it is attached to as well as liquify the resins. | 2020-12-03 |
20200377829 | CLEANING FORMULATION FOR REMOVING RESIDUES ON SURFACES - This disclosure relates to a cleaning composition that contains 1) at least one redox agent; 2) at least one first chelating agent, the first chelating agent being a polyaminopolycarboxylic acid; 3) at least one metal corrosion inhibitor, the metal corrosion inhibitor being a substituted or unsubstituted benzotriazole; 4) at least one pH adjusting agent, the pH adjusting agent being a base free of a metal ion; and 5) water. This disclosure also relates to a method of using the above composition for cleaning a semiconductor substrate. | 2020-12-03 |
20200377830 | SHAPED DETERGENT PRODUCT COMPOSITION COMPRISING AMINOPOLYCARBOXYLATE - The invention relates to a shaped detergent product comprising 10-100 wt. % of a solid amorphous phase and 0-90 wt. % of one or more other solid phases, said solid amorphous phase comprising:
| 2020-12-03 |
20200377831 | SYSTEMS AND METHODS FOR PROCESSING NON-FERMENTED LIQUIDS - Embodiments described herein generally relate to systems and methods for processing non-fermented liquids. In some embodiments, non-fermented liquids may be processed into fermentable liquids in relatively short time (e.g., less than or equal to 30 minutes). In certain embodiments, the non-fermented liquids may be processed in relatively small batches (e.g., having a volume of less than or equal to 2 liters). The systems and methods described herein may be useful for producing fermented (e.g., alcoholic) beverages by a consumer. Advantageously, the systems and methods may be for use by a consumer where, upon introduction of a non-fermented liquid into the system, a fermented beverage is produced (e.g., in relatively small batches and/or in relative short times) as compared to traditional fermentation systems and methods (e.g., requiring relatively long fermentation times and/or relatively large batches). In certain embodiments, the systems and methods produce fermented beverages in a substantially continuous manner (e.g., as compared to traditional fermentation systems which utilize batch and/or semi-batch processes). Such systems may be useful for, for example, on-demand brewing of alcoholic beverages. | 2020-12-03 |
20200377832 | SYSTEM AND METHOD FOR PURIFICATION OF DRINKING WATER, ETHANOL AND ALCOHOL BEVERAGES OF IMPURITIES - A system and method of the purification of drinking water, ethanol and alcohol beverages is based on the action of hydrodynamic cavitation processing of microbiological and chemical contaminants, micro particles and colloidal particles. The fluid flow moves at a high rate through a multi-stage cavitation device and filtration module to generate hydrodynamic cavitation features in the fluid flow. The cavitation features generate changes in the velocity, pressure, temperature, chemical composition and physical properties of the liquid. The cavitation features also prevent the deposition of contaminants upon and remove contaminants from the surface of the filter module, reduce the load on the filter elements and increase the life of the filter module. | 2020-12-03 |
20200377833 | CELL PICKING DEVICE - A cell picking device includes a sucker having a pipette tip attached to a tip portion of the sucker and is used to suck the cell from a tip of the pipette tip, a driver configured to cause the sucker to perform a suction operation and move the sucker in a horizontal-plane direction and an axial direction of the pipette tip with the sucker inclined with respect to a vertical direction. A controller moves the sucker such that the tip of the pipette tip moves in a horizontal direction while being in contact with a bottom surface of the container installed on the sample mounting stage in a predetermined position on the sample mounting stage to desorb a cell arranged in the predetermined position from the bottom surface of the container, and suck the cell desorbed from the bottom surface of the container from the tip of the pipette tip. | 2020-12-03 |
20200377834 | REACTOR FOR MANUFACTURING BIOGAS FROM ORGANIC RAW MATERIAL USING ANAEROBIC DIGESTION - The reactor is for manufacturing biogas from organic raw material using anaerobic digestion. The reactor includes a tubular reaction chamber with a substantially rectangular cross-section composed of a bottom, walls and a ceiling for processing raw material into end products. Agitation and transfer equipment are arranged in the reaction chamber and an external support frame structure is arranged on the outer surface included in the reaction chamber for stiffening and supporting the reaction chamber externally against forces generated by the raw material. | 2020-12-03 |
20200377835 | FUNNEL-GUIDED MICROTISSUE STACKING AND MANIPULATION - The invention provides a device and a method for the assembly of an aggregation of adherent cells, particularly a three-dimensional assembly of adherent cells. | 2020-12-03 |
20200377836 | MEMBRANE AND METHOD FOR CULTURE AND DIFFERENTIATION OF CELLS - Provided is a membrane for cell culture and differentiation. The membrane has a base portion and an array of protrusions consisting of a plurality of protrusions. The protrusions are substantially evenly distributed on the base portion. The plurality of protrusions has dimensions on the order of micrometers. In particular, the membrane consists of particles of different particle sizes of two or more kinds. One kind of particles have an average particle size of 1 μm to 50 μm. Two or more kinds of particles of different particle sizes include nanoscale particles, 10-900 nm. One kind of particles are selected from the group consisting of inorganic compound microspheres. The other kind of particles of the two or more kinds of particles of different particle sizes are selected from the group consisting of organic polymer nanospheres. Also provided is a method for maintaining, culturing and/or differentiating cells using such membrane. | 2020-12-03 |
20200377837 | BIOCOMPATIBLE THREE-DIMENSIONAL NETWORK AND USE THEREOF AS A CELL SUPPORT - A subject of the invention is an infusible three-dimensional network of crosslinked polymer fibres, suitable as a cell support, and in particular characterized in that the diameter of said fibres is comprised between 0.1 and 1.5 μm, the size of the interstices between said fibres is comprised between 0.1 and 50 μm | 2020-12-03 |
20200377838 | A Microfluidic Device for Culturing Cells Comprising A Biowall, A Bead Bed and A Biointerface and Methods of Modelling Said Biointerface Thereof - A technique for producing an artificial biointerface involves providing a patterned microfluidic chip having: a chamber divided by a fluid-permeable fencing into a central region and two flanking channels; and at least 3 fluid paths, each of the paths extending across one of the central region and the two flanking channels. A porous packing of rigid beads is placed within the central region to define a bead bed, the beads being of a size to be retained by the fencing. A biowall can be grown on at least one segment of the fencing separating the central region from one flanking channel, the biowall formed at least in part by live cells cultured on the beads. Beads may be modified, coated or functionalized to improve cell attachment and growth, and for reporting, or dosing particles or molecules can be conveniently added to the bead bed. | 2020-12-03 |
20200377839 | METHOD OF ACTUATION OF AN ALTERNATING TANGENTIAL FLOW DIAPHRAGM PUMP - A control unit includes a first connector configured to connect a proportional pressure regulator to a positive pressure supply and a second connector configured to connect the proportional pressure regulator to a negative pressure supply. The control unit further includes at least one sensor configured to detect an amount of air flow (volume per unit of time), positive or negative, within an air flow line connected to an output of the proportional pressure regulator, and a third connector configured to connect the air flow line to an air side of a diaphragm. Additionally, the control unit includes a controller programmed to control at least an opening and closing function of the proportional pressure regulator to attain a desired amount of air flow (volume per unit of time), positive or negative, within the air flow line. | 2020-12-03 |
20200377840 | AUTOMATED BIOREACTOR WITH FOAM COLLECTOR - An apparatus produces a target metabolite in a bioreaction. The apparatus has a reactor vessel that contains a bulk liquor in which the bioreaction is conducted, with a headspace provided above the bulk liquor. In some instances, the target metabolite is favorably partitioned into a foam formed at an interface of the bulk liquor and the headspace. A foam collector is arranged to receive this foam from the bioreactor and break it into a condensed foam liquid, from which the target metabolite may be isolated and purified. In one exemplary application, paenibacillin is produced by fermentation of a medium by | 2020-12-03 |
20200377841 | SYSTEM, METHOD AND APPARATUS FOR DRAINING A BIOREACTOR VESSEL - An apparatus for draining a bioreactor vessel includes a tubular body portion having an interior passageway, and at least one aperture in the tubular body portion providing for fluid communication with the interior passageway, the tubular body portion being configured for positioning at a bottom of a vessel, and a suction tube having a first end configured for fluid coupling with the tubular body portion, and a second end configured for fluid coupling with a port in a sidewall of the vessel. | 2020-12-03 |
20200377842 | CELL IDENTIFICATION SYSTEM AND CELL IDENTIFICATION METHOD - According to one embodiment, a cell identification system includes an imaging device and an identification device. The imaging device includes a well plate, a rotation mechanism, and an imaging part. The well plate is provided with a plurality of wells capable of accommodating cells. The rotation mechanism rotates the cells. The imaging part images the cells. The identification device includes processing circuitry. The processing circuitry controls the rotation mechanism to rotate the cells, controls the imaging part to image the cells each time the cells are rotated by the rotation mechanism, and inputs an image for the cells captured by the imaging part to a learned model so as to identify a cell in a good state from among the cells. | 2020-12-03 |
20200377843 | ULTRA-MICROINJECTION DETECTION AND CONTROL DEVICE BASED ON LENSLESS IMAGING AND METHOD THEREOF - The present invention provides an ultra-microinjection detection and control device based on lensless imaging and a method thereof. A lensless optical liquid level sensor is used to measure a change of a liquid level in an injection needle. A microinjection control unit is used to track the change of the liquid level and correct an injection pressure of the injection pump. Transmitted light generated by a parallel light source passes through a transparent glass tube of the injection needle. Then the transmitted light passes through a light filtering film to reduce the intensity of the parallel light source to a photosensitivity range of a micro linear array image sensor chip. Finally, the transmitted light enters the micro linear array image sensor chip, so that the micro linear array image sensor chip measures the change of the liquid level in the injection needle. | 2020-12-03 |
20200377844 | PREDICTING THE METABOLIC CONDITION OF A CELL CULTURE - A method for predicting the metabolic state of a cell culture of cells of a specific cell type includes providing a metabolic model of a cell of the specific cell type, and performing at each of a plurality of points in time during cultivation of the cell culture, receiving measured concentrations of a plurality of extracellular metabolites and a measured cell density in the culture medium; inputting the received measurements as input parameter values to a trained machine learning program logic—MLP; predicting extracellular fluxes of the extracellular metabolites at a future point in time by the MLP; performing metabolic flux analysis to calculate the intracellular fluxes at the future point in time based on the predicted extracellular fluxes and the stoichiometric equations of the metabolic model. | 2020-12-03 |
20200377845 | NUCLEIC ACID SEPARATING APPARATUS - A nucleic acid separating apparatus includes: a stirring mechanism that stirs and resolving-processes a specimen and a reagent injected into a process tube; a pressurized gas supply mechanism that supplies a pressurized gas to a filter cartridge having a specimen liquid including nucleic acid, the specimen liquid being injected in the filter cartridge after the resolving-process, to separate and collect nucleic acid from the specimen liquid; a dispensing mechanism that injects the specimen, a reagent, or the specimen liquid after the resolving-process into the process tube and the filter cartridge; and a move mechanism that moves the pressurized gas supply mechanism and the dispensing mechanism, wherein the dispensing mechanism includes: a suction and discharge mechanism that is capable of attaching a dispensing chip to the suction and discharge mechanism and detaching the dispensing chip from the suction and discharge mechanism, the suction and discharge mechanism being capable of suctioning and discharging a liquid through the dispensing chip; and a liquid supply mechanism that discharges a liquid from a nozzle. | 2020-12-03 |
20200377846 | YEAST CELL CAPABLE OF SIMULTANEOUSLY FERMENTING HEXOSE AND PENTOSE SUGARS - A method for preparing a yeast capable of simultaneously fermenting a pentose and a hexose sugar, comprising: (a) providing a yeast comprising: one or more heterologous genes encoding an enzyme of a pentose metabolic pathway; disruptions of a gene encoding a ribulose-phosphate 3-epimerase and of a gene encoding a glucose-6-phosphate isomerase; one or more overexpressed endogenous genes encoding an enzyme of the pentose phosphate pathway; and a disruption of one or more genes encoding an NADPH dependent 6-phosphogluconate dehydrogenase, (b) subjecting said yeast to evolutionary engineering on a medium comprising a hexose sugar and at least one pentose sugar, selecting for a yeast with improved growth rate obtain an evolved yeast; (d) restoring, in the evolved yeast, one or more of the disrupted genes, or: (d′) identifying genetic permutations in at least part of the genome of the evolved yeast by genome sequencing; (e) constructing an improved pentose and hexose-fermenting yeast comprising one or more said genetic permutations. Also described is a recombinant yeast comprising one or more heterologous genes of a pentose metabolic pathway, and a gene encoding a variant of a parent polypeptide, the variant comprising an amino acid sequence comprising at least one mutation, when aligned with the amino acid sequence in SEQ ID NO: 6. | 2020-12-03 |
20200377847 | Lysinibacillus Fusiformis With Methylamine Degradability and Application Thereof - The present invention discloses a strain of | 2020-12-03 |
20200377848 | RESOURCE RECOVERY METHOD FOR SIMULTANEOUS PRODUCTION OF MICROBIAL INGREDIENT AND TREATED WATER PRODUCTS - The present invention discloses a method for producing a nutritional microbial solids product while simultaneously producing clean water for multiples uses. The microbial solids product represents a form of single cell protein (SCP) that finds application most typically in formulated animal feeds, but may also be used in food, fertilizer, or soil amendment products. The treated water product can be used directly or polished further for subsequent industrial or agricultural use, including aquaculture and irrigation. The process described utilizes low-value by-products of industrial production for biochemical conversion into SCP. The by-products most suitable to this approach have high organic content that otherwise makes them difficult to dispose of responsibly via traditional methods such as biological wastewater treatment. | 2020-12-03 |
20200377849 | PERFUSION MEDIUM - The invention relates to a method of culturing mammalian cells expressing a heterologous protein in a perfusion cell culture comprising increasing the potassium concentration and decreasing the molar ratio of sodium to potassium to reduce wasteful cell bleed and to increase protein production. The invention further relates to a serum-free perfusion medium comprising a high potassium ion concentration and a low molar ratio of sodium to potassium and to the use of this medium for use in culturing cells in a perfusion culture during production phase or for reducing the cell bleed volume during production phase. | 2020-12-03 |
20200377850 | SEED TRAIN PROCESSES AND USES THEREOF - Provided herein are seed train processes and methods of producing a recombinant protein that include the use of these seed train processes. | 2020-12-03 |
20200377851 | Method for the Cultivation of Glial Cells - The present invention provides a method for the cultivation of glial cells from | 2020-12-03 |
20200377852 | Protein Enriched Microvesicles and Methods of Making and Using the Same - Protein enriched micro-vesicles and methods of making and using the same are provided. Aspects of the methods include maintaining a cell having a membrane-associated protein comprising a first dimerization domain and a target protein having a second dimerization domain under conditions sufficient to produce a micro-vesicle from the cell, wherein the micro-vesicle includes the target protein. Also provided are cells, reagents and kits that find use in making the micro-vesicles, as well as methods of using the micro-vesicles, e.g., in research and therapeutic applications. | 2020-12-03 |
20200377853 | CULTURE CONDITIONS TO PROLONG/ENHANCED ENDODERMAL CELL TYPE FOR CELL TRANSPLANTATION - The present invention includes a method of preparing differentiated endodermal cells comprising growing human pluripotent stem cells (hPSC) under serum free conditions for 3 days on a layer of fibronectin or a gelatinous protein layer in the presence of high activin/TGF-β with a GSK3 inhibitor and a PI3K/mTORC inhibitor in a basal differentiation medium; adding a knock out serum replacement to the media starting on day 4 through day 7; and harvesting the endodermal cells grown therein. | 2020-12-03 |
20200377854 | GENERATION OF NEURAL STEM CELLS AND MOTOR NEURONS - A method of generating a population of cells useful for treating a brain disorder in a subject is disclosed. The method comprises contacting mesenchymal stem cells (MSCs) with at least one exogenous miRNA having a nucleic acid sequence at least 90% identical to a sequence selected from the group consisting of SEQ ID NOs: 15-19 and 27-35, thereby generating a population of cells and/or generating neurotrophic factors that may provide important signals to damaged tissues or locally residing stem cells. MSCs differentiated by miRs may also secrete miRs and deliver them to adjacent cells and therefore provide important signals to neighboring endogenous normal or malignant cells. | 2020-12-03 |
20200377855 | RAPID METHOD FOR THE CULTURE OF TUMOR INFILTRATING LYMPHOCYTES - Disclosed are methods for rapidly expanding tumor infiltrating lymphocytes. | 2020-12-03 |
20200377856 | Genome Edited iPSC-Derived Monocytes Expressing Trophic Factors - Trophic factor expressing monocyte cells derived from gene-edited induced pluripotent stem cells, methods for making and using. | 2020-12-03 |
20200377857 | GENETICALLY ENGINEERED HEMATOPOIETIC STEM CELL AS A PLATFORM FOR SYSTEMIC PROTEIN EXPRESSION - The present invention relates to a genetically modified hematopoietic stem cell comprising, in at least one globin gene comprised in the genome thereof, at least one transgene encoding a therapeutic protein or a therapeutic ribonucleic acid, the said transgene being placed under the control of the endogenous promoter of the said globin gene. | 2020-12-03 |
20200377858 | QUALITY ASSURANCE OF CHONDROCYTES - The present invention relates to methods that are based on expression of integrin alpha10 and integrin alpha11 on chondrocytes, used for determining purity, quality, degree of chondrocytic identity, chondrocytic potency, and/or degree of chondrocytic phenotype of a composition comprising chondrocytes, as well as for isolating and enriching a population of high quality chondrocytes and controlling culturing and expanding of high quality chondrocytes. The present invention relates also to composition comprising chondrocytes. | 2020-12-03 |
20200377859 | UMBILICAL CORD MESENCHYMAL STEM CELLS (MSCS) AND CULTURE METHOD AND APPLICATION THEREOF - An umbilical cord mesenchymal stern cells (MSCs) and culture method and application thereof, which comprises an MSCs culture step comprising the following substeps: primary culture: culturing Wharton's jelly of an umbilical cord in a serum-free medium under a hypoxic condition; subculture: collecting P | 2020-12-03 |
20200377860 | THREE-DIMENSIONAL DIFFERENTIATION OF EPIBLAST SPHEROIDS TO KIDNEY ORGANOIDS MODELS STAGE-SPECIFIC EPITHELIAL PHYSIOLOGY, MORPHOGENESIS, AND DISEASE - Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease. | 2020-12-03 |
20200377861 | METHODS AND APPARATUSES FOR PATIENT-DERIVED MICRO-ORGANOSPHERES - Micro-Organosphers, including Patient-Derived Micro-Organospheres (PMOS s), apparatuses and methods of making them, and apparatuses and methods of using them. Also described herein are methods and systems for screening a patient using these Patient-Derived Micro-Organospheres, including personalized therapies. | 2020-12-03 |
20200377862 | METHOD FOR PREPARING CANCER STEMNESS CELL LINE THROUGH METABOLIC STRESS, AND CANCER CELL PREPARED THROUGH SAME - The present disclosure relates to a cancer cell line having a stem cellularity and a method for producing the same, and more specifically, to inducing cancer cells to cancer stem cells by applying metabolic stress. More specifically, the present disclosures relates to the production and establishment of the cancer stem cell by repeating culturing in a glucose-deficient medium. The main features of the cancer stem cell produced by the method are that, in a glucose-deficient environment, the resistance to apoptosis is exhibited high and the resistance to anticancer drugs is highly exhibited high. | 2020-12-03 |
20200377863 | MODEL SYSTEM OF LIVER FIBROSIS AND METHOD OF MAKING AND USING THE SAME - Provided herein is a model system for liver fibrosis, including a liver extracellular matrix, and a combination of mammalian liver cells (e.g., primary liver cells) on the matrix. In some embodiments, the combination of liver cells includes: (a) liver progenitor cells, (b) Kupffer cells, and (c) hepatic stellate cells. Methods of making the model system and methods of use of the model system for screening active agents are also provided. | 2020-12-03 |
20200377864 | CELL-DERIVED VIRAL VACCINES WITH LOW LEVELS OF RESIDUAL CELL DNA - The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as β-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA. | 2020-12-03 |
20200377865 | INCREASING PRODUCTIVITY OF E. COLI HOST CELLS THAT FUNCTIONALLY EXPRESS P450 ENZYMES - The present invention relates to the production of chemical species in bacterial host cells. Particularly, the present invention provides for the production of chemical species in | 2020-12-03 |
20200377866 | COMPOSITIONS USEFUL IN TREATMENT OF ORNITHINE TRANSCARBAMYLASE (OTC) DEFICIENCY - Viral vectors comprising engineered hOTC DNA and RNA sequences are provided which when delivered to a subject in need thereof are useful for treating hyperammonemia, ornithine transcarbamylase deficiency and symptoms associated therewith. Also provided are methods of using hOTC for treatment of liver fibrosis and/or cirrhosis in OTCD patients by administering hOTC. | 2020-12-03 |
20200377867 | SUCROSE PHOSPHORYLASE - The present invention relates to a sucrose phosphorylase variant comprising or consisting of an amino acid sequence with at least 75% homologous and/or identical to an amino acid sequence of wild type sucrose phosphorylase, preferably wherein the sucrose phosphorylase is characterized by different structural and functional features. The invention also relates to method for preparing aG1P and a co-product, wherein the method comprises reacting a sucrose phosphorylase with a glucoside substrate, wherein the sucrose phosphorylase is a sucrose phosphorylase as defined in the context of the present invention. | 2020-12-03 |
20200377868 | A138T Mutation-Containing Plant EPSPS Mutant, and Encoding Gene and Application Thereof - The invention provides a plant EPSPS mutant (i.e., 5-enolpyruvylshikimate-3-phosphate synthase mutant), which is derived from a plant and is mutated to have glyphosate resistance. Also provided is an encoding gene, which can encode the plant EPSPS mutant. In addition, a vector containing the encoding gene and a cell containing the vector is provided by the invention. Further, a use of the plant EPSPS mutant is provided. | 2020-12-03 |
20200377869 | INHIBITION OF NUCLEIC ACID POLYMERASES BY ENDONUCLEASE V-CLEAVABLE CIRCULAR OLIGONUCLEOTIDE LIGANDS - Provided are methods and compositions for activating oligonucleotide aptamer-deactivated DNA polymerases, comprising cleaving the aptamer by endonuclease V enzymatic activity to reduce or eliminate binding of the oligonucleotide aptamer to the DNA polymerase, thereby activating DNA synthesis activity of the DNA polymerase in a reaction mixture. Mixtures for use in methods of the invention are also provided. The oligonucleotide aptamers of the present invention are circular and comprise one or more deoxyinosine nucleotides providing for aptamer-specific recognition and cleavage of the circular aptamer by the endonuclease V enzymatic activity. Exemplary oligonucleotide aptamers, mixtures and methods employing endonuclease V enzymatic activity are provided. The methods can be practiced using kits comprising a DNA polymerase-binding oligonucleotide aptamer and at least one endonuclease V enzymatic activity having oligonucleotide aptamer-specific recognition to provide for specific cleavage of the aptamer by the endonuclease V enzymatic activity. | 2020-12-03 |
20200377870 | PROCESSES FOR PRODUCING FERMENTATION PRODUCTS - The present invention relates to processes for producing fermentation products from starch-containing material, wherein an alpha-amylase and a thermostable hemicellulase is present and/or added during liquefaction. The invention also relates to compositions suitable for use in processes of the invention. | 2020-12-03 |
20200377871 | Modulating Human Cas9-Specific Host Immune Response - Provided herein are methods and compositions for reducing an undesirable T cell immune response in human patients prior to and/or during gene therapy using CRISPR/Cas9-based genetic modulation. | 2020-12-03 |
20200377872 | Treatment of Autonomic Disorders with Botulinum Toxin - The present invention relates to the treatment of autonomic disorders with a clostridial neurotoxin comprising a H | 2020-12-03 |
20200377873 | VARIANTS OF PORCINE TRYPSIN - The present invention relates to polypeptide variants of porcine trypsin, to nucleic acid molecules encoding these variants, and to host cells comprising such nucleic acid molecules. It also relates to the use of these variants in methods for producing insulin. The invention further relates to the use of these variants as medicaments, as food ingredients, or as feed ingredients and to the use of these variants within a process of manufacturing a food ingredient or a feed ingredient. | 2020-12-03 |
20200377874 | COMPOSITIONS AND METHODS FOR TREATING LUNG INFLAMMATION - Provided are therapies, including combination therapies, for the treatment of lung inflammation, including interstitial lung diseases (ILDs), which include the use of at least one histidyl-tRNA synthetase (HRS) polypeptide or an expressible polynucleotide that encodes the HRS polypeptide, alone or in combination with at least one immunomodulatory agent. | 2020-12-03 |
20200377875 | METHODS OF ADDING POLYMERS TO RIBONUCLEIC ACIDS - Provided are methods of adding a polymer of non-canonical nucleotides to the 3′ end of a ribonucleic acid (RNA). In certain embodiments, the methods comprise combining an RNA, a polynucleotide-3′ nucleotidyl transferase, and non-canonical nucleotides, in a reaction mixture under conditions in which the polynucleotide-3′ nucleotidyl transferase adds a polymer of the non-canonical nucleotides to the 3′ end of the RNA. Such methods may further include analyzing the RNA using a nanopore. According to some embodiments, the methods include identifying the polymer of non-canonical nucleotides added to the 3′ end of the RNA, and determining the junction between the 3′ end of the RNA and the polymer of non-canonical nucleotides to identify the 3′ end of the RNA. Kits that find use, e.g., in practicing the methods of the present disclosure are also provided. | 2020-12-03 |
20200377876 | Desorption of Nucleic Acids - In a method for the desorption of nucleic acids from a sample, in order to simplify the desorption of nucleic acids from the sample, a solid phase is repeatedly rinsed with an elution buffer in a microfluidic system, in order to elute nucleic acids bonded to the solid phase from the solid phase in the microfluidic system. | 2020-12-03 |
20200377877 | PRODUCTION OF UNNATURAL NUCLEOTIDES USING A CRISPR/CAS9 SYSTEM - Disclosed herein are methods, cells, engineered microorganisms, and kits for increased production of a nucleic acid molecule that comprises an unnatural nucleotide. | 2020-12-03 |
20200377878 | MODIFIED T CELLS AND USES THEREOF - The present invention relates to modified T cells with reduced or abolished TCR/CD3 complex expression, and the methods to produce the same. Also included are pharmaceutical compositions comprising the modified T cell for adoptive therapy and treating a condition, such as cancer, infections or autoimmune diseases. | 2020-12-03 |
20200377879 | MODULATING dsRNA EDITING, SENSING, AND METABOLISM TO INCREASE TUMOR IMMUNITY AND IMPROVE THE EFFICACY OF CANCER IMMUNOTHERAPY AND/OR MODULATORS OF INTRATUMORAL INTERFERON - The present invention relates, in part, to methods of treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of an agent that inhibits or promotes the copy number, the expression level, and/or the activity of one or more biomarkers listed in Table 1 or a fragment thereof. Also provided herein are methods of detecting ADAR1 or ISG15 dependency in a high proliferation cell (e.g., a cancer cell). Also provided are methods of detected increased interferon signaling pathway activity in a high proliferation cell (e.g., a cancer cell). Included herein are methods of treating cancer with inhibitors of ADAR1 or ISG15. Methods of screening for such inhibitors are also provided herein. Methods of identifying the likelihood of a cancer to be responsive to an ADAR1 inhibitor are also provided. | 2020-12-03 |
20200377880 | CONCATEMERIC RNA MOLECULES, COMPOSITIONS, AND METHODS AND USES THEREOF - The present invention relates to concatemeric RNA molecules, compositions, particles, and methods of uses thereof. | 2020-12-03 |
20200377881 | Methods of Genome Engineering by Nuclease-Transposase Fusion Proteins - The present disclosure provides methods and compositions of altering a target nucleic acid sequence in a cell. The methods comprise introducing into the cell a guide RNA comprising a portion that is complementary to all or a portion of the target nucleic acid sequence, introducing into the cell a Cas9 transposase fusion protein, and introducing into the cell a donor nucleic acid sequence, wherein the guide RNA and the Cas9 transposase fusion protein co-localize at the target nucleic acid sequence, wherein the Cas9 transposase fusion protein cleaves the target nucleic acid sequence and the donor nucleic acid sequence is inserted into the target nucleic acid sequence in a site specific manner. | 2020-12-03 |
20200377882 | REDUCING BETA-CATENIN EXPRESSION TO POTENTIATE IMMUNOTHERAPY - Provided herein are methods and compositions for treating cancer, including cancer that is not responsive to immunotherapy. In one aspect, the methods of treatment comprise administering to the subject a therapeutically effective amount of a β-catenin inhibitor and a therapeutically effective amount of an immunotherapeutic agent. Another aspect is directed to pharmaceutical compositions comprising a β-catenin inhibitor for use in treating cancer, wherein the composition is administered in combination with an immunotherapeutic agent. Yet another aspect is directed to a method of potentiating the therapeutic effect of immunotherapy against a cancer using a β-catenin inhibitor, such as a β-catenin nucleic acid inhibitor molecule. | 2020-12-03 |
20200377883 | ANTISENSE OLIGONUCLEOTIDES FOR MODULATING THE FUNCTION OF A T CELL - The present invention relates to antisense oligonucleotides for modulating the function of a T cell, including antisense oligonucleotides that hybridise to IFN-γ, granzyme, perforin 1, PD-1, PRDM1, PD-L1, CD40LG, NDFIP1, PDCD1 LG2, REL, BTLA, CD80, CD160, CD244, LAG3, TIGIT, ADORA2A & TIM-3 RNAs. In particular, the present invention relates to antisense oligonucleotides capable of inducing exon skipping of RNA. Also claimed is a method for further modifying the specificity of said T-cell by providing for a T cell receptor gene. | 2020-12-03 |
20200377884 | CRISPR Fluorescent Guide RNA (fgRNA) to Understanding gRNAs Expressed from Pol II Promotors - Provided herein are tools for understanding and engineering dynamics of synthetic genetic circuits which utilize CRISPR components. More particularly, methods, systems, and compositions for directing Cas9 activity using a fluorescent guide RNA (fgR-NA) which fluoresces in the presence of small molecules (e.g., DFHBI-IT) are described and illustrated in the present provisional application. | 2020-12-03 |
20200377885 | COMPOSITIONS AND METHODS FOR THE GENERATION OF NEURONS AND USES THEREOF - Among the various aspects of the present disclosure is the provision of a method of generating a neuron. In some embodiments, the neuron is generated from an adult fibroblast cell comprising miR-9/9* and miR-124 (miR-9/9-124); and one or more transcription factors. In some embodiments, the transcription factors comprise ISL1 and LHX3 or CTIP2, DLX1, DLX2, and MYT1L (CDM). | 2020-12-03 |
20200377886 | EXON SKIPPING OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY - Antisense oligomer conjugates complementary to a selected target site in the human dystrophin gene to induce exon 53 skipping are described. | 2020-12-03 |
20200377887 | COMPOSITIONS AND METHODS OF TREATING HUNTINGTON'S DISEASE - The present invention relates to adeno-associated viral (AAV) particles encoding siRNA molecules and methods for treating Huntington's Disease (HD). | 2020-12-03 |
20200377888 | RUNX1 INHIBITION FOR TREATMENT OF PROLIFERATIVE VITREORETINOPATHY AND CONDITIONS ASSOCIATED WITH EPITHELIAL TO MESENCHYMAL TRANSITION - The present subject matter provides compositions, formulations and methods for preventing or reducing proliferation or migration of retinal cells or epithelial to mesenchymal transition in ocular cells or cells from other tissues. | 2020-12-03 |
20200377889 | TRANSTHYRETIN (TTR) iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING OR PREVENTING TTR-ASSOCIATED DISEASES - The present invention provides iRNA agents, e.g., double stranded iRNA agents, that target the transthyretin (TTR) gene and methods of using such iRNA agents for treating or preventing TTR-associated diseases. | 2020-12-03 |
20200377890 | CTLA-4 APTAMER CONJUGATES - Provided herein are, inter alfa, nucleic acid compounds useful for targeting CTLA-4-expressing cells and modulating cell activity of the CTLA-4-expressing cells. The compositions provided herein may be part of pharamceutcial compositions and may be used for treatment of cancer, inflammatory diseases, infectious diseases or metabolic diseases. | 2020-12-03 |